Time of flight angiography (TOF) is an MRI technique to visualize flow within vessels, without the need to administer contrast. It is based on the phenomenon of flow-related enhancement of spins entering into an imaging slice. As a result of being unsaturated, these spins give more signal that surrounding stationary spins.
With 2-D TOF, multiple thin imaging slices are acquired with a flow-compensated gradient-echo sequence. These images can be combined by using a technique of reconstruction such as maximum intensity projection (MIP), to obtain a 3-D image of the vessels analogous to conventional angiography.
With 3-D TOF, a volume of images is obtained simultaneously by phase-encoding in the slice-select direction. An angiographic appearance can be generated using MIP, as is done with 2-D TOF.
This non-invasive technique is now widely considered equivalent to the gold standard, digital subtraction angiography for some applications such as follow-up of coiled cerebral aneurysms 4) 5) 6) 7) 8).
TOF MRA seemed to be reliable in screening for aneurysm recurrence after coil embolization with Enterprise stent assistance, especially in the evaluation of the source images (SI), in addition to maximal intensity projection (MIP) images in the TOF MRA 9).
High spatial resolution time-of-flight MR angiography can be recommended for preoperative imaging of lenticulostriate arteries to plan the extent of neurosurgical resection in patients with glial tumors of the insular lobe 10).