Alpha 2 macroglobulin

Is elevated in nephrotic syndrome, diabetes, severe burns, and other conditions, while a deficiency is associated with chronic obstructive pulmonary disease.

LRP1 bound A2M found to be associated with an inhibition of tumor cell proliferation, migration, invasion, spheroid formation, and anchorage-independent growth. Transcriptional studies implicated effects on the Wnt/beta-catenin signaling pathway. Notably, LRP1 antibodies could phenocopy the effects of A2M*. Our findings suggest a pathway of tumor suppression in astrocytoma that might be tractable to therapeutic exploitation 1).

Lindner I, Hemdan NY, Buchold M, Huse K, Bigl M, Oerlecke I, Ricken A, Gaunitz F, Sack U, Naumann A, Hollborn M, Thal D, Gebhardt R, Birkenmeier G. Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling. Cancer Res. 2010 Jan 1;70(1):277-87. doi: 10.1158/0008-5472.CAN-09-1462. Erratum in: Cancer Res. 2010 Mar 1;70(5):2140. PubMed PMID: 20048078.
  • alpha_2_macroglobulin.txt
  • Last modified: 2018/02/05 11:00
  • by administrador