see Viral meningitis.
The responsible pathogens of nosocomial meningitis are quite different from community-acquired meningitis with high rates of morbidity and mortality.
Post-neurosurgical meningitis usually occurs in the autumn and winter of the year in Beijing Tian Tan Hospital, Capital Medical University, Beijing, China;. Gram-positive organisms, which are sensitive to compound sulfamethoxazole and vancomycin, are the most common causative pathogens of post-neurosurgical meningitis in the northern mainland of China 1).
Occurs in 25-50% of untreated traumatic cerebrospinal fluid fistula (CSF) and in 10% of patients in the first week after trauma with head injury.
The diagnosis of external ventricular drain EVD-related ventriculo-meningitis in neurosurgical ICU patients can be established in a rapid manner using a multiplex real-time polymerase chain reaction (PCR) assay on cerebrospinal fluid (CSF) samples in combination with intrathecal biomarkers 2).
Imaging findings are mostly nonspecific with respect to the causative pathogen 3).
Enterovirus detection in cerebrospinal fluid was effective to differentiate bacterial meningitis from viral meningitis. When the test was analyzed together with the Bacterial Meningitis Score, specificity was higher when compared to Bacterial Meningitis Score alone 4).
The most important prognostic factor is the appropriate choice of pathogen-specific antibacterial therapy
A 75 year-old-man was operated for a glioblastoma with no evident signs of primary infection in the wound site. Eight days after surgery the patient developed signs and symptoms of meningitis. Caulobacter was then isolated on three separate occasions in the patient's cerebrospinal fluid (CSF). Thereafter, specific antibiotic therapy began. After two weeks of therapy the patient was discharged with complete resolution of any related symptoms.