4'-O-β-D-Glucosyl-5-O-Methylvisammino could exert neuroprotection by inhibiting the P13D/Akt protein, attenuating inflammation, and cleaved caspase 3- and -9a-related apoptosis. This study also lends credence to support the notion that the prevention of OGOMV could attenuate proinflammatory cytokine mRNA and late-onset caspases in tMCAO and merits further study 1).

Chang CZ, Wu SC. 4'-O-β-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats. World Neurosurg. 2016 May;89:474-88. doi: 10.1016/j.wneu.2016.01.061. Epub 2016 Feb 8. PubMed PMID: 26868427.
  • 4_-o-β-d-glucosyl-5-o-methylvisamminol.txt
  • Last modified: 2016/05/31 16:25
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