Lymphocyte-depleted Hodgkin's lymphoma is the rarest form of classical Hodgkin's lymphoma, accounting for < 1% of all cases.
Kasper et al., first reported the case of a primary lymphocyte-depleted Hodgkin lymphoma presenting as epidural spinal cord compression. The report, in conjunction with a review of the literature, suggests that surgical intervention is clearly indicated in de novo disease followed by radiotherapy 1).
Hodgkin disease with spinal cord compression
Spinal cord or root compression is a rare complication and usually seen in the setting of progressive, advanced disease.
Gupta et al. report 2 cases of Hodgkin disease in pediatric patients who presented with neurologic signs. One patient had paravertebral masses and involvement of thoracic vertebrae, which was initially misdiagnosed as spinal tuberculosis. The second patient who presented with paraplegia and bladder and bowel involvement had an epidural mass with collapse of thoracic vertebra. Lymph node biopsy revealed Hodgkin disease, mixed cellularity in both the cases. Both were treated with chemotherapy followed by radiotherapy 2).