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endothelial_cell

Endothelial cell

The capillary bed of the brain is comprised of a dense network of intercommunicating vessels that consist of specialized endothelial cells and no smooth muscle.


Endothelial cell coverage along the Pipeline embolization device (PED) is one of two primary proposed mechanisms of action of the device, along with induction of intra-aneurysmal thrombosis 1).


In high grade gliomas, endothelial cell proliferation is 40-fold greater than that of normal brain tissue 2).

Angiopoietin 2 protein was detected not only in endothelial cells but also in glioma cells, and its expression was prominent in both the area surrounding the necrosis and the periphery of glioblastomas.

1)
Ravindran K, DiStasio M, Laham R, Ogilvy CS, Thomas AJ, VanderLaan PA, Alturki AY. Histopathological demonstration of subacute endothelialization following aneurysm re-treatment with the Pipeline embolization device. World Neurosurg. 2018 Jul 18. pii: S1878-8750(18)31568-7. doi: 10.1016/j.wneu.2018.07.090. [Epub ahead of print] PubMed PMID: 30031197.
2)
Plate KH. Mechanisms of angiogenesis in the brain. J Neuropathol Exp Neurol. 1999;58:313–320.
endothelial_cell.txt · Last modified: 2018/07/22 13:28 by administrador