User Tools

Site Tools


posterior_fossa_tumor_in_children

Posterior fossa tumor in children

The posterior fossa tumor in children are:

Posterior fossa astrocytoma

Cerebellar pilocytic astrocytoma: most common

Brainstem glioma

Medulloblastoma: (also known as posterior fossa PNET)

Infratentorial Ependymoma

Atypical teratoid rhabdoid tumor (AT/RT)

Hemangioblastoma (uncommon except in patients with vHL)

Posterior fossa teratoma

A quick and handy mnemonic for posterior fossa tumours in children is BEAM.

Although it is true that posterior fossa tumours are much more common in children than in adults the distribution does vary with age:

0 to 3 years of age: supratentorial > infratentorial

4 to 10 years of age: infratentorial > supratentorial

10 to early adult hood: infratentorial = supratentorial

adults: supratentorial > infratentorial

Overall 50-55% of all intracranial tumors in children are found in the posterior fossa.

Treatment

A developmental and anatomic approach to the posterior fossa tumors in children (together with diffusion imaging data) provides a reliable pre-surgical identification of the tumor and of its aggressiveness 1).

Complications

Outcome

Over the last decades, the mortality rate of children with posterior fossa tumors has gradually decreased. While survival has been the primary objective in most reports, quality of survival increasingly appears to be an important indicator of a successful outcome. Children with a PF tumor can sustain damage to the cerebellum and other brain structures from the tumor itself, concomitant hydrocephalus, the consequences of treatment (surgery, chemotherapy, radiotherapy), or a combination of these factors. Together, these contribute to long-term sequelae in physical functioning, neuropsychological late outcomes (including academic outcome, working memory, perception and estimation of time, and selective attention, long-term neuromotor speech deficits, and executive functioning). Long-term quality of life can also be affected by endocrinological complication or the occurrence of secondary tumors. A significant proportion of survivors of PF tumors require long-term special education services and have reduced rates of high school graduation and employment. Interventions to improve neuropsychological functioning in childhood PF tumor survivors include (1) pharmacological interventions (such as methylphenidate, modafinil, or donepezil), (2) cognitive remediation, and (3) home-based computerized cognitive training. In order to achieve the best possible outcome for survivors, and ultimately minimize long-term complications, new interventions must be developed to prevent and ameliorate the neuro-toxic effects experienced by these children 2).

Age at diagnosis and treatment factors are important variables that affect the outcomes of the survivors 3)

1)
Raybaud C, Ramaswamy V, Taylor MD, Laughlin S. Posterior fossa tumors in children: developmental anatomy and diagnostic imaging. Childs Nerv Syst. 2015 Oct;31(10):1661-76. doi: 10.1007/s00381-015-2834-z. Epub 2015 Sep 9. PubMed PMID: 26351220.
2)
Lassaletta A, Bouffet E, Mabbott D, Kulkarni AV. Functional and neuropsychological late outcomes in posterior fossa tumors in children. Childs Nerv Syst. 2015 Oct;31(10):1877-90. doi: 10.1007/s00381-015-2829-9. Epub 2015 Sep 9. PubMed PMID: 26351237.
3)
Hanzlik E, Woodrome SE, Abdel-Baki M, Geller TJ, Elbabaa SK. A systematic review of neuropsychological outcomes following posterior fossa tumor surgery in children. Childs Nerv Syst. 2015 Oct;31(10):1869-75. doi: 10.1007/s00381-015-2867-3. Epub 2015 Sep 9. PubMed PMID: 26351236.
posterior_fossa_tumor_in_children.txt · Last modified: 2018/11/15 00:34 by administrador