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carbamazepine

Carbamazepine (CBZ)

Carbamazepine-associated withdrawal reaction (CAWR) is dependent on the pre-operative dosage and the changing rate of pre- and post-operative CBZ blood concentrations 1).

Female patients with epilepsy and an older age, AED polytherapy, and carbamazepine treatment had a higher risk of low fT4. Thyroid function in these patients should be monitored closely. 2).

1)
Chen MJ, Zhang WJ, Guo ZL, Zhang WH, Chai Y, Li YW. Withdrawal reaction of carbamazepine after neurovascular decompression for trigeminal neuralgia: A preliminary study. J Neurol Sci. 2013 Dec 11. pii: S0022-510X(13)03084-0. doi: 10.1016/j.jns.2013.12.013. [Epub ahead of print] PubMed PMID: 24387898.
2)
Shih FY, Chuang YC, Chuang MJ, Lu YT, Tsai WC, Fu TY, Tsai MH. Effects of antiepileptic drugs on thyroid hormone function in epilepsy patients. Seizure. 2017 Mar 19;48:7-10. doi: 10.1016/j.seizure.2017.03.011. [Epub ahead of print] PubMed PMID: 28364656.
carbamazepine.txt · Last modified: 2017/04/03 08:26 by administrador