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diabetes_mellitus

Diabetes mellitus

see Diabetic stroke.


The prevalence of both Alzheimer disease (AD) and vascular dementia (VaD) is increasing with the aging of the population. Studies from the last several years have shown that people with diabetes have an increased risk for dementia and cognitive impairment. Therefore, the authors of this consensus review tried to elaborate on the role of diabetes, especially diabetes type 2 (T2DM) in both AD and VaD. Based on the clinical and experimental work of scientists from 18 countries participating in the International Congress on Vascular Disorders and on literature search using PUBMED, it can be concluded that T2DM is a risk factor for both, AD and VaD, based on a pathology of glucose utilization. This pathology is the consequence of a disturbance of insulin-related mechanisms leading to brain insulin resistance. Although the underlying pathological mechanisms for AD and VaD are different in many aspects, the contribution of T2DM and insulin resistant brain state (IRBS) to cerebrovascular disturbances in both disorders cannot be neglected. Therefore, early diagnosis of metabolic parameters including those relevant for T2DM is required. Moreover, it is possible that therapeutic options utilized today for diabetes treatment may also have an effect on the risk for dementia. T2DM/IRBS contribute to pathological processes in AD and VaD 1).


Data suggest that diabetes in Chinese patients with intracerebral hemorrhage (ICH) is not associated with increased mortality or functional outcome. Future studies are needed to clarify possible confounders affecting prognosis after ICH 2).

1)
Riederer P, Korczyn AD, Ali SS, Bajenaru O, Choi MS, Chopp M, Dermanovic-Dobrota V, Grünblatt E, Jellinger KA, Kamal MA, Kamal W, Leszek J, Sheldrick-Michel TM, Mushtaq G, Meglic B, Natovich R, Pirtosek Z, Rakusa M, Salkovic-Petrisic M, Schmidt R, Schmitt A, Sridhar GR, Vécsei L, Wojszel ZB, Yaman H, Zhang ZG, Cukierman-Yaffe T. The diabetic brain and cognition. J Neural Transm (Vienna). 2017 Aug 1. doi: 10.1007/s00702-017-1763-2. [Epub ahead of print] Review. PubMed PMID: 28766040.
2)
Wang Q, Wang D, Liu M, Fang Y, You C, Dong W, Chang X, Lei C, Zhang J, Chen Y. Is diabetes a predictor of worse outcome for spontaneous intracerebral hemorrhage? Clin Neurol Neurosurg. 2015 Feb 12;134:67-71. doi: 10.1016/j.clineuro.2015.01.020. [Epub ahead of print] PubMed PMID: 25950926.
diabetes_mellitus.txt · Last modified: 2018/01/01 14:06 by administrador