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absence_seizure

Absence seizure

These generalized seizure involve an interruption to consciousness where the person experiencing the seizure seems to become vacant and unresponsive for a short period of time (usually up to 30 seconds). Slight muscle twitching may occur.

Absence seizures are transient episodes of impaired consciousness accompanied by 3-4Hz spike-wave discharge on electroencephalography (EEG).

Human functional magnetic resonance imaging (fMRI) studies have demonstrated widespread cortical decreases in the blood oxygen-level dependent (BOLD) signal that may play an important role in the pathophysiology of these seizures.

3-4Hz spike-wave discharge in a sulcated animal model does not necessarily produce fMRI decreases, leaving the mechanism for this phenomenon open for further investigation 1).

1)
Youngblood MW, Chen WC, Mishra AM, Enamandram S, Sanganahalli BG, Motelow JE, Bai HX, Frohlich F, Gribizis A, Lighten A, Hyder F, Blumenfeld H. Rhythmic 3-4Hz discharge is insufficient to produce cortical BOLD fMRI decreases in generalized seizures. Neuroimage. 2015 Jan 3. pii: S1053-8119(14)01071-4. doi: 10.1016/j.neuroimage.2014.12.066. [Epub ahead of print] PubMed PMID: 25562830.
absence_seizure.txt · Last modified: 2015/01/08 11:40 (external edit)