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Abaloparatide for osteoporosis

Abaloparatide increases bone formation for treating established osteoporosis.

Initial treatment with abaloparatide may result in greater vertebral fracture reduction compared with alendronate in postmenopausal women with osteoporosis 1). Have not yet been studied in the chronic glucocorticoid population 2).


Last update nov 30 2019

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8: Leder BZ, Zapalowski C, Hu MY, Hattersley G, Lane NE, Singer AJ, Dore RK. Fracture and Bone Mineral Density Response by Baseline Risk in Patients Treated With Abaloparatide Followed by Alendronate: Results From the Phase 3 ACTIVExtend Trial. J Bone Miner Res. 2019 Aug 14. doi: 10.1002/jbmr.3848. [Epub ahead of print] PubMed PMID: 31411768.

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13: McGreevy JL, Kane MP, Busch RS, Bakst G, ElDeiry S. A pharmacist-run anabolic osteoporosis clinic: An abaloparatide descriptive report. J Am Pharm Assoc (2003). 2019 Jul - Aug;59(4):593-597. doi: 10.1016/j.japh.2019.03.017. Epub 2019 May 14. PubMed PMID: 31101442.

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15: Ning Z, Tan B, Chen B, Lau DSA, Wong TM, Sun T, Peng S, Li Z, Lu WW. Precisely Controlled Delivery of Abaloparatide through Injectable Hydrogel to Promote Bone Regeneration. Macromol Biosci. 2019 Jun;19(6):e1900020. doi: 10.1002/mabi.201900020. Epub 2019 May 8. PubMed PMID: 31066995.

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18: Chandler H, Brooks DJ, Hattersley G, Bouxsein ML, Lanske B. Abaloparatide increases bone mineral density and bone strength in ovariectomized rabbits with glucocorticoid-induced osteopenia. Osteoporos Int. 2019 Aug;30(8):1607-1616. doi: 10.1007/s00198-019-04999-4. Epub 2019 May 3. PubMed PMID: 31053927; PubMed Central PMCID: PMC6663928.

19: Besschetnova T, Brooks DJ, Hu D, Nagano K, Nustad J, Ominsky M, Mitlak B, Hattersley G, Bouxsein ML, Baron R, Lanske B. Abaloparatide improves cortical geometry and trabecular microarchitecture and increases vertebral and femoral neck strength in a rat model of male osteoporosis. Bone. 2019 Jul;124:148-157. doi: 10.1016/j.bone.2019.04.025. Epub 2019 Apr 30. PubMed PMID: 31051317.

20: Tan X, Wen F, Yang W, Xie JY, Ding LL, Mo YX. Comparative efficacy and safety of pharmacological interventions for osteoporosis in postmenopausal women: a network meta-analysis (Chongqing, China). Menopause. 2019 Aug;26(8):929-939. doi: 10.1097/GME.0000000000001321. PubMed PMID: 31021904.

21: Yang L, Kang N, Yang JC, Su QJ, Liu YZ, Guan L, Liu T, Meng XL, Wang Y, Hai Y. Drug efficacies on bone mineral density and fracture rate for the treatment of postmenopausal osteoporosis: a network meta-analysis. Eur Rev Med Pharmacol Sci. 2019 Mar;23(6):2640-2668. doi: 10.26355/eurrev_201903_17414. PubMed PMID: 30964193.

22: Fontalis A, Kenanidis E, Kotronias RA, Papachristou A, Anagnostis P, Potoupnis M, Tsiridis E. Current and emerging osteoporosis pharmacotherapy for women: state of the art therapies for preventing bone loss. Expert Opin Pharmacother. 2019 Jun;20(9):1123-1134. doi: 10.1080/14656566.2019.1594772. Epub 2019 Apr 8. Review. PubMed PMID: 30958709.

23: Costa S, Fairfield H, Reagan MR. Inverse correlation between trabecular bone volume and bone marrow adipose tissue in rats treated with osteoanabolic agents. Bone. 2019 Jun;123:211-223. doi: 10.1016/j.bone.2019.03.038. Epub 2019 Apr 4. PubMed PMID: 30954729; PubMed Central PMCID: PMC6559822.

24: Reginster J-, Bianic F, Campbell R, Martin M, Williams SA, Fitzpatrick LA. Abaloparatide for risk reduction of nonvertebral and vertebral fractures in postmenopausal women with osteoporosis: a network meta-analysis. Osteoporos Int. 2019 Jul;30(7):1465-1473. doi: 10.1007/s00198-019-04947-2. Epub 2019 Apr 6. PubMed PMID: 30953114; PubMed Central PMCID: PMC6614166.

25: Barrionuevo P, Kapoor E, Asi N, Alahdab F, Mohammed K, Benkhadra K, Almasri J, Farah W, Sarigianni M, Muthusamy K, Al Nofal A, Haydour Q, Wang Z, Murad MH. Efficacy of Pharmacological Therapies for the Prevention of Fractures in Postmenopausal Women: A Network Meta-Analysis. J Clin Endocrinol Metab. 2019 May 1;104(5):1623-1630. doi: 10.1210/jc.2019-00192. PubMed PMID: 30907957.

26: Watts NB, Hattersley G, Fitzpatrick LA, Wang Y, Williams GC, Miller PD, Cosman F. Abaloparatide effect on forearm bone mineral density and wrist fracture risk in postmenopausal women with osteoporosis. Osteoporos Int. 2019 Jun;30(6):1187-1194. doi: 10.1007/s00198-019-04890-2. Epub 2019 Mar 21. PubMed PMID: 30899994; PubMed Central PMCID: PMC6546661.

27: Merlotti D, Falchetti A, Chiodini I, Gennari L. Efficacy and safety of abaloparatide for the treatment of post-menopausal osteoporosis. Expert Opin Pharmacother. 2019 May;20(7):805-811. doi: 10.1080/14656566.2019.1583208. Epub 2019 Mar 11. Review. PubMed PMID: 30856013.

28: Lanske B, Chandler H, Pierce A, Brown J, Ominsky M, Kostenuik P, Hattersley G. Abaloparatide, a PTH receptor agonist with homology to PTHrP, enhances callus bridging and biomechanical properties in rats with femoral fracture. J Orthop Res. 2019 Apr;37(4):812-820. doi: 10.1002/jor.24254. Epub 2019 Mar 21. PubMed PMID: 30790359.

29: Simmons BF 3rd, Caprio AJ. Abaloparatide (Tymlos) for Osteoporosis. Am Fam Physician. 2019 Feb 15;99(4):260-261. PubMed PMID: 30763045.

30: Hiligsmann M, Williams SA, Fitzpatrick LA, Silverman SS, Weiss R, Reginster JY. Cost-effectiveness of sequential treatment with abaloparatide vs. teriparatide for United States women at increased risk of fracture. Semin Arthritis Rheum. 2019 Oct;49(2):184-196. doi: 10.1016/j.semarthrit.2019.01.006. Epub 2019 Jan 10. PubMed PMID: 30737062.

31: Hills JM, Khan I, Archer KR, Sivaganesan A, Daryoush J, Hong DY, Dahir KM, Devin CJ, Stephens B. Metabolic and Endocrine Disorders in Pseudarthrosis. Clin Spine Surg. 2019 Jun;32(5):E252-E257. doi: 10.1097/BSD.0000000000000788. PubMed PMID: 30730424.

32: McCloskey EV, Fitzpatrick LA, Hu MY, Williams G, Kanis JA. Effect of abaloparatide on vertebral, nonvertebral, major osteoporotic, and clinical fractures in a subset of postmenopausal women at increased risk of fracture by FRAX probability. Arch Osteoporos. 2019 Feb 5;14(1):15. doi: 10.1007/s11657-019-0564-7. PubMed PMID: 30719589; PubMed Central PMCID: PMC6373333.

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34: Sleeman A, Clements JN. Abaloparatide: A new pharmacological option for osteoporosis. Am J Health Syst Pharm. 2019 Jan 25;76(3):130-135. doi: 10.1093/ajhp/zxy022. Review. PubMed PMID: 30689744.

35: Yang Y, Lei H, Wang B. Effect of the PTHrP(1-34) analog abaloparatide on inducing chondrogenesis involves inhibition of intracellular reactive oxygen species production. Biochem Biophys Res Commun. 2019 Feb 19;509(4):960-965. doi: 10.1016/j.bbrc.2019.01.049. Epub 2019 Jan 14. PubMed PMID: 30654932.

36: Eastell R, Mitlak BH, Wang Y, Hu M, Fitzpatrick LA, Black DM. Bone turnover markers to explain changes in lumbar spine BMD with abaloparatide and teriparatide: results from ACTIVE. Osteoporos Int. 2019 Mar;30(3):667-673. doi: 10.1007/s00198-018-04819-1. Epub 2019 Jan 11. PubMed PMID: 30635696; PubMed Central PMCID: PMC6422956.

37: Anagnostis P, Gkekas NK, Potoupnis M, Kenanidis E, Tsiridis E, Goulis DG. New therapeutic targets for osteoporosis. Maturitas. 2019 Feb;120:1-6. doi: 10.1016/j.maturitas.2018.11.010. Epub 2018 Nov 16. Review. PubMed PMID: 30583758.

38: Ehrenmann J, Schöppe J, Klenk C, Rappas M, Kummer L, Doré AS, Plückthun A. High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist. Nat Struct Mol Biol. 2018 Dec;25(12):1086-1092. doi: 10.1038/s41594-018-0151-4. Epub 2018 Nov 19. PubMed PMID: 30455434.

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40: Rachner TD, Hofbauer LC, Göbel A, Tsourdi E. Novel therapies in osteoporosis: PTH-related peptide analogs and inhibitors of sclerostin. J Mol Endocrinol. 2019 Feb 1;62(2):R145-R154. doi: 10.1530/JME-18-0173. Review. PubMed PMID: 30389901.

41: Ricarte FR, Le Henaff C, Kolupaeva VG, Gardella TJ, Partridge NC. Parathyroid hormone(1-34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A-CRTC3 signaling. J Biol Chem. 2018 Dec 28;293(52):20200-20213. doi: 10.1074/jbc.RA118.004751. Epub 2018 Oct 30. PubMed PMID: 30377251; PubMed Central PMCID: PMC6311504.

42: Miller PD, Hattersley G, Lau E, Fitzpatrick LA, Harris AG, Williams GC, Hu MY, Riis BJ, Russo L, Christiansen C. Bone mineral density response rates are greater in patients treated with abaloparatide compared with those treated with placebo or teriparatide: Results from the ACTIVE phase 3 trial. Bone. 2019 Mar;120:137-140. doi: 10.1016/j.bone.2018.10.015. Epub 2018 Oct 22. PubMed PMID: 30359763.

43: Chandler H, Lanske B, Varela A, Guillot M, Boyer M, Brown J, Pierce A, Ominsky M, Mitlak B, Baron R, Kostenuik P, Hattersley G. Abaloparatide, a novel osteoanabolic PTHrP analog, increases cortical and trabecular bone mass and architecture in orchiectomized rats by increasing bone formation without increasing bone resorption. Bone. 2019 Mar;120:148-155. doi: 10.1016/j.bone.2018.10.012. Epub 2018 Oct 19. PubMed PMID: 30343166.

44: Bernhardsson M, Aspenberg P. Abaloparatide versus teriparatide: a head to head comparison of effects on fracture healing in mouse models. Acta Orthop. 2018 Dec;89(6):674-677. doi: 10.1080/17453674.2018.1523771. Epub 2018 Oct 18. PubMed PMID: 30334479; PubMed Central PMCID: PMC6300720.

45: Langdahl BL, Andersen JD. Treatment of Osteoporosis: Unmet Needs and Emerging Solutions. J Bone Metab. 2018 Aug;25(3):133-140. doi: 10.11005/jbm.2018.25.3.133. Epub 2018 Aug 31. Review. PubMed PMID: 30237992; PubMed Central PMCID: PMC6135648.

46: Ramchand SK, Seeman E. Advances and Unmet Needs in the Therapeutics of Bone Fragility. Front Endocrinol (Lausanne). 2018 Sep 6;9:505. doi: 10.3389/fendo.2018.00505. eCollection 2018. Review. PubMed PMID: 30237785; PubMed Central PMCID: PMC6135909.

47: Tabacco G, Bilezikian JP. Osteoanabolic and dual action drugs. Br J Clin Pharmacol. 2019 Jun;85(6):1084-1094. doi: 10.1111/bcp.13766. Epub 2019 Apr 3. Review. PubMed PMID: 30218587; PubMed Central PMCID: PMC6533433.

48: Le QA, Hay JW, Becker R, Wang Y. Cost-effectiveness Analysis of Sequential Treatment of Abaloparatide Followed by Alendronate Versus Teriparatide Followed by Alendronate in Postmenopausal Women With Osteoporosis in the United States. Ann Pharmacother. 2019 Feb;53(2):134-143. doi: 10.1177/1060028018798034. Epub 2018 Aug 30. PubMed PMID: 30160186; PubMed Central PMCID: PMC6311620.

49: Haas AV, LeBoff MS. Osteoanabolic Agents for Osteoporosis. J Endocr Soc. 2018 Jul 9;2(8):922-932. doi: 10.1210/js.2018-00118. eCollection 2018 Aug 1. Review. PubMed PMID: 30087947; PubMed Central PMCID: PMC6065487.

50: Reginster JY, Hattersley G, Williams GC, Hu MY, Fitzpatrick LA, Lewiecki EM. Abaloparatide is an Effective Treatment Option for Postmenopausal Osteoporosis: Review of the Number Needed to Treat Compared with Teriparatide. Calcif Tissue Int. 2018 Nov;103(5):540-545. doi: 10.1007/s00223-018-0450-0. Epub 2018 Jun 27. PubMed PMID: 29951742; PubMed Central PMCID: PMC6182596.

51: Pietrogrande L, Raimondo E. Abaloparatide for the treatment of postmenopausal osteoporosis. Drugs Today (Barc). 2018 May;54(5):293-303. doi: 10.1358/dot.2018.54.5.2800621. Review. PubMed PMID: 29911694.

52: Wolverton D, Elliott DP. Evaluating the Evidence Behind Treating Osteoporosis in the Oldest Adults. Consult Pharm. 2018 Jun 1;33(6):308-316. doi: 10.4140/TCP.n.2018.308. Review. PubMed PMID: 29880092.

53: Choksi P, Jepsen KJ, Clines GA. The challenges of diagnosing osteoporosis and the limitations of currently available tools. Clin Diabetes Endocrinol. 2018 May 29;4:12. doi: 10.1186/s40842-018-0062-7. eCollection 2018. Review. PubMed PMID: 29862042; PubMed Central PMCID: PMC5975657.

54: Bone HG, Cosman F, Miller PD, Williams GC, Hattersley G, Hu MY, Fitzpatrick LA, Mitlak B, Papapoulos S, Rizzoli R, Dore RK, Bilezikian JP, Saag KG. ACTIVExtend: 24 Months of Alendronate After 18 Months of Abaloparatide or Placebo for Postmenopausal Osteoporosis. J Clin Endocrinol Metab. 2018 Aug 1;103(8):2949-2957. doi: 10.1210/jc.2018-00163. PubMed PMID: 29800372; PubMed Central PMCID: PMC6097601.

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56: Makino A, Takagi H, Takahashi Y, Hase N, Sugiyama H, Yamana K, Kobayashi T. Abaloparatide Exerts Bone Anabolic Effects with Less Stimulation of Bone Resorption-Related Factors: A Comparison with Teriparatide. Calcif Tissue Int. 2018 Sep;103(3):289-297. doi: 10.1007/s00223-018-0422-4. Epub 2018 May 3. PubMed PMID: 29725706; PubMed Central PMCID: PMC6105163.

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60: Cosman F. Long-term treatment strategies for postmenopausal osteoporosis. Curr Opin Rheumatol. 2018 Jul;30(4):420-426. doi: 10.1097/BOR.0000000000000509. Review. PubMed PMID: 29621030.

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62: McClung MR, Harvey NC, Fitzpatrick LA, Miller PD, Hattersley G, Wang Y, Cosman F. Effects of abaloparatide on bone mineral density and risk of fracture in postmenopausal women aged 80 years or older with osteoporosis. Menopause. 2018 Jul;25(7):767-771. doi: 10.1097/GME.0000000000001080. PubMed PMID: 29462094; PubMed Central PMCID: PMC6015760.

63: McClung MR, Williams GC, Hattersley G, Fitzpatrick LA, Wang Y, Miller PD. Correction to: Geography of Fracture Incidence in Postmenopausal Women with Osteoporosis Treated with Abaloparatide. Calcif Tissue Int. 2018 Jun;102(6):634. doi: 10.1007/s00223-018-0390-8. PubMed PMID: 29383409; PubMed Central PMCID: PMC6828013.

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68: Reginster JY, Al Daghri N, Kaufman JM, Bruyère O. Effect of a sequential treatment combining abaloparatide and alendronate for the management of postmenopausal osteoporosis. Expert Opin Pharmacother. 2018 Feb;19(2):159-161. doi: 10.1080/14656566.2017.1418857. Epub 2017 Dec 22. PubMed PMID: 29251010.

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70: Bilezikian JP, Hattersley G, Fitzpatrick LA, Harris AG, Shevroja E, Banks K, Leder BZ, Zanchetta JR, Hans D. Abaloparatide-SC improves trabecular microarchitecture as assessed by trabecular bone score (TBS): a 24-week randomized clinical trial. Osteoporos Int. 2018 Feb;29(2):323-328. doi: 10.1007/s00198-017-4304-9. Epub 2017 Nov 22. PubMed PMID: 29167971; PubMed Central PMCID: PMC5818587.

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abaloparatide_for_osteoporosis.txt · Last modified: 2019/11/30 13:17 by administrador