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middle_cerebral_artery_bifurcation_aneurysm

Middle cerebral artery bifurcation aneurysm

Of the middle cerebral artery aneurysms, those located at the main bifurcation of the middle cerebral artery (MCA) (MbifA) are by far the most frequent.

Middle cerebral artery bifurcation aneurysms are often broad necked and may involve one or both branches of the bifurcation (M2s). The anatomical and hemodynamic features of MbifAs make them usually more favorable for microneurosurgical treatment. In population-based services, MbifAs are frequent targets of elective surgery (unruptured), acute surgery (ruptured), and emergency surgery (large ICH), even advanced approaches (giant). The challenge is to clip the neck adequately, without neck remnants, while preserving the bifurcational flow 1).


In the series of Elsharkawy et al. the main MCA bifurcation was the most common location for MCA aneurysms, harboring 829 aneurysms (63%). The 406 M1 aneurysms comprised 242 M1 early cortical branch aneurysms (60%) and 164 M1 lenticulostriate artery aneurysms (40%). We found 106 MCA aneurysms (8%) at the origin of large early frontal branches simulating M2 trunks liable to be misclassified as MCA bifurcation aneurysms. Even though 51% of the 407 ruptured MCA aneurysms were associated with an intracerebral hematoma, this did not affect the classification.

Studying MCA angioarchitecture and applying the 4-group classification of MCA aneurysms is practical and facilitates the accurate classification of MCA aneurysms, helping to improve surgical outcome. 2).


From the analysis of 61 MCA bifurcation aneurysms, 4 shape pattern categories were created that allowed the classification of 56 aneurysms (91.8%). The number of aneurysms allotted to each shape cluster was 10 (16.4%) in category 1, 24 (39.3%) in category 2, 7 (11.5%) in category 3, and 15 (24.6%) in category 4.

Through the use of anatomic visual cues, MCA bifurcation aneurysms can be grouped into a small number of shape patterns with an associated clip solution. Implementing these principles within current neurosurgery training paradigms can provide a tool that allows more efficient transition from novice to cerebrovascular expert 3).

While most aneurysms that originate at the middle cerebral artery (MCA) bifurcation or trifurcation have a saccular geometry, some MCA aneurysms may exhibit a fusiform morphology and incorporate not only the proximal MCA trunk but also major MCA branches. In contrast to saccular aneurysms, fusiform aneurysms represent a distinct subset of intracranial aneurysms with unique underlying pathological features, hemodynamic forces, anatomical distribution, as well as natural history that governs their treatment. 4).

Case series

2017

Forty patients with 46 middle cerebral artery bifurcation aneurysms were treated microsurgically by the same surgeon. Aneurysms were classified according to shape and the Fisher test was applied to analyze the effect of morphology on the pre-operative and intra-operative rupture. Results:

Pre-operative and intra-operative ruptures were observed in 8/46 patients (17.4%) and 14/46 patients (30.4%) respectively. Thirty-two cases (69.6%) had no symptoms postoperatively, modified Rankin score (MRS) of 0; 6.5% had MRS of 1 (no significant disability); 13% had MRS of 2 (slight disability); 4.3% had moderately severe disability (MRS of 4); and there were 3 deaths (6.5%) post-operatively. The morphology was not directly related to the rupture rate. Conclusion:

In general, ruptures are not affected by the morphology or the studied variables. Larger series are needed to validate these outcomes 5).

2016

A total of 169 consecutive patients with 177 bifurcation-type MCAAs were reviewed from August 2011 to January 2016. Based on the clinical and morphologic characteristics findings, the risk factors of aneurysm rupture were assessed using statistical methods.

Age, cerebral atherosclerosis, no hypertension, hypertension grade 2 and coronary artery disease (CAD) were negatively correlated with aneurysm rupture. The mean diameter (MD) of the parent and two daughter arteries was negatively correlated with rupture. Aneurysms with irregularity, depth, width, maximum size, aspect ratio, depth-to-width ratio, bottleneck factor, and size ratio were positively correlated with rupture. The multivariate logistic regression model revealed that irregular shape (odds ratio (OR) 2.697) and aspect ratio (OR 3.723) were significantly and positively correlated with rupture, while cerebral atherosclerosis (OR 0.033), CAD (OR 0.080), and MD (OR 0.201) were negatively correlated with rupture. Receiver operating characteristic analysis revealed that the threshold value of the aspect ratio and MD were 0.96 and 2.43 mm, respectively.

Cerebral atherosclerosis and CAD are protective factors against rupture. Morphological characteristics such as an aneurysm with an irregular shape, a high aspect ratio (>0.96) and a small MD (<2.43 mm) are likely better predictors of rupture 6).

Videos

Technical nuances of clipping a middle cerebral artery bifurcation aneurysm

1)
Dashti R, Hernesniemi J, Niemelä M, Rinne J, Porras M, Lehecka M, Shen H, Albayrak BS, Lehto H, Koroknay-Pál P, de Oliveira RS, Perra G, Ronkainen A, Koivisto T, Jääskeläinen JE. Microneurosurgical management of middle cerebral artery bifurcation aneurysms. Surg Neurol. 2007 May;67(5):441-56. Review. PubMed PMID: 17445599.
2)
Elsharkawy A, Lehečka M, Niemelä M, Billon-Grand R, Lehto H, Kivisaari R, Hernesniemi J. A new, more accurate classification of middle cerebral artery aneurysms: computed tomography angiographic study of 1,009 consecutive cases with 1,309 middle cerebral artery aneurysms. Neurosurgery. 2013 Jul;73(1):94-102; discussion 102. doi: 10.1227/01.neu.0000429842.61213.d5. PubMed PMID: 23615110.
3)
Washington CW, Ju T, Zipfel GJ, Dacey RG Jr. Middle cerebral artery bifurcation aneurysms: an anatomic classification scheme for planning optimal surgical strategies. Neurosurgery. 2014 Mar;10 Suppl 1:145-53; discussion 153-5. doi: 10.1227/NEU.0000000000000250. PubMed PMID: 24226424.
4)
Pabaney AH, Mazaris PA, Kole MK, Reinard KA. Endovascular management of fusiform aneurysm of anterior temporal artery: Technical report. Surg Neurol Int. 2015 Jul 20;6:119. doi: 10.4103/2152-7806.161239. eCollection 2015. PubMed PMID: 26290771; PubMed Central PMCID: PMC4521225.
5)
Estevão IA, Camporeze B, Araujo AS Jr, Nery B, Antunes ÁCM, Smith TR, Aguiar PHP. Middle cerebral artery aneurysms: aneurysm angiographic morphology and its relation to pre-operative and intra-operative rupture. Arq Neuropsiquiatr. 2017 Aug;75(8):523-532. doi: 10.1590/0004-282×20170082. PubMed PMID: 28813082.
6)
Wang GX, Yu JY, Wen L, Zhang L, Mou KJ, Zhang D. Risk Factors for the Rupture of Middle Cerebral Artery Bifurcation Aneurysms Using CT Angiography. PLoS One. 2016 Dec 15;11(12):e0166654. doi: 10.1371/journal.pone.0166654. PubMed PMID: 27977691.
middle_cerebral_artery_bifurcation_aneurysm.txt · Last modified: 2017/08/17 12:13 by administrador