User Tools

Site Tools


schwannoma

Schwannoma

Schwannomas are benign tumors that are typically round, well demarcated, and encapsulated, composed of Schwann cells; the tumors can grow anywhere throughout the nervous system that contains Schwann cells.

The absence of the protein NF2/Merlin causes an uninterrupted cell proliferation cascade originating from an abnormal interaction between an extracellular mucopolysaccharide, hyaluronan (HA), and schwann cell surface CD44 receptor, which has been identified as one of the central causative factors for schwannoma 1).

It has been described that a schwannoma may display variable degenerative changes such as fibrosis, cytological atypia, calcification, hemorrhage, or cystic formations 2).

Intracranial schwannoma.

Spinal schwannoma.

Cystic degenerations occurring in schwannomas are found in schwannomas of the orbital region, olfactory groove, tentorial hiatus, posterior cavernous sinus, presacral region, maxillary sinus, intramedullary spinal region, or intraventicular region 3).

1)
Ariyannur PS, Vikkath N, Pillai AB. Cerebrospinal Fluid Hyaluronan and Neurofibromatosis Type 2. Cancer Microenviron. 2018 Aug 25. doi: 10.1007/s12307-018-0216-2. [Epub ahead of print] PubMed PMID: 30145722.
2) , 3)
Borges G, Bonilha L, Proa M Jr, Fernandes YB, Ramina R, Zanardi V, et al. Imaging features and treatment of an intradural lumbar cystic schwannoma. Arq Neuropsiquiatr 2005; 63: 681-684.
schwannoma.txt · Last modified: 2018/09/23 19:49 by administrador