Anaplastic large cell lymphoma (ALCL) , one of the malignant non Hodgkin lymphomas (NHL), typically associated with anaplastic lymphoma kinase (ALK) expression. Some cases lack ALK translocation correlated with a more unfavorable prognosis.
A case of ALCL-ALK(-) that presented as a progressive, enlarged, swollen mass on the scalp after an acute head injury in an 84-year-old man. Neither palpable lymph nodes nor any B symptoms were noted at admission. Brain computed tomography showed a hematoma in the right posterior occipital region of the scalp as the only remarkable finding. Debridement and biopsy were performed. Histologic and immunohistochemical analysis of the specimen revealed an ALCL-ALK(-) of the scalp. The lymphoma was resistant to bendamustine-containing chemotherapies, ultimately leading to the patient's death within 2 months.
This case report highlights the importance of recognizing the possibility of an ALCL presenting as a focal inflammatory swelling mass on the scalp 2).