Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) in 2014 Since 2005, state-of-the-art therapy in glioblastoma multiforme consists of maximal safe resection followed by combined radiotherapy and chemotherapy with temozolomide, according to Stupp regimen 1). 2) , particularly in patients that demonstrate MGMT promoter methylation. At recurrence there is no consensus as to the standard of care as no therapeutic options have produced substantial survival benefit 3).
In the early 1990's, endovascular treatment using embolic coils for the treatment of intracranial aneurysms was established. Since then, there has been a significant body of peer-reviewed literature written by medical experts regarding the use, safety, and efficacy of these detachable embolic coils. With the publishing of the ISAT (Intracranial Subarachnoid Aneurysm Trial) trial data in 2005, which compared clinical outcomes of neurosurgical clipping and endovascular coiling, embolic coiling became the preferred method for treatment of the majority of unruptured intracranial aneurysms 4).
Juha Hernesniemi, published the lateral supraorbital craniotomy 5) it avoids the approach through the sylvian fissure (SF) and irrespective of the SF anatomy approaches the aneurysms immediately subfrontally. The SF is only partially open.
The H index was suggested in 2005 by Jorge E. Hirsch, a physicist at UCSD, as a tool for determining theoretical physicists' relative quality and is sometimes called the Hirsch index or Hirsch number.
Since its introduction in 1991, the Marshall CT classification has become largely accepted for its descriptive and predictive value. For example, the IMPACT (International Mission for Prognosis and Analysis of Clinical Trial in TBI) prognostic model applies the Marshall CT score for 6-month outcome prediction in patients with moderate to severe TBI 6).
WANS is a non-profit public benefit association and is established in October 2005 as an honor society to promote cooperation and camaraderie amongst world leaders of neurosurgery, exchange of scientific knowledge and recognition of major contributors to the specialty.