User Tools

Site Tools


platelet_derived_growth_factor_receptor

Platelet derived growth factor receptor

Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer.

There are two forms of the PDGF-R, alpha and beta each encoded by a different gene.

Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes.


DNA Methylation of the PDGFD Gene Promoter Increases the Risk for Intracranial Aneurysms and Brain Arteriovenous Malformations 1).


Current standard treatment for glioma patients is surgical removal followed by radiotherapy and adjuvant chemotherapy. Due to therapeutic resistance and tumor recurrence, efforts are ongoing to identify the molecules that are fundamental to regulate the tumor progression and provide additional methods for individual treatment of glioma patients. By studying the initiation and maintenance of glioma, studies focused on the targets of tyrosine kinase receptors including EGFR, PDGFR and other crucial signal pathways such as PI3K/AKT and RAS/RAF/MAPK pathway. Furthermore, recent advances in targeting immunotherapy and stem cell therapy also brought numerous strategies to glioma treatment 2).

1)
Zhou S, Gao X, Sun J, Lin Z, Huang Y. DNA Methylation of the PDGFD Gene Promoter Increases the Risk for Intracranial Aneurysms and Brain Arteriovenous Malformations. DNA Cell Biol. 2017 Mar 27. doi: 10.1089/dna.2016.3499. [Epub ahead of print] PubMed PMID: 28346846.
2)
Lin L, Cai J, Jiang C. Recent advances in targeted therapy for glioma. Curr Med Chem. 2016 Dec 23. [Epub ahead of print] PubMed PMID: 28019637.
platelet_derived_growth_factor_receptor.txt · Last modified: 2017/03/28 18:08 by administrador