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WHO grade 2 glioma

Pilomyxoid astrocytoma 9425/3* - WHO grade II

Pleomorphic xanthoastrocytoma 9424/3 - WHO grade II

Diffuse astrocytoma 9400/3 - WHO grade II

Fibrillary astrocytoma 9420/3

Protoplasmic astrocytoma 9410/3

Gemistocytic astrocytoma 9411/3

Martino et al. reviewed a consecutive series of 19 patients with GIIG within functional areas who underwent two operations separated by at least 1 year. Intraoperative electrical stimulation mapping was used in all operations for recurrence and in 14 of the initial procedures. A specific rehabilitation was provided. FINDINGS: At the first operation, we performed 14 subtotal and 5 partial resections. Eighteen patients returned to a normal socio-professional life. Nine patients received adjuvant treatment. At the second operation, we performed 1 total, 13 subtotal and 5 partial resections. Three patients with a preoperative neurological deficit improved, 13 remained unchanged, and 3 slight new deficits appeared. In 14 of the 17 patients with preoperative chronic epilepsy, the seizures were reduced or disappeared. Sixteen patients returned to a normal socio-professional life. Pathohistological examination showed that 11 tumours had progressed to high-grade glioma. The median time between the two operations was 4.1 years (range 1 to 7.8 years) and the median follow-up from initial diagnosis was 6.6 years (range 2.3 to 14.3 years). No deaths occurred during the follow-up period. CONCLUSIONS: Repeat operations guided by intra-operative electrical stimulation is an efficacious treatment for recurrent grade II glioma in an eloquent area 1).

Martino J, Taillandier L, Moritz-Gasser S, Gatignol P, Duffau H. Re-operation is a safe and effective therapeutic strategy in recurrent WHO grade II gliomas within eloquent areas. Acta Neurochir (Wien). 2009 May;151(5):427-36; discussion 436. doi: 10.1007/s00701-009-0232-6. PubMed PMID: 19337688.
who_grade_2_glioma.txt · Last modified: 2017/03/02 23:39 by administrador