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circle_of_willis

Circle of Willis (COW)

The Circle of Willis (also called Willis' Circle, Loop of Willis, cerebral arterial circle, and Willis Polygon) is the main collateral system between the bilateral carotid systems and the vertebrobasilar system.

Named after Sir Thomas Willis who described the arterial circle (circulus arteriosus cerebri).

The circle of Willis encircles the stalk of the pituitary gland and provides important communications between the blood supply of the forebrain and hindbrain (ie, between the internal carotid and vertebrobasilar systems following obliteration of primitive embryonic connections). A complete circle of Willis is present in most individuals, although a well-developed communication between each of its parts is identified in less than half of the population 1).

The circle of Willis links the two main cerebral artery systems, namely the internal carotid artery system and the vertebrobasilar system, and it is also the primary collateral pathway locating in the base of brain. When the blood flow of an unilateral artery declines caused by stenosis, it can be compensated from the contralateral side by the CoW. The collateral capacity of the CoW improves cerebral perfusion in ischemic areas and may diminish the effect of ischemic events 2) 3).

This structure provides important collateral circulation paths to maintain the sufficient blood supply, especially when stenosis or surgical clamping of the cerebral arteries happens. These collaterals consist of cross-flow through the anterior communicating artery toward the ipsilateral sphere of the ICA lesion, posterior to anterior flow through the ipsilateral posterior communicating artery, or both these systems 4) 5) 6) 7).

Composition

Anterior cerebral artery (left and right)

Anterior communicating artery

Internal carotid artery (left and right)

Posterior cerebral artery (left and right)

Posterior communicating artery (left and right)

Because the carotid and vertebrobasilar arteries form a circle, if one of the main arteries is occluded, the distal smaller arteries that it supplies can receive blood from the other arteries (collateral circulation).

The pterional approach to aneurysms of the circle of Willis is one of the most common approaches in vascular neurosurgery 8) 9) 10).

Variations

COW normal variants are encountered in up to 62% of subjects.

The morphological variation of the CoW may affect aneurysm formation resulting from increased wall shear stress 11).

A1 segment hypoplasia is an uncommon fetal variant of the circle of Willis.

Hypoplasia or completely absent blood vessels, which may occur in the anterior circulation or the posterior circulation, may influence the collateral capacity of the CoW and the risk of ischaemic stroke. Therefore, evaluating the collateral capacity of different configurable CoWs in patients is very important 12).

There have been some studies performed on haemodynamics of CoW with different anatomical variations in recent years. Some researchers have treated the cerebral vasculature as 1D structure, however, basing on Poiseuille flow, it cannot capture the effects of the complex arterial geometry, especially the effects of blood vessel junctions 13) 14).

Function

The arrangement of the brain's arteries into the Circle of Willis creates redundancies or collaterals in the cerebral circulation. If one part of the circle becomes blocked or narrowed (stenosed) or one of the arteries supplying the circle is blocked or narrowed, blood flow from the other blood vessels can often preserve the cerebral perfusion well enough to avoid the symptoms of ischemia.

Subclavian steal syndrome

The redundancies that the Circle of Willis introduce can also lead to reduced cerebral perfusion.[5][6] In subclavian steal syndrome, blood is “stolen” from the Circle of Willis to preserve blood flow to the upper limb. Subclavian steal syndrome results from a proximal stenosis (narrowing) of the subclavian artery, an artery supplied by the aorta which is also the same blood vessel that eventually feeds the Circle of Willis via the vertebral artery.

Leukoaraiosis

The presence and the number of COW variants are associated with a higher leukoaraiosis volume in patients with significant internal carotid artery stenosis 15).

MRA

Previous studies were mainly based on the study of autopsies, with limitations in reflecting the relationship between COW's morphology and physiological changes of hemodynamic system. Moreover, the number of samples was limited in previous studies and hence their results were not able to represent the population of COW. With the development of modern technology, some new techniques, such as transcranial Doppler (TCD), DSA, and CTA, allow researchers to access the cerebral module on physiological or pathological status. Different from TCD and CTA, MRA (magnetic resonance angiography) is a noninvasive and no-radioactive damage inspection technique, which can be used to undertake a massive study on healthy people on evaluation of COW variation 16) 17) 18).

MRA could enable reflecting the physiological morphology of COW in a comprehensive manner 19).

Assessment of Circle of Willis (CoW) configuration on MRA may be helpful to understand the appearance of unilateral thalamic stroke independent from stroke etiology. A smaller diameter of the relevant CoW segment might be a risk factor for ipsilateral thalamic stroke in the corresponding thalamic vascular territory 20).


Sphenoid wing meningiomas (SWMs) can encase arteries of the circle of Willis, increasing their susceptibility to intraoperative vascular injury and severe ischemic complications.

References

1)
Krabbe-Hartkamp MJ, van der Grond J, de Leeuw FE, de Groot JC, Algra A, Hillen B, et al. Circle of Willis: morphologic variation on three-dimensional time-of-flight MR angiograms. Radiology. Apr 1998;207(1):103-11.
2)
Bisschops RHC, Klijn CJM, Kappelle LJ. et al. Collateral flow and ischemic brain lesions in patients with unilateral carotid artery occlusion. Neurology. 2003;60(9):1435–1441. doi: 10.1212/01.WNL.0000061616.96745.90.
3)
Sallustio F, Kern R, Günther M. et al. Assessment of intracranial collateral flow by using dynamic arterial spin labeling MRA and transcranial color-coded duplex ultrasound. Stroke. 2008;39(6):1894–1897. doi: 10.1161/STROKEAHA.107.503482.
4)
Kluytmans M, van der Grond J, van Everdingen KJ, Klijn CJM, Kappelle LJ, Viergever Ma. Cerebral Hemodynamics in Relation to Patterns of Collateral Flow. Stroke. 1999;30:1432–1439. doi: 10.1161/01.STR.30.7.1432.
5)
Powers WJ. Cerebral hemodynamics in ischemic cerebrovascular disease. Ann Neurol. 1991;29:231–240. doi: 10.1002/ana.410290302.
6)
Powers WJ, Press GA, Grubb RL, Gado M, Raichle ME. The effect of hemodynamically significant carotid artery disease on the hemodynamic status of the cerebral circulation. Ann Intern Med. 1987;106:27–34. doi: 10.7326/0003-4819-106-1-27.
7)
Schomer DF, Marks MP, Steinberg GK, Johnstone IM, Boothroyd DB, Ross MR, Pelc NJ, Enzmann DR. The anatomy of the posterior communicating artery as a risk factor for ischemic cerebral infarction. N Engl J Med. 1994;330:1565–1570. doi: 10.1056/NEJM199406023302204.
8)
Alaywan M, Sindou M. Fronto-temporal approach with orbito-zygomatic removal: Surgical anatomy. Acta Neurochir (Wien) 1990;104:79–83.
9)
Al-Mefty O. Supraorbital-pterional approach to skull base lesions. Neurosurgery. 1987;21:474–7.
10)
Day AL. Aneurysms of the ophthalmic segment: A clinical and anatomical analysis. J Neurosurg. 1990;72:667–91
11)
Nam SW, Choi S, Cheong Y, Kim YH, Park HK. Evaluation of aneurysm-associated wall shear stress related to morphological variations of circle of Willis using a microfluidic device. J Biomech. 2015 Jan 21;48(2):348-53. doi: 10.1016/j.jbiomech.2014.11.018. Epub 2014 Nov 20. PubMed PMID: 25497378.
12)
Henderson RD, Eliasziw M, Fox AJ. et al. Angiographically defined collateral circulation and risk of stroke in patients with severe carotid artery stenosis. Stroke. 2000;31(1):128–132. doi: 10.1161/01.STR.31.1.128.
13)
Moorhead KT, Doran CV, Chase JG. et al. Lumped parameter and feedback control models of the auto-regulatory response in the circle of Willis. Computer methods in biomechanics and biomedical engineering. 2004;7(3):121–130. doi: 10.1080/10255840410001710894.
14)
Hillen B, Hoogstraten HW, Post L. A mathematical model of the flow in the circle of Willis. Journal of biomechanics. 1986;19(3):187–194. doi: 10.1016/0021-9290(86)90151-X.
15)
Saba L, Raz E, Fatterpekar G, Montisci R, di Martino M, Bassareo PP, Piga M. Correlation between Leukoaraiosis Volume and Circle of Willis Variants. J Neuroimaging. 2015 Mar;25(2):226-31. doi: 10.1111/jon.12103. Epub 2014 Mar 5. PubMed PMID: 24593769.
16)
Seibert J. J., Glasier C. M., Kirby R. S., et al. Transcranial Doppler, MRA, and MRI as a screening examination for cerebrovascular disease in patients with sickle cell anemia: an 8-year study. Pediatric Radiology. 1998;28(3):138–142. doi: 10.1007/s002470050314.
17)
Gahn G., Gerber J., Hallmeyer S., et al. Contrast-enhanced transcranial color-coded duplexsonography in stroke patients with limited bone windows. The American Journal of Neuroradiology. 2000;21(3):509–514.
18)
Razumovsky A. Y., Gillard J. H., Bryan R. N., Hanley D. F., Oppenheimer S. M. TCD, MRA and MRI in acute cerebral ischemia. Acta Neurologica Scandinavica. 1999;99(1):65–76.
19)
Qiu C, Zhang Y, Xue C, Jiang S, Zhang W. MRA study on variation of the circle of willis in healthy Chinese male adults. Biomed Res Int. 2015;2015:976340. doi: 10.1155/2015/976340. Epub 2015 Jan 5. PubMed PMID: 25629057; PubMed Central PMCID: PMC4299360.
20)
Goerlitz J, Wenz H, Al-Zghloul M, Kerl HU, Groden C, Förster A. Anatomical Variations in the Posterior Circle of Willis and Vascular Pathologies in Isolated Unilateral Thalamic Infarction. J Neuroimaging. 2015 Mar 19. doi: 10.1111/jon.12235. [Epub ahead of print] PubMed PMID: 25786673.
circle_of_willis.txt · Last modified: 2017/08/03 23:20 by administrador