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granulocytic_sarcoma

Intracranial granulocytic sarcomas are rare tumors, which are composed of immature granulocytes. Although it has been well known that these tumors are associated with acute myeloblastic leukemia (AML), they have been almost always related to bone marrow relapse. However, isolated recurrence of granulocytic sarcoma following complete remission from prior AML is extremely rare, especially in the central nervous system. A 44-year-old male presented with isolated recurrence of granulocytic sarcoma mimicking a falx meningioma two years after complete remission by allogenic peripheral blood stem cell transfusion (PBSCT) in the acute myelomonoblastic leukemia (FAB, M4). Because of depressed mental state and mass effect, total surgical resection was performed. Pathological findings were compatible with the granulocytic sarcoma. There was no evidence of leukemic relapse in the peripheral blood. We suggest that this phenomenon can be explained by the hypothesis that a certain barrier effect such as blood brain barrier might lead to the proliferation of intracranial leukemic cells which metastasized before PBSCT 1).

1)
Cho WH, Choi YJ, Choi BK, Cha SH. Isolated recurrence of intracranial granulocytic sarcoma mimicking a falx meningioma in acute myeloblastic leukemia. J Korean Neurosurg Soc. 2010 May;47(5):385-8. doi: 10.3340/jkns.2010.47.5.385. Epub 2010 May 31. PubMed PMID: 20539800; PubMed Central PMCID: PMC2883061.
granulocytic_sarcoma.txt · Last modified: 2016/06/19 11:39 (external edit)