Actinomycosis is an unusual chronic infection caused by a group of anaerobic Gram-positive bacilli from the Actinomyces genus. Actinomyces israelii is the mainly microorganism involved in human diseases, while Actinomyces meyeri, in dissimilarity to other species of Actinomyces, is a rare cause of human actinomycosis. A. meyeri regularly causes pulmonary disease, but instead there are few cases of empyema, displaying a predisposition for dissemination to distant organs. A. meyeri respiratory infection grants nonspecific symptoms or radiological characteristic findings. Consequently, microbiological and histological examinations are imperative for diagnosis.