Drug info: Acyclovir (Zovirax®) ℞ Adult: 30 mg/kg/day, in divided q 8 hr doses in minimum volume of 100 ml IV fluid over 1 hr (cau- tion: this fluid load may be hazardous, especially since cerebral edema is already usually problematic) for 14–21 days (some relapses have been reported after only 10 days of treatment).
℞ Children>6 mos age: 500mg/m2 IV q 8 hrs×10 days. ℞ Neonatal: 10 mg/kg IV q 8 hrs for 10 days.
Should be performed within ≤48 hrs of starting acyclovir (otherwise false negatives may occur).
Aciclovir (ACV), also known as acyclovir and acycloguanosine, is an antiviral medication.
It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include the prevention of cytomegalovirus infections following transplant and infections due to Epstein-Barr virus. It is available by mouth and intravenously.
Common side effects include nausea and diarrhea. Potentially serious side effects include kidney problems and low platelets. Greater care is recommended in those with poor liver or kidney function.
It is generally considered safe for use in pregnancy with no harms having been observed.
It is safe during breastfeeding.
Aciclovir is a nucleic acid analogue made from guanosine. It works by decreasing the making of the virus's DNA.
The discovery of aciclovir was announced in 1977.
It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.
It is available as a generic medication and is marketed under many brand names worldwide.
There is a case report of Multifocal varicella-zoster leukoencephalitis treated with IV acyclovir 1).