Since 2005, state-of-the-art therapy in glioblastoma multiforme consists of maximal safe resection followed by combined radiotherapy and chemotherapy with temozolomide, according to Stupp regimen 1). 2) , particularly in patients that demonstrate MGMT promoter methylation. At recurrence there is no consensus as to the standard of care as no therapeutic options have produced substantial survival benefit 3).
Juha Hernesniemi, published the lateral supraorbital craniotomy 4) it avoids the approach through the sylvian fissure (SF) and irrespective of the SF anatomy approaches the aneurysms immediately subfrontally. The SF is only partially open.
The H index was suggested in 2005 by Jorge E. Hirsch, a physicist at UCSD, as a tool for determining theoretical physicists' relative quality and is sometimes called the Hirsch index or Hirsch number.
WANS is a non-profit public benefit association and is established in October 2005 as an honor society to promote cooperation and camaraderie amongst world leaders of neurosurgery, exchange of scientific knowledge and recognition of major contributors to the specialty.