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Tyrosine kinase

Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. The proteins are activated by adding a phosphate group to the protein (phosphorylation). TKIs are typically used as anti-cancer drugs.

Tyrosine kinase signaling through the vascular endothelial growth factor receptor 2 (VEGFR2), platelet derived growth factor receptor- α (PDGFR-α) and KIT cell surface receptors mediates neo-angiogenesis and contributes to cancer cell survival in recurrent anaplastic and low-grade glioma.

see Tyrosine kinase inhibitor.

see Tyrosine kinase receptor

tyrosine_kinase.txt · Last modified: 2018/02/07 08:23 by administrador