In 1965 Parkinson 1) was the first to realize an anatomical study and to propose a surgical approach to the cavernous sinus (CS). Despite the development of the microsurgical technique in the seventies, it was thought that microneurosurgery was reaching its furthest limits in the approach of lesions in and around the CS. The extremely high risk of damaging nervous structures, as well as causing uncontrollable haemorrhage or postoperative CSF leak seemed to be an unavoidable and insuperable obstacle. Thanks to the anatomical work of Vinko Dolenc and his surgical experiences, a rational surgical approach was eventually developed and the different relations between the lesion and the neurovascular structures were defined. In Dolenc's book preface, Yasargyl states that “there is no doubt that this type of microsurgical anatomical study is a new step in the 100 year history of neurosurgery” 2).