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Neural stem cell

Neural stem cells (NSCs) are self-renewing, multipotent cells that generate the main phenotype of the nervous system. Stem cells are characterized by their capability to differentiate into multiple cell types via exogenous stimuli from their environment.

see neural stem cell division.


Compared with other types of stem cells, adult neural stem cells (aNSCs) have clinical advantages, such as limited proliferation, inborn differentiation potential into functional neural cells, and no ethical issues. In spite of the merits of aNSCs, difficulties in the isolation from the normal brain, and in the in vitro expansion, have blocked preclinical and clinical study using aNSCs.

Several groups have recently developed novel techniques to isolate and expand aNSCs from normal adult brains, and showed successful applications of aNSCs to neurological diseases. With new technologies for aNSCs and their clinical strengths, previous hurdles in stem cell therapies for neurological diseases could be overcome, to realize clinically efficacious regenerative stem cell therapeutics 1).


In neurooncology, the biology of neural stem cells (NSCs) has been pursued in two ways: as tumor-initiating cells (TICs) and as a potential cell-based vehicle for gene therapy.

NSCs as well as mesenchymal stem cells (MSCs) have been reported to possess tumor tropism capacities.

see Induced neural stem cells

1)
Nam H, Lee KH, Nam DH, Joo KM. Adult human neural stem cell therapeutics: Current developmental status and prospect. World J Stem Cells. 2015 Jan 26;7(1):126-136. Review. PubMed PMID: 25621112.
neural_stem_cell.txt · Last modified: 2018/02/12 23:33 by administrador