In 2016, Li et al. introduced the use of FLAIR sequences to demonstrate the association of EOR with survival and found that additional resection of the peri-enhancement area could prolong the survival of patients with GBM 1).
Ducis et al pointed out in their 2016 study, only 8.9% of neurosurgical studies were regarded as being high-quality evidence with wide variability existing between subspecialty. Additionally, less than 25% of all guidelines they considered were offered with the highest degree of confidence (Class I) 2).
Since 2016, 35 of 50 U.S. states have passed opioid-limiting laws