Dactinomycin, also known as actinomycin D, is a chemotherapy medication used to treat a number of types of cancer.
This includes Wilms tumor, rhabdomyosarcoma, Ewing's sarcoma, trophoblastic neoplasm, testicular cancer, and certain types of ovarian cancer. It is given by injection into a vein.
Most people develop side effects.
Common side effects include bone marrow suppression, vomiting, mouth ulcers, hair loss, liver problems, infections, and muscle pains.
Other serious side effects include future cancers, allergic reactions, and tissue death at the site of injection.
Use in pregnancy may harm the baby.
Dactinomycin is in the cytotoxic antibiotic family of medications.
It is believed to work by blocking the creation of RNA.
Dactinomycin was approved for medical use in the United States in 1964. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.
The wholesale cost in the developing world is about 24.73 USD per 500 mcg vial.
It is produced from bacteria Streptomyces parvullus.