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Language mapping

Language mapping is often used to protect language functions during surgery for temporal lobe epilepsy or brain tumors.

Language mapping is done during surgery while the patient is awake and interactive. This is possible because the brain itself does not have pain receptors.

The patient is shown sequential pictures of common objects, while a region of the brain is electrically stimulated in one centimeter increments.

When the patient cannot successfully name objects during stimulation of a particular part of the brain, that brain area is concluded to be important for visual object naming.

The widely held belief is that visual object naming is primarily a function of the lateral [outermost] temporal lobe.

In comparison with fMRI, navigated transcranial magnetic stimulation (rTMS) is a more sensitive but less specific tool for preoperative language mapping than direct cortical stimulation DCS.

A wide range of studies on language assessment during awake brain surgery is nowadays available. Yet, a consensus on a standardized protocol for intraoperative language mapping is still lacking. More specifically, very limited information is offered about intraoperative assessment of a crucial component of language such as syntax.

A review of the Epistemogy and Theoretical Syntax Research Center (NETS), Scuola Universitaria Superiore IUSS Pavia, Piazza della Vittoria, 15, 27100, Pavia, Italy and the Unit of Oncological Neurosurgery, Humanitas Research Hospital, 20089 Rozzano, Milan, Italy, aims at critically analyzing the intraoperative studies investigating the cerebral basis of syntactic processing. A comprehensive query was performed on the literature, returning a total of 18 studies. These papers were analyzed according to two complementary criteria, based on the distinction between morphosyntax and syntax. The first criterion focused on the tasks and stimuli employed intraoperatively. Studies were divided into three different groups: group 1 included those studies that overtly aimed at investigating morphosyntactic processes; group 2 included studies that did not explicitly focus on syntax, yet employed stimuli requiring morphosyntactic processing; and group 3 included studies reporting some generic form of syntactic deficit, although not further investigated. The second criterion focused on the syntactic structures of the sentences assessed intraoperatively, analyzing the canonicity of sentence structure (i.e., canonical versus non-canonical word order). The global picture emerging from our analysis indicates that what was investigated in the intraoperative literature is morphosyntactic processing, rather than pure syntax. The study of the neurobiology of syntax during awake surgery seems thus to be still at an early stage, in need of systematic, linguistically grounded investigations 1).

A study describes development of a novel language mapping approach using high-γ modulation in electrocorticography (ECoG) during spontaneous conversation, and its comparison with electrical cortical stimulation (ECS) in childhood-onset drug-resistant epilepsy.

This study supports the feasibility of language mapping with ECoG HGS during spontaneous conversation, and its accuracy compared to traditional ECS. Given long-standing concerns about ecological validity of ECS mapping of cued language tasks, and difficulties encountered with its use in children, ECoG mapping of spontaneous language may provide a valid alternative for clinical use 2).

Repetitive navigated transcranial magnetic stimulation (rTMS) is now increasingly used for preoperative language mapping in patients with lesions in language-related areas of the brain. Yet its correlation with intraoperative direct cortical stimulation (DCS) has to be improved.

Although language mapping by repetitive navigated transcranial magnetic stimulation (rTMS) gains importance in neuropsychological research and clinical utility, neuroscientists still use different mapping protocols including different stimulation frequencies.

The stimulation frequency has to be adapted to the aim of the rTMS language investigation 3).

Signal dropouts and distortions caused by susceptibility effects in the current standard echo planar imaging (EPI)-based fMRI images are well-known problems and pose a major hurdle for the application of fMRI in several brain regions, many of which are related to language mapping in presurgical planning. Such artifacts are particularly problematic in patients with previous surgical resection cavities, craniotomy hardware, hemorrhage, and vascular malformation. A recently developed T2-prepared (T2prep) fMRI approach showed negligible distortion and dropouts in the entire brain even in the presence of large susceptibility effects. Here, we present initial results comparing T2prep- and multiband EPI-fMRI scans for presurgical language mapping using a sentence completion task in patients with brain tumor and epilepsy. In all patients scanned, T2prep-fMRI showed minimal image artifacts (distortion and dropout) and greater functional sensitivity than EPI-fMRI around the lesions containing blood products and in air-filled cavities. This enhanced sensitivity in T2prep-fMRI was also evidenced by the fact that functional activation during the sentence completion task was detected with T2prep-fMRI but not with EPI-fMRI in the affected areas with the same statistical threshold, whereas cerebrovascular reactivity during a breath-hold task was preserved in these same regions, implying intact neurovascular coupling in these patients. Although further investigations are required to validate these findings with invasive methods such as direct cortical stimulation mapping as the gold standard, this approach provides an alternative method for performing fMRI in brain regions with large susceptibility effects 4).

Zanin E, Riva M, Bambini V, Cappa SF, Magrassi L, Moro A. The contribution of surgical brain mapping to the understanding of the anatomo-functional basis of syntax: A critical review. Neurol Sci. 2017 Jun 17. doi: 10.1007/s10072-017-3016-4. [Epub ahead of print] Review. PubMed PMID: 28624915.
Arya R, Wilson JA, Vannest J, Byars AW, Greiner HM, Buroker J, Fujiwara H, Mangano FT, Holland KD, Horn PS, Crone NE, Rose DF. Electrocorticographic language mapping in children by high-gamma synchronization during spontaneous conversation: Comparison with conventional electrical cortical stimulation. Epilepsy Res. 2015 Feb;110:78-87. doi: 10.1016/j.eplepsyres.2014.11.013. Epub 2014 Nov 22. PubMed PMID: 25616459.
Hauck T, Tanigawa N, Probst M, Wohlschlaeger A, Ille S, Sollmann N, Maurer S, Zimmer C, Ringel F, Meyer B, Krieg SM. Stimulation frequency determines the distribution of language positive cortical regions during navigated transcranial magnetic brain stimulation. BMC Neurosci. 2015 Feb 18;16(1):5. PubMed PMID: 25880838.
Hua J, Miao X, Agarwal S, Bettegowda C, Quiñones-Hinojosa A, Laterra J, Van Zijl PCM, Pekar JJ, Pillai JJ. Language Mapping Using T2-Prepared BOLD Functional MRI in the Presence of Large Susceptibility Artifacts-Initial Results in Patients With Brain Tumor and Epilepsy. Tomography. 2017 Jun;3(2):105-113. doi: 10.18383/j.tom.2017.00006. PubMed PMID: 28804779; PubMed Central PMCID: PMC5552052.
language_mapping.txt · Last modified: 2017/08/15 22:54 by administrador