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11C methionine positron emission tomography

Tumor to normal tissue ratio (T/N ratio) on 11C-methionine (11C-MET) positron emission tomography/computed tomography (PET/CT) is affected by variable factors.


The metabolically active tumour volume observed in (11)C-methionine PET differs from the volume of MRI by showing areas of infiltrative tumour and distinguishing from non-tumour lesions. Differences in (11)C-methionine PET/MRI integration patterns can be assigned to tumour grades according to the WHO classification. This finding may improve tumour delineation and therapy planning for gliomas 1).

11C methionine positron emission tomography parameters are significantly correlated with histological grade and IDH1 mutation status in patients with glioma. Grade, pathological classification, molecular biomarkers, SUVmax and SUVratio were prognostic factors for PFS in a cohort of patients. The trial was registered with (registration: NCT02518061) 2).

Recurrent brain tumors

The visual assessment showed no significant difference from quantitative assessment of MET-PET with a relevant cut-off value for the differentiation of recurrent brain tumors from radiation-induced necrosis 3).


MET-PET is a sensitive technique for diagnosing persistent acromegaly and its coregistration with 3T MRI has demonstrated a better definition of the interface, extension and location of the lesion in the management of active postoperative acromegaly 4).

Arbizu J, Tejada S, Marti-Climent JM, Diez-Valle R, Prieto E, Quincoces G, Vigil C, Idoate MA, Zubieta JL, Peñuelas I, Richter JA. Quantitative volumetric analysis of gliomas with sequential MRI and ¹¹C-methionine PET assessment: patterns of integration in therapy planning. Eur J Nucl Med Mol Imaging. 2012 May;39(5):771-81. doi: 10.1007/s00259-011-2049-9. Epub 2012 Jan 19. PubMed PMID: 22258713.
Lopci E, Riva M, Olivari L, Raneri F, Soffietti R, Piccardo A, Bizzi A, Navarria P, Ascolese AM, Rudà R, Fernandes B, Pessina F, Grimaldi M, Simonelli M, Rossi M, Alfieri T, Zucali PA, Scorsetti M, Bello L, Chiti A. Prognostic value of molecular and imaging biomarkers in patients with supratentorial glioma. Eur J Nucl Med Mol Imaging. 2017 Jan 21. doi: 10.1007/s00259-017-3618-3. [Epub ahead of print] PubMed PMID: 28110346.
Minamimoto R, Saginoya T, Kondo C, Tomura N, Ito K, Matsuo Y, Matsunaga S, Shuto T, Akabane A, Miyata Y, Sakai S, Kubota K. Differentiation of Brain Tumor Recurrence from Post-Radiotherapy Necrosis with 11C-Methionine PET: Visual Assessment versus Quantitative Assessment. PLoS One. 2015 Jul 13;10(7):e0132515. doi: 10.1371/journal.pone.0132515. eCollection 2015. PubMed PMID: 26167681; PubMed Central PMCID: PMC4500444.
Rodriguez-Barcelo S, Gutierrez-Cardo A, Dominguez-Paez M, Medina-Imbroda J, Romero-Moreno L, Arraez-Sanchez M. Clinical Usefulness of Coregistered 11C-Methionine Pet/ 3t Mri at the Follow Up of Acromegaly. World Neurosurg. 2013 Nov 13. pii: S1878-8750(13)01431-9. doi: 10.1016/j.wneu.2013.11.011. [Epub ahead of print] PubMed PMID: 24239736.
11c_methionine_positron_emission_tomography.txt · Last modified: 2017/06/07 13:34 by administrador