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18f-fdopa_pet

18F-FDOPA PET

18F-3,4-dihydroxyphenylalanine (18F-DOPA) is a labeled amino-acid analog used for Positron Emission Tomography (PET) imaging. Its increased uptake in brain tumours is related to the over-expression of the amino-acid transporter LAT1 in tumour cells and their vasculature 1) 2) 3)

Fluorodopa PET scanning is a valid method for assessing the functional state of the nigrostriatal dopaminergic pathway. It is particularly useful for studies requiring repeated measures such as examinations of the course of a disease and the effect of treatment

18F-FDOPA PET has a significant impact on the management of patients with a suspicion of brain tumor recurrence, either glioblastoma or brain metastases, but a low impact when used to evaluate the residual glioblastoma infiltration after a first-line radiochemotherapy or second-line bevacizumab 4).


A pilot study shows that in diffuse Grade II-III gliomas, a high 18F-FDOPA uptake would be predictive of low tumour growth, with a different prognostic significance than IDH mutation. Advances in knowledge: 18F-FDOPA PET in a single session imaging could have prognostic value in initial diagnosis of diffuse Grade II-III gliomas 5).

References

1)
Miyagawa T, Oku T, Uehara H, Desai R, Beattie B, Tjuvajev J, et al. BFacilitated^ amino acid transport is upregulated in brain tumors. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab. 1998;18:500–9.
2)
Papin-Michault C, Bonnetaud C, Dufour M, Almairac F, Coutts M, Patouraux S, et al. Study of LAT1 expression in brain metastases: towards a better understanding of the results of positron emission tomography using amino acid tracers. PLoS One. 2016;11: e0157139.
3)
Youland RS, Kitange GJ, Peterson TE, Pafundi DH, Ramiscal JA, Pokorny JL, et al. The role of LAT1 in (18)F-DOPA uptake in malignant gliomas. J Neuro-Oncol. 2013;111:11–8.
4)
Humbert O, Bourg V, Mondot L, Gal J, Bondiau PY, Fontaine D, Saada-Bouzid E, Paquet M, Chardin D, Almairac F, Vandenbos F, Darcourt J. (18)F-DOPA PET/CT in brain tumors: impact on multidisciplinary brain tumor board decisions. Eur J Nucl Med Mol Imaging. 2019 Jan 5. doi: 10.1007/s00259-018-4240-8. [Epub ahead of print] PubMed PMID: 30612162.
5)
Isal S, Gauchotte G, Rech F, Blonski M, Planel S, Chawki MB, Karcher G, Marie PY, Taillandier L, Verger A. A high (18)F-FDOPA uptake is associated with a slow growth rate in diffuse Grade II-III gliomas. Br J Radiol. 2018 Apr;91(1084):20170803. doi: 10.1259/bjr.20170803. Epub 2018 Jan 12. PubMed PMID: 29271237; PubMed Central PMCID: PMC5965991.
18f-fdopa_pet.txt · Last modified: 2019/01/07 22:42 by administrador