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surgical_site_infection

Surgical site infection (SSI)

see also Spinal infection.

A surgical site infection is an infection that occurs after surgery in the part of the body where the surgery took place.

Surgical site infections pose a significant problem in the treatment of neurosurgical procedures, regardless of the application of perioperative prophylaxis with systemic antibiotics. The infection rate in these procedures ranges from less than 1% to above 15%

Today’s health care environment demands more than ever of surgeons and the hospitals they work in. Payors, including Medicare, increasingly refuse to pay for treating complications deemed preventable, such as surgical site infections.

Neurosurgical wound infections are the most common and serious complications resulting in increased rates of morbidity and mortality 1).

Active outpatient follow-up is not necessary and monitoring of inpatients and readmissions is enough for a cranial neurosurgical SSI programme 2).

Epidemiology

Several studies had been reported lower incidence of neurosurgical wound infection 3) 4).

The neurosurgical wound infection rate is usually low even in developing countries and remains within the accepted rate 5).


Predictors of SSI and hospital readmission differ in the US, Denmark and Japan, suggesting that risk stratification models may need to be population specific or adjusted. Some differences in measured parameters exist in the 3 databases analyzed, however, patient and procedure selection also appear to differ and may limit the ability to directly pool data from different regions. Therefore, risk stratification models developed in one country may not be directly applicable to other countries 6).

Classification

SSIs are classified into incisional SSIs, which can be superficial or deep, and organ/space SSIs, which affect the rest of the body other than the body wall layers.

These classifications are defined as follows:

Superficial incisional SSI - Infection involves only skin and subcutaneous tissue of incision

Deep incisional SSI - Infection involves deep tissues, such as fascial and muscle layers; this also includes infection involving both superficial and deep incision sites and organ/space SSI draining through incision.

see Deep wound infection

Organ/space SSI - Infection involves any part of the anatomy in organs and spaces other than the incision, which was opened or manipulated during operation.

see also Spinal instrumentation infection.

Etiology

Surgical site infections (SSIs) are potential complications occurring after surgery. Despite the availability of prophylactic antibiotics and aseptic technique, they remain a cause for concern 7) 8).

Microorganisms

The most common microorganisms isolated from SSI were Staphylococcus aureus (23%), Enterobacteriaceae (21%), and Propionibacterium acnes (12%) 9).

The leading causal agent of SSI after spine operations is Staphylococcus aureus 10).

Risk factors

Cassir et al. identified the following independent risk factors for SSI postcranial surgery: intensive care unit (ICU) length of stay ≥7 days (odds ratio [OR] = 6.1; 95% confidence interval [CI], 1.7-21.7), duration of drainage ≥3 days (OR = 3.3; 95% CI, 1.1-11), and cerebrospinal fluid leakage (OR = 5.6; 95% CI, 1.1-30).

For SSIs postspinal surgery, they identified the following: ICU length of stay ≥7 days (OR = 7.2; 95% CI, 1.6-32.1), coinfection (OR = 9.9; 95% CI, 2.2-43.4), and duration of drainage ≥3 days (OR = 5.7; 95% CI, 1.5-22) 11).


A study found that patient body mass index and male sex were associated with an increased risk of SSI. Operating room personnel turnover, a modifiable, work flow-related factor, was an independent variable positively correlated with SSI. This study suggests that efforts to reduce operating room turnover may be effective in preventing SSI 12).

Diagnosis

A wound infection can manifest itself by local symptoms, for example, by suppuration, or by general symptoms, for example, by fever, weakness, or posttraumatic sepsis.

Diagnosis of surgical site infection appears to rely primarily on clinical factors and laboratory values, such as C-Reactive Protein, are not universally sensitive. Similarly, novel methods of perioperative infection prophylaxis such as local antibiotic administration appear to be modestly effective.

Surgical site infections are a common, multifactorial problem after spine surgery. There is compelling evidence that improved risk stratification, detection, and prevention will reduce surgical site infections 13).

SSI and bone flap resorption are the most frequent complications associated with the reimplantation of autologous cryopreserved bone after decompressive craniectomy. Prolonged procedural time and cardiovascular comorbidity tend to increase the risk of SSI 14).

Complications

Sepsis and tetanus are severe forms of general wound infection. Causative agents include staphylococci, Pseudomonas aeruginosa, and colon bacillus. Associations of these microorganisms are frequently observed. The causative agents of anaerobic infection are less commonly observed. Microorganisms always penetrate a wound, although infection rarely develops if the body and injured tissues are adequately resistant and primary surgical treatment is prompt.

Prevention of a wound infection depends on adequate primary surgical treatment of a wound. Treatment is aimed at suppressing the development of infection through administration of antibiotics and other antimicrobial preparations and at strengthening the defensive mechanisms of the afflicted individual; an adequate diet, transfusions of blood and protein preparations, and the administration of specific serums, toxoids, autovaccines, and gamma globulin serve the latter purpose.

Prevention

Different antibiotics and administration regimes have been used in the perioperative prophylaxis so far, and there are numerous comparative studies regarding their efficiency, however, it is generally indicated that the choice thereof should be based on information and local specifics connected to the most probable bacterial causers, which would possibly contaminate the surgical site and cause infection, and moreover, the mandatory compliance with the principles of providing adequate concentration of the drug at the time of the anticipated contamination.

Administration of parenteral antibiotics before surgery reduces the incidence of postoperative infections after neurosurgical procedures, especially in cases with increased risk factors for SSI, such as ACA score of ≥ 2/3, the duration of the surgical intervention ≥ 4 hours, contaminated wound and comorbidities. Perioperative antibiotic prophylaxis should be directed to better coverage of the S.aureus arrays. 15).

The invasive nature of surgery carries high risk for the transfer of pathogens responsible for surgical site infections (SSI).


Since the pioneering study of Mallis 16) who reported the beneficial effects of local and preoperative antibiotic prophylaxis in clean neurosurgical wound infection, many randomized and meta-analysis studies confirmed the benefit of antibiotic prophylaxis in reducing the incidence of surgical site infection 17) 18) 19) 20) 21).

The protocol of antibiotic prophylaxis is different among centers and the majority of previous publications came from The United States or Europe and rarely from developing countries.


The available evidence to assess the effect of wearing additional gloves, intraoperative glove change or type of gloves on SSI rates is very limited and of low-quality. Our findings indicate the need for RCTs on this topic 22).


Double gloving is the practice of wearing two layers of medical gloves to reduce the danger of infection from glove failure or penetration of the gloves by sharp objects during medical procedures. A systematic review of the literature has shown double gloving to offer significantly more protection against inner glove perforation in surgical procedures compared to the use of a single glove layer 23) 24).


The local application of powdered vancomycin was not associated with a significant difference in the rate of deep SSI after spinal deformity surgery, and other treatment modalities are necessary to limit infection for this high-risk group. This study is in contrary to prior studies, which have reported a decrease in SSI with vancomycin powder.Level of Evidence: 2 25).


Drain tip culture had a high positivity rate in the SSI group and the coincidence rate for the causative pathogen was relatively high 26).

Case series

2016

An observational, prospective study was conducted of the rates of surgical wound infection among patients admitted for more than 48 h to the Neurosurgery Department of Ramon y Cajal University Hospital , Madrid , Spain (a tertiary-level university hospital) between July 2011 and December 2014.

The study surveyed a total of 536 surgical procedures performed in 521 patients. The rate of diagnosed surgical site infection (SSI) was 4.85% (26 infections), below the established acceptable threshold of 5%. Of these, 65.38% were organ-space infections, 30.77% deep infections, and 7.69% superficial infections. Infection rates for each type of surgical procedure were 4.35% for spinal fusion, 0.00% for refusion of spine, 2.08% for laminectomy, 5.95% for ventricular shunt, and 5.14% for craniotomy. Antibiotic prophylaxis was evaluated as suitable in 80.22% of surgical procedures.

Infection rates were lower when the surgery was elective, clean, the patient had a lower ASA, and when suitable antimicrobial prophylaxis was administered. The rate of suitable antimicrobial prophylaxis shows that there is room for improvement. In order to minimize the risk of surgical wound infection, all professionals involved in patient care need to know and apply current recommendations, especially those relating to proper hand hygiene and suitable antibiotic prophylaxis 27).


One thousand thirty (N=1,030) patients were included in the study. All subjects underwent primary lumbar single- or two-level decompression, microdiscectomy, or instrumented fusion. OUTCOME MEASURES: Occurrence of an SSI defined according to the current Centers for Disease Control and Prevention guidelines that required surgical or nonsurgical therapy. METHODS: The effect of preoperative patient characteristics, comorbidities, disease history, and invasiveness of the elective surgery on the risk of SSI was determined in uni- and multivariate logistic regression models in the test cohort (N=723). The performance of the final multivariable regression model was assessed by measuring its discriminative ability (c-index) in receiver operating characteristic analysis. Performance of the multivariable risk estimation model was tested on the validation (N=307) cohort. RESULTS: The prevalence of SSI was 3.5% and 3.9% in the test and in the validation cohorts, respectively. The final multivariable regression model predictive (p=.003) for SSI contained the patient's age, body mass index (BMI), and the presence of 5 comorbidities, such as diabetes, ischemic heart disease, arrhythmia, chronic liver disease, and autoimmune disease as risk factors. The c-index of the model was 0.71, showing good discriminative ability, and it was confirmed by the data of the independent validation cohort (c=0.72).

Predisposing factors for SSI were older age, higher BMI, and the presence of certain comorbidities in the present study. The cumulative number of risk factors significantly associated with the increasing risk for an SSI (p<.0001). Our model needs further validation but it may be used for individual risk assessment and reduction in the future 28).


The full set of prospectively gathered Medicare insurance data (2005-2012) was retrospectively reviewed. Patients who underwent primary lumbar discectomy for lumbar disc herniations from 2009 to quarter 3 of 2012 were selected. This cohort (n = 41,655) was then divided into two subgroups: those who were diagnosed with incidental durotomy on the day of surgery (n = 2,052) and those who were not (control population). To select a more effective control population, patients of a similar age, gender, smoking status, diabetes mellitus status, chronic pulmonary disease status, and body-mass-index were chosen at random from the control population to create a control cohort. In-hospital costs, length of stay, and rates of 30-day readmission, 90-day wound complications, and 90-day serious adverse effects were compared.

An incidental durotomy rate of 4.9% was observed. Higher rates of wound infection (2.4 vs 1.3%; OR 1.88; 95% CI: 1.31 - 2.70; p < 0.001), wound dehiscence (0.9 vs 0.4%; OR 2.39; 95% CI: 1.31 - 4.37; p = 0.004), and serious adverse events related to incidental durotomy (0.9 vs 0.2%; OR 4.10; 95% CI: 2.05 - 8.19; p < 0.0001) were observed in incidental durotomy patients. In-hospital costs were increased by over $4,000 in patients with incidental durotomy (p < 0.0001).

Incidental durotomies occur in almost one in every twenty elderly patients treated with primary lumbar discectomy. Given the increased hospital costs and complication rates, this complication must be viewed as anything but benign 29).


From 152 patients with spinal metastases. Overall surgical site infection SSI rate was 11.2 per 100 patients (9.7 per 100 procedures). An increase in the risk of SSI was observed when surgery involved a greater number of vertebral levels (odds ratio 1.26, p=0.019) when controlling for primary spinal region. Controlling for the number of spinal levels, the odds of SSI increased by a factor of 5.6 (p=0.103) when the primary surgical region was thoracic, as opposed to cervical or lumbar.

In conclusion, surgery associated with multiple vertebral levels for treatment of spinal metastases, particularly of the thoracic spine, is associated with increased risk of SSI 30).

2015

Selby et al., track surgical site infections (SSIs) with two systems; our in-house surgical secondary events (SSE) database and the National Surgical Quality Improvement Project (NSQIP). The SSE database, a modification of the Clavien-Dindo classification, categorizes SSIs by their anatomic site, whereas NSQIP categorizes by their level. Our aim was to directly compare these different definitions.

NSQIP and the SSE database entries for all surgeries performed in 2011 and 2012 were compared. To match NSQIP definitions, and while blinded to NSQIP results, entries in the SSE database were categorized as either incisional (superficial or deep) or organ space infections. These categorizations were compared with NSQIP records; agreement was assessed with Cohen kappa.

The 5028 patients in our cohort had a 6.5% SSI in the SSE database and a 4% rate in NSQIP, with an overall agreement of 95% (kappa = 0.48, P < 0.0001). The rates of categorized infections were similarly well matched; incisional rates of 4.1% and 2.7% for the SSE database and NSQIP and organ space rates of 2.6% and 1.5%. Overall agreements were 96% (kappa = 0.36, P < 0.0001) and 98% (kappa = 0.55, P < 0.0001), respectively. Over 80% of cases recorded by the SSE database but not NSQIP did not meet NSQIP criteria.

The SSE database is an accurate, real-time record of postoperative SSIs. Institutional databases that capture all surgical cases can be used in conjunction with NSQIP with excellent concordance 31).

2012

Scalp wound infections following craniocerebral trauma caused by the Wenchuan earthquake.

A total of 82 patients suffered from scalp trauma in this study, including 52.4% cases (43/82) with wound infections, mostly accompanied by severe foreign body contamination, for which the time of first debridement was significantly delayed. There were 59 strains of infectious pathogenic bacteria. Gram-positive bacteria were the most common organisms found (64.4%), including strains of Staphylococcus aureus (26/59, 44.1%) and strains of Staphylococcus epidermidis (12/59, 20.3%). Gram-negative bacteria accounted for 35.6% of samples: 22.0% (13/59) were strains of Enterobacter cloacae; 5.1% (3/59) were strains of Klebsiella pneumoniae; and 8.5% (5/59) were strains of Serratia rubidaea.

The rate of scalp wound infections following earthquake-induced craniocerebral trauma, which was dominated by Grampositive Staphylococcus aureus infection, has been markedly elevated in recent years. Early debridement and suturing, nutritional support and application of sensitive antibiotics can augment the therapeutic effect 32).

1) , 21)
Lietard C, Thébaud V, Besson G, Lejeune B: Risk factors for neurosurgical site infections: An 18 month prospective study. J Neurosurg 109:729-734, 2008
2)
Davies BM, Jones A, Patel HC. Surgical-site infection surveillance in cranial neurosurgery. Br J Neurosurg. 2015 Aug 27:1-3. [Epub ahead of print] PubMed PMID: 26313320.
3)
McClelland S, Hall WA: Postoperative central nervous system infection: Incidence and associated factors in 2111 neurosur- gical procedures. Clinical Infectious Diseases 45:55-59,2007
4)
Valentini LG, Casali C, Chatenoud L, Chiaffarino F: Surgical site infections after elective neurosurgery: A survey of 1747 patients. Neurosurgery 61:88-96, 2007
5)
Taha MM, Abouhashem S, Abdel-Rahman AY. Neurosurgical wound infection at a university hospital in egypt; prospective study of 1181 patients for 2 years.Turk Neurosurg. 2014;24(1):8-12. doi: 10.5137/1019-5149.JTN.6464-12.1. PubMed PMID: 24535784.
6)
Glassman S, Carreon LY, Andersen M, Asher A, Eiskjær S, Gehrchen M, Imagama S, Ishii K, Kaito T, Matsuyama Y, Moridaira H, Mummaneni P, Shaffrey C, Matsumoto M. Predictors of Hospital Re-admission and Surgical Site Infection in the United States, Denmark and Japan: Is Risk Stratification a Universal Language? Spine (Phila Pa 1976). 2017 Jan 31. doi: 10.1097/BRS.0000000000002082. [Epub ahead of print] PubMed PMID: 28146028.
7)
North American Spine Society Evidence-Based Clinical Guidelines Committee. Antibiotic Prophylaxis in Spine Surgery. Burr Ridge, IL: North American Spine Society (NASS); 2013
8) , 10)
Chahoud J, Kanafani Z, Kanj SS. Surgical site infections following spine surgery: Eliminating the controversies in the diagnosis. Front Med (Lausanne) 2014;1:7.
9) , 11)
Cassir N, De La Rosa S, Melot A, Touta A, Troude L, Loundou A, Richet H, Roche PH. Risk factors for surgical site infections after neurosurgery: A focus on the postoperative period. Am J Infect Control. 2015 Aug 20. pii: S0196-6553(15)00756-7. doi: 10.1016/j.ajic.2015.07.005. [Epub ahead of print] PubMed PMID: 26300100.
12)
Wathen C, Kshettry VR, Krishnaney A, Gordon SM, Fraser T, Benzel EC, Modic MT, Butler S, Machado AG. The Association Between Operating Room Personnel and Turnover With Surgical Site Infection in More Than 12 000 Neurosurgical Cases. Neurosurgery. 2016 Dec;79(6):889-894. PubMed PMID: 27465846.
13)
Radcliff KE, Neusner AD, Millhouse P, Harrop JD, Kepler CK, Rasouli MR, Albert TJ, Vaccaro AR. What's New in the Diagnosis and Prevention of Spine Surgical Site Infections. Spine J. 2014 Sep 25. pii: S1529-9430(14)01495-8. doi: 10.1016/j.spinee.2014.09.022. [Epub ahead of print] Review. PubMed PMID: 25264181.
14)
Sundseth J, Sundseth A, Berg-Johnsen J, Sorteberg W, Lindegaard KF. Cranioplasty with autologous cryopreserved bone after decompressive craniectomy. Complications and risk factors for developing surgical site infection. Acta Neurochir (Wien). 2014 Feb 4. [Epub ahead of print] PubMed PMID: 24493001
15)
Dimovska-Gavrilovska A, Chaparoski A, Gavrilovski A, Milenkovikj Z. The Importance of Perioperative Prophylaxis with Cefuroxime or Ceftriaxone in the Surgical Site Infections Prevention after Cranial and Spinal Neurosurgical Procedures. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2017 Sep 1;38(2):85-97. doi: 10.1515/prilozi-2017-0026. PubMed PMID: 28991759.
16)
Malis LI: Prevention of neurosurgical infection by intraoperative antibiotics. Neurosurgery 5:339-343, 1979
17)
Barker FG 2nd: Efficacy of prophylactic antibiotics for craniotomy: A meta-analysis. Neurosurgery 35:484-490, 1994
18)
Barker FG 2nd: Efficacy of prophylactic antibiotic therapy in spinal surgery: A meta-analysis. Neurosurgery 51:391-401, 2002
19)
Bullock R, van Dellen JR, Ketelby W, Reinach SG: A double- blind placebo controlled trial of perioperative prophylactic antibiotics for elective neurosurgery. J Neurosurg 69:687-691, 1988
20)
Ingham HR, Kalbag RM, Sisson PR, Allcutt DA, Betty MJ, Crawford PJ, Gillham NR, Hankinson J, Sengupta RP, Strong AJ, Sinar EJ, Crone PB, Gillham M, Gould FK, Hudson SJ, Wardle JK, Cartmill TDI, Strokes ER: Simple perioperative antimicrobial chemoprophylaxis in elective neurosurgical procedures. J Hosp Infect 12: 225-233, 1988
23)
Tanner, J; Parkinson, H (2002). “Double gloving to reduce surgical cross-infection”. The Cochrane Library (3): CD003087. doi:10.1002/14651858.CD003087. PMID 12137673.
24)
Tanner, J; Parkinson, H (2006). “Double gloving to reduce surgical cross-infection”. The Cochrane Library (3): CD003087. doi:10.1002/14651858.CD003087.pub2
25)
Martin JR, Adogwa O, Brown CR, Bagley CA, Richardson WJ, Lad SP, Kuchibhatla M, Gottfried ON. Experience with intrawound vancomycin powder for spinal deformity surgery. Spine (Phila Pa 1976). 2014 Jan 15;39(2):177-84. doi: 10.1097/BRS.0000000000000071. PubMed PMID: 24158179.
26)
Kawabata A, Sakai K, Sato H, Sasaki S, Torigoe I, Tomori M, Yuasa M, Matsukura Y, Arai Y. Methicillin-resistant Staphylococcus Aureus Nasal Swab and Suction Drain Tip Cultures in 4573 Spinal Surgeries: Efficacy in Management of Surgical Site Infections. Spine (Phila Pa 1976). 2017 Aug 1. doi: 10.1097/BRS.0000000000002360. [Epub ahead of print] PubMed PMID: 28767628.
27)
López Pereira P, Díaz-Agero Pérez C, López Fresneña N, Las Heras Mosteiro J, Palancar Cabrera A, Rincón Carlavilla ÁL, Aranaz Andrés JM. 'Epidemiology of surgical site infection in a neurosurgery department'. Br J Neurosurg. 2016 Dec 1:1-6. [Epub ahead of print] PubMed PMID: 27905216.
28)
Klemencsics I, Lazary A, Szoverfi Z, Bozsodi A, Eltes P, Varga PP. Risk factors for surgical site infection in elective routine degenerative lumbar surgeries. Spine J. 2016 Aug 9. pii: S1529-9430(16)30869-5. doi: 10.1016/j.spinee.2016.08.018. [Epub ahead of print] PubMed PMID: 27520077.
29)
Puvanesarajah V, Hassanzadeh H. The True Cost of a Dural Tear: Medical and Economic Ramifications of Incidental Durotomy During Lumbar Discectomy in Elderly Medicare Beneficiaries. Spine (Phila Pa 1976). 2016 Aug 31. [Epub ahead of print] PubMed PMID: 27584677.
30)
Atkinson RA, Stephenson J, Jones A, Ousey KJ. An assessment of key risk factors for surgical site infection in patients undergoing surgery for spinal metastases. J Wound Care. 2016 Sep;25 Suppl 9:S30-4. doi: 10.12968/jowc.2016.25.Sup9.S30. PubMed PMID: 27608739.
31)
Selby LV, Sjoberg DD, Cassella D, Sovel M, Weiser MR, Sepkowitz K, Jones DR, Strong VE. Comparing surgical infections in National Surgical Quality Improvement Project and an Institutional Database. J Surg Res. 2015 Jun 15;196(2):416-20. doi: 10.1016/j.jss.2015.02.072. Epub 2015 Mar 6. PubMed PMID: 25840487; PubMed Central PMCID: PMC4667735.
32)
Liu J, Ma L, You C. Analysis of scalp wound infections among craniocerebral trauma patients following the 2008 wenchuan earthquake. Turk Neurosurg. 2012;22(1):27-31. doi: 10.5137/1019-5149.JTN.4391-11.0. PubMed PMID: 22274967.
surgical_site_infection.txt · Last modified: 2017/10/28 14:48 by administrador