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Apoptosis inducing factor

Apoptosis inducing factor (AIF) is a family of mitochondrial oxidoreductases that play important roles in mitochondrial metabolism and redox control. AIF-1 has been demonstrated to exert cell-killing effect via apoptosis in cancer cells, whereas the role of AIF-2 in cancer cells has not been determined.

A study of Chen et al., aimed to investigate the role of AIF-2 in human glioma cells. They found that AIF-2 was upregulated in human glioma tissues and cell lines, especially in U251 cells. Downregulation of AIF-2 using specific siRNA (Si-AIF-2) significantly reduced cell proliferation, induced G1 cell cycle arrest and differently regulated the expression of cell cycle regulator proteins in U251 cells. In addition, the results of Matrigel invasion assay and live-cell tracking assay showed that knockdown of AIF-2 inhibited cell invasion and migration. The results of immunocytochemistry indicated that knockdown of AIF-2 significantly attenuated the nuclear translocation of AIF-1, which was confirmed by western blot analysis. Furthermore, downregulation of AIF-2 resulted in mitochondrial dysfunction in U251 cells, as evidenced by reduced mitochondrial membrane potential (MMP), mitochondrial complex I activity, and mitochondrial Ca2+ buffering capacity.

In conclusion, they found that AIF-2 plays a key role in promoting cell proliferation, invasion, and migration via regulating AIF-1-related mitochondrial cascades. Downregulation of the candidate oncogene AIF-2 might constitute a strategy to kill human glioma cells 1).


1: Chen W, Liu H, Wang T, Bao G, Wang N, Li RC. Downregulation of AIF-2 Inhibits Proliferation, Migration, and Invasion of Human Glioma Cells via Mitochondrial Dysfunction. J Mol Neurosci. 2019 Apr 13. doi: 10.1007/s12031-019-01306-y. [Epub ahead of print] PubMed PMID: 30982162.

2: Li M, Sun S, Dangelmajer S, Zhang Q, Wang J, Hu F, Dong F, Kahlert UD, Zhu M, Lei T. Exploiting tumor-intrinsic signals to induce mesenchymal stem cell-mediated suicide gene therapy to fight malignant glioma. Stem Cell Res Ther. 2019 Mar 12;10(1):88. doi: 10.1186/s13287-019-1194-0. PubMed PMID: 30867058; PubMed Central PMCID: PMC6417183.

3: Li M, Zeng L, Liu S, Dangelmajer S, Kahlert UD, Huang H, Han Y, Chi X, Zhu M, Lei T. Transforming Growth Factor-β Promotes Homing and Therapeutic Efficacy of Human Mesenchymal Stem Cells to Glioblastoma. J Neuropathol Exp Neurol. 2019 Apr 1;78(4):315-325. doi: 10.1093/jnen/nlz016. PubMed PMID: 30863846.

4: Yang Y, Liang S, Li Y, Gao F, Cao Y, Zhao X, Gao G, Li L. Effects of early administration of insulin-like growth factor-1 on cognitive function in septic encephalopathy. Neuropsychiatr Dis Treat. 2019 Jan 23;15:323-337. doi: 10.2147/NDT.S190845. eCollection 2019. PubMed PMID: 30774344; PubMed Central PMCID: PMC6353230.

5: Cho HY, Thein TZ, Wang W, Swenson SD, Fayngor RA, Ou M, Marín-Ramos NI, Schönthal AH, Hofman FM, Chen TC. The Rolipram-Perillyl Alcohol Conjugate (NEO214) Is A Mediator of Cell Death through the Death Receptor Pathway. Mol Cancer Ther. 2019 Mar;18(3):517-530. doi: 10.1158/1535-7163.MCT-18-0465. Epub 2019 Jan 15. PubMed PMID: 30647121.

6: Chen CH, Chen PY, Lin YY, Feng LY, Chen SH, Chen CY, Huang YC, Huang CY, Jung SM, Chen LY, Wei KC. Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma. J Neurosurg. 2019 Jan 11:1-12. doi: 10.3171/2018.8.JNS181217. [Epub ahead of print] PubMed PMID: 30641835.

7: Mohebbi A, Ebrahimzadeh MS, Baghban Rahimi S, Saeidi M, Tabarraei A, Mohebbi SR, Shirian S, Gorji A, Ghaemi A. Non-replicating Newcastle Disease Virus as an adjuvant for DNA vaccine enhances antitumor efficacy through the induction of TRAIL and granzyme B expression. Virus Res. 2019 Feb;261:72-80. doi: 10.1016/j.virusres.2018.12.014. Epub 2018 Dec 29. PubMed PMID: 30599161.

8: Huang N, Zhang X, Jiang Y, Mei H, Zhang L, Zhang Q, Hu J, Chen B. Increased levels of serum pigment epithelium-derived factor aggravate proteinuria via induction of podocyte actin rearrangement. Int Urol Nephrol. 2019 Feb;51(2):359-367. doi: 10.1007/s11255-018-2026-3. Epub 2018 Dec 7. PubMed PMID: 30536192; PubMed Central PMCID: PMC6394770.

9: Golinelli G, Grisendi G, Prapa M, Bestagno M, Spano C, Rossignoli F, Bambi F, Sardi I, Cellini M, Horwitz EM, Feletti A, Pavesi G, Dominici M. Targeting GD2-positive glioblastoma by chimeric antigen receptor empowered mesenchymal progenitors. Cancer Gene Ther. 2018 Nov 22. doi: 10.1038/s41417-018-0062-x. [Epub ahead of print] PubMed PMID: 30464207.

10: Lu JH, Peng BY, Chang CC, Dubey NK, Lo WC, Cheng HC, Wang JR, Wei HJ, Deng WP. Tumor-Targeted Immunotherapy by Using Primary Adipose-Derived Stem Cells and an Antigen-Specific Protein Vaccine. Cancers (Basel). 2018 Nov 15;10(11). pii: E446. doi: 10.3390/cancers10110446. PubMed PMID: 30445793; PubMed Central PMCID: PMC6266266.

11: Wang R, Bao H, Zhang S, Li R, Chen L, Zhu Y. miR-186-5p Promotes Apoptosis by Targeting IGF-1 in SH-SY5Y OGD/R Model. Int J Biol Sci. 2018 Oct 19;14(13):1791-1799. doi: 10.7150/ijbs.25352. eCollection 2018. PubMed PMID: 30443183; PubMed Central PMCID: PMC6231212.

12: Choi SA, Lee C, Kwak PA, Park CK, Wang KC, Phi JH, Lee JY, Chong S, Kim SK. Histone deacetylase inhibitor panobinostat potentiates the anti-cancer effects of mesenchymal stem cell-based sTRAIL gene therapy against malignant glioma. Cancer Lett. 2019 Feb 1;442:161-169. doi: 10.1016/j.canlet.2018.10.012. Epub 2018 Oct 24. PubMed PMID: 30367915.

13: Tsai YR, Chang CF, Lai JH, Wu JC, Chen YH, Kang SJ, Hoffer BJ, Tweedie D, Luo W, Greig NH, Chiang YH, Chen KY. Pomalidomide Ameliorates H₂O₂-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects. Int J Mol Sci. 2018 Oct 19;19(10). pii: E3252. doi: 10.3390/ijms19103252. PubMed PMID: 30347766; PubMed Central PMCID: PMC6213994.

14: Lu J, Li Q, Cai L, Zhu Z, Guan J, Wang C, Xia J, Xia L, Wen M, Zheng W, Su Z, Wang C. RBM17 controls apoptosis and proliferation to promote Glioma progression. Biochem Biophys Res Commun. 2018 Oct 20;505(1):20-28. doi: 10.1016/j.bbrc.2018.09.056. Epub 2018 Sep 15. PubMed PMID: 30227940.

15: Xiao X, Wang W, Li Y, Yang D, Li X, Shen C, Liu Y, Ke X, Guo S, Guo Z. HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma. J Exp Clin Cancer Res. 2018 Aug 28;37(1):201. doi: 10.1186/s13046-018-0880-6. PubMed PMID: 30153855; PubMed Central PMCID: PMC6114771.

16: Xu ZF, Sun XK, Chen G, Han C, Wang F, Zhang YD. Oroxyloside inhibits human glioma progression by suppressing proliferation, metastasis and inducing apoptosis related pathways. Biomed Pharmacother. 2018 Jan;97:1564-1574. doi: 10.1016/j.biopha.2017.09.100. Epub 2017 Nov 24. PubMed PMID: 29793319.

17: Yu Z, Chen Y, Wang S, Li P, Zhou G, Yuan Y. Inhibition of NF-κB results in anti-glioma activity and reduces temozolomide-induced chemoresistance by down-regulating MGMT gene expression. Cancer Lett. 2018 Aug 1;428:77-89. doi: 10.1016/j.canlet.2018.04.033. Epub 2018 Apr 27. PubMed PMID: 29705182.

18: He Y, Meng H, Xu H, Fan L, Zhou Z, Xu B, Sun L, Gao Y. Regulation of Integrated Stress Response Sensitizes U87MG Glioblastoma Cells to Temozolomide Through the Mitochondrial Apoptosis Pathway. Anat Rec (Hoboken). 2018 Apr 26. doi: 10.1002/ar.23839. [Epub ahead of print] PubMed PMID: 29698579.

19: Cai X, Yang Y, Xia W, Kong H, Wang M, Fu W, Long M, Hu Y, Xu D. RIP2 promotes glioma cell growth by regulating TRAF3 and activating the NF‑κB and p38 signaling pathways. Oncol Rep. 2018 Jun;39(6):2915-2923. doi: 10.3892/or.2018.6397. Epub 2018 Apr 23. PubMed PMID: 29693188.

20: Liang SD, Ma LQ, Gao ZY, Zhuang YY, Zhao YZ. Granulocyte colony-stimulating factor improves neurological function and angiogenesis in intracerebral hemorrhage rats. Eur Rev Med Pharmacol Sci. 2018 Apr;22(7):2005-2014. doi: 10.26355/eurrev_201804_14729. PubMed PMID: 29687856.

21: Ma L, Niu W, Yang S, Tian J, Luan H, Cao M, Xi W, Tu W, Jia J, Lv J. Inhibition of mitochondrial permeability transition pore opening contributes to cannabinoid type 1 receptor agonist ACEA-induced neuroprotection. Neuropharmacology. 2018 Jun;135:211-222. doi: 10.1016/j.neuropharm.2018.03.024. Epub 2018 Mar 21. PubMed PMID: 29574098.

22: Cao YX, Wang ZQ, Kang JX, Liu K, Zhao CF, Guo YX, Jiao BH. miR-424 protects PC-12 cells from OGD-induced injury by negatively regulating MKP-1. Eur Rev Med Pharmacol Sci. 2018 Mar;22(5):1426-1436. doi: 10.26355/eurrev_201803_14490. PubMed PMID: 29565504.

23: Di H, Zhang X, Guo Y, Shi Y, Fang C, Yuan Y, Wang J, Shang C, Guo W, Li C. Silencing LDHA inhibits proliferation, induces apoptosis and increases chemosensitivity to temozolomide in glioma cells. Oncol Lett. 2018 Apr;15(4):5131-5136. doi: 10.3892/ol.2018.7932. Epub 2018 Feb 2. PubMed PMID: 29552147; PubMed Central PMCID: PMC5840669.

24: Meng C, Zhang J, Dang B, Li H, Shen H, Li X, Wang Z. PERK Pathway Activation Promotes Intracerebral Hemorrhage Induced Secondary Brain Injury by Inducing Neuronal Apoptosis Both in Vivo and in Vitro. Front Neurosci. 2018 Feb 28;12:111. doi: 10.3389/fnins.2018.00111. eCollection 2018. PubMed PMID: 29541018; PubMed Central PMCID: PMC5835756.

25: Zhang W, Xiong Z, Wei T, Li Q, Tan Y, Ling L, Feng X. Nuclear factor 90 promotes angiogenesis by regulating HIF-1α/VEGF-A expression through the PI3K/Akt signaling pathway in human cervical cancer. Cell Death Dis. 2018 Feb 15;9(3):276. doi: 10.1038/s41419-018-0334-2. PubMed PMID: 29449553; PubMed Central PMCID: PMC5833414.

26: Wang Z, Liu Z, Yu G, Nie X, Jia W, Liu RE, Xu R. Paeoniflorin Inhibits Migration and Invasion of Human Glioblastoma Cells via Suppression Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition. Neurochem Res. 2018 Mar;43(3):760-774. doi: 10.1007/s11064-018-2478-y. Epub 2018 Feb 8. PubMed PMID: 29423667; PubMed Central PMCID: PMC5842263.

27: Tanrikulu B, Ziyal I, Bayri Y. In Vitro Effects of Mesenchymal Stem Cells and Various Agents on Apoptosis of Glioblastoma Cells. Turk Neurosurg. 2019;29(1):26-32. doi: 10.5137/1019-5149.JTN.21827-17.2. PubMed PMID: 29384188.

28: Wang FZ, Dai XL, Liu HY. Molecular mechanisms underlying the α-tomatine-directed apoptosis in human malignant glioblastoma cell lines A172 and U-118 MG. Exp Ther Med. 2017 Dec;14(6):6183-6192. doi: 10.3892/etm.2017.5294. Epub 2017 Oct 12. PubMed PMID: 29250143; PubMed Central PMCID: PMC5729398.

29: Hung CM, Liu LC, Ho CT, Lin YC, Way TD. Pterostilbene Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors and Downregulation of Cell Survival Proteins in TRAIL-Resistance Triple Negative Breast Cancer Cells. J Agric Food Chem. 2017 Dec 27;65(51):11179-11191. doi: 10.1021/acs.jafc.7b02358. Epub 2017 Dec 15. PubMed PMID: 29164887.

30: Luan W, Qian Y, Ni X, Chanda TK, Xia Y, Wang J, Yan Y, Xu B. Polygonatum odoratum lectin promotes BECN1 expression and induces autophagy in malignant melanoma by regulation of miR1290. Onco Targets Ther. 2017 Sep 14;10:4569-4577. doi: 10.2147/OTT.S147406. eCollection 2017. PubMed PMID: 29066911; PubMed Central PMCID: PMC5604572.

31: Bhere D, Tamura K, Wakimoto H, Choi SH, Purow B, Debatisse J, Shah K. microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis. Neuro Oncol. 2018 Jan 22;20(2):215-224. doi: 10.1093/neuonc/nox138. PubMed PMID: 29016934; PubMed Central PMCID: PMC5777493.

32: Xu ZF, Sun XK, Lan Y, Han C, Zhang YD, Chen G. Linarin sensitizes tumor necrosis factor-related apoptosis (TRAIL)-induced ligand-triggered apoptosis in human glioma cells and in xenograft nude mice. Biomed Pharmacother. 2017 Nov;95:1607-1618. doi: 10.1016/j.biopha.2017.08.021. Epub 2017 Oct 6. PubMed PMID: 28950661.

33: Wang SS, Feng L, Hu BG, Lu YF, Wang WM, Guo W, Suen CW, Jiao BH, Pang JX, Fu WM, Zhang JF. miR-133a Promotes TRAIL Resistance in Glioblastoma via Suppressing Death Receptor 5 and Activating NF-κB Signaling. Mol Ther Nucleic Acids. 2017 Sep 15;8:482-492. doi: 10.1016/j.omtn.2017.07.015. Epub 2017 Aug 4. PubMed PMID: 28918048; PubMed Central PMCID: PMC5560119.

34: Phi JH, Choi SA, Kwak PA, Lee JY, Wang KC, Hwang DW, Kim SK. Panobinostat, a histone deacetylase inhibitor, suppresses leptomeningeal seeding in a medulloblastoma animal model. Oncotarget. 2017 May 24;8(34):56747-56757. doi: 10.18632/oncotarget.18132. eCollection 2017 Aug 22. PubMed PMID: 28915627; PubMed Central PMCID: PMC5593598.

35: Zhen ZG, Ren SH, Ji HM, Ma JH, Ding XM, Feng FQ, Chen SL, Zou P, Ren JR, Jia L. Linarin suppresses glioma through inhibition of NF-κB/p65 and up-regulating p53 expression in vitro and in vivo. Biomed Pharmacother. 2017 Nov;95:363-374. doi: 10.1016/j.biopha.2017.08.023. Epub 2017 Sep 12. PubMed PMID: 28858735.

36: Xie Y, Wanggou S, Liu Q, Li X, Liu J, Wu M. A brain-specific isoform of apoptosis-inducing factor 2 attenuates ischemia-induced oxidative stress in HT22 cells. Neurochem Int. 2018 Jan;112:179-186. doi: 10.1016/j.neuint.2017.07.006. Epub 2017 Jul 18. PubMed PMID: 28732772.

37: Zhu Y, Bassoff N, Reinshagen C, Bhere D, Nowicki MO, Lawler SE, Roux J, Shah K. Bi-specific molecule against EGFR and death receptors simultaneously targets proliferation and death pathways in tumors. Sci Rep. 2017 Jun 1;7(1):2602. doi: 10.1038/s41598-017-02483-9. PubMed PMID: 28572590; PubMed Central PMCID: PMC5454031.

38: Yang Z, Jiang B, Wang Y, Ni H, Zhang J, Xia J, Shi M, Hung LM, Ruan J, Mak TW, Li Q, Han J. 2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter. Cell Rep. 2017 May 30;19(9):1846-1857. doi: 10.1016/j.celrep.2017.05.012. PubMed PMID: 28564603.

39: Li J, Wang F, Wang G, Sun Y, Cai J, Liu X, Zhang J, Lu X, Li Y, Chen M, Chen L, Jiang C. Combination epidermal growth factor receptor variant III peptide-pulsed dendritic cell vaccine with miR-326 results in enhanced killing on EGFRvIII-positive cells. Oncotarget. 2017 Apr 18;8(16):26256-26268. doi: 10.18632/oncotarget.15445. PubMed PMID: 28412740; PubMed Central PMCID: PMC5432254.

40: Lee WS, Jung JH, Panchanathan R, Yun JW, Kim DH, Kim HJ, Kim GS, Ryu CH, Shin SC, Hong SC, Choi YH, Jung JM. Ursodeoxycholic Acid Induces Death Receptor-mediated Apoptosis in Prostate Cancer Cells. J Cancer Prev. 2017 Mar;22(1):16-21. doi: 10.15430/JCP.2017.22.1.16. Epub 2017 Mar 30. PubMed PMID: 28382282; PubMed Central PMCID: PMC5380185.

41: Tzeng SY, Wilson DR, Hansen SK, Quiñones-Hinojosa A, Green JJ. Polymeric nanoparticle-based delivery of TRAIL DNA for cancer-specific killing. Bioeng Transl Med. 2016 Jun;1(2):149-159. doi: 10.1002/btm2.10019. PubMed PMID: 28349127; PubMed Central PMCID: PMC5365091.

42: Gao C, Yu H, Yan C, Zhao W, Liu Y, Zhang D, Li J, Liu N. X-linked inhibitor of apoptosis inhibits apoptosis and preserves the blood-brain barrier after experimental subarachnoid hemorrhage. Sci Rep. 2017 Mar 22;7:44918. doi: 10.1038/srep44918. PubMed PMID: 28327595; PubMed Central PMCID: PMC5361183.

43: Zhao Y, Zhao J, Zhang M, Zhao Y, Li J, Ma X, Huang T, Pang H, Wang B, Song J. Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats. Mediators Inflamm. 2017;2017:1570917. doi: 10.1155/2017/1570917. Epub 2017 Feb 15. PubMed PMID: 28293064; PubMed Central PMCID: PMC5331293.

44: Shen H, Liu C, Zhang D, Yao X, Zhang K, Li H, Chen G. Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro. Cell Death Dis. 2017 Mar 2;8(3):e2641. doi: 10.1038/cddis.2017.58. PubMed PMID: 28252651; PubMed Central PMCID: PMC5386555.

45: Chen W, Xu XK, Li JL, Kong KK, Li H, Chen C, He J, Wang F, Li P, Ge XS, Li FC. MALAT1 is a prognostic factor in glioblastoma multiforme and induces chemoresistance to temozolomide through suppressing miR-203 and promoting thymidylate synthase expression. Oncotarget. 2017 Apr 4;8(14):22783-22799. doi: 10.18632/oncotarget.15199. PubMed PMID: 28187000; PubMed Central PMCID: PMC5410262.

46: Girault V, Gilard V, Marguet F, Lesueur C, Hauchecorne M, Ramdani Y, Laquerrière A, Marret S, Jégou S, Gonzalez BJ, Brasse-Lagnel C, Bekri S. Prenatal alcohol exposure impairs autophagy in neonatal brain cortical microvessels. Cell Death Dis. 2017 Feb 9;8(2):e2610. doi: 10.1038/cddis.2017.29. PubMed PMID: 28182007; PubMed Central PMCID: PMC5386476.

47: Bagó JR, Okolie O, Dumitru R, Ewend MG, Parker JS, Werff RV, Underhill TM, Schmid RS, Miller CR, Hingtgen SD. Tumor-homing cytotoxic human induced neural stem cells for cancer therapy. Sci Transl Med. 2017 Feb 1;9(375). pii: eaah6510. doi: 10.1126/scitranslmed.aah6510. PubMed PMID: 28148846.

48: Liu PC, Lu G, Deng Y, Wang CD, Su XW, Zhou JY, Chan TM, Hu X, Poon WS. Inhibition of NF-κB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy. PLoS One. 2017 Jan 30;12(1):e0171157. doi: 10.1371/journal.pone.0171157. eCollection 2017. PubMed PMID: 28135339; PubMed Central PMCID: PMC5279772.

49: Li J, Ren S, Liu Y, Lian Z, Dong B, Yao Y, Xu Y. Knockdown of NUPR1 inhibits the proliferation of glioblastoma cells via ERK1/2, p38 MAPK and caspase-3. J Neurooncol. 2017 Mar;132(1):15-26. doi: 10.1007/s11060-016-2337-0. Epub 2016 Dec 20. PubMed PMID: 28000106.

50: Jiang X, Fitch S, Wang C, Wilson C, Li J, Grant GA, Yang F. Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13857-13862. Epub 2016 Nov 14. PubMed PMID: 27849590; PubMed Central PMCID: PMC5137687.

51: Yigitkanli K, Zheng Y, Pekcec A, Lo EH, van Leyen K. Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia. Transl Stroke Res. 2017 Apr;8(2):194-202. doi: 10.1007/s12975-016-0509-z. Epub 2016 Nov 12. PubMed PMID: 27838820; PubMed Central PMCID: PMC5350054.

52: Jane EP, Premkumar DR, Sutera PA, Cavaleri JM, Pollack IF. Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl-xL silenced glioma cell lines. Mol Carcinog. 2017 Apr;56(4):1251-1265. doi: 10.1002/mc.22587. Epub 2016 Nov 22. PubMed PMID: 27805285.

53: Kazimirsky G, Jiang W, Slavin S, Ziv-Av A, Brodie C. Mesenchymal stem cells enhance the oncolytic effect of Newcastle disease virus in glioma cells and glioma stem cells via the secretion of TRAIL. Stem Cell Res Ther. 2016 Oct 10;7(1):149. PubMed PMID: 27724977; PubMed Central PMCID: PMC5057491.

54: Wiedemuth R, Klink B, Fujiwara M, Schröck E, Tatsuka M, Schackert G, Temme A. Janus face-like effects of Aurora B inhibition: antitumoral mode of action versus induction of aneuploid progeny. Carcinogenesis. 2016 Oct;37(10):993-1003. doi: 10.1093/carcin/bgw083. Epub 2016 Aug 11. PubMed PMID: 27515963.

55: Chi HC, Chen SL, Cheng YH, Lin TK, Tsai CY, Tsai MM, Lin YH, Huang YH, Lin KH. Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway. Cell Death Dis. 2016 Aug 4;7(8):e2324. doi: 10.1038/cddis.2016.227. PubMed PMID: 27490929; PubMed Central PMCID: PMC5108316.

56: Zhao Y, Zhao Y, Zhang M, Zhao J, Ma X, Huang T, Pang H, Li J, Song J. Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats. Mediators Inflamm. 2016;2016:4706915. doi: 10.1155/2016/4706915. Epub 2016 Jul 13. PubMed PMID: 27478307; PubMed Central PMCID: PMC4961816.

57: Teng H, Wang P, Xue Y, Liu X, Ma J, Cai H, Xi Z, Li Z, Liu Y. Role of HCP5-miR-139-RUNX1 Feedback Loop in Regulating Malignant Behavior of Glioma Cells. Mol Ther. 2016 Oct;24(10):1806-1822. doi: 10.1038/mt.2016.103. Epub 2016 Jun 2. PubMed PMID: 27434586; PubMed Central PMCID: PMC5112034.

58: Huang Y, Yang M, Hu H, Zhao X, Bao L, Huang D, Song L, Li Y. Mitochondrial GRIM-19 as a potential therapeutic target for STAT3-dependent carcinogenesis of gastric cancer. Oncotarget. 2016 Jul 5;7(27):41404-41420. doi: 10.18632/oncotarget.9167. PubMed PMID: 27167343; PubMed Central PMCID: PMC5173068.

59: Choi SA, Yun JW, Joo KM, Lee JY, Kwak PA, Lee YE, You JR, Kwon E, Kim WH, Wang KC, Phi JH, Kang BC, Kim SK. Preclinical Biosafety Evaluation of Genetically Modified Human Adipose Tissue-Derived Mesenchymal Stem Cells for Clinical Applications to Brainstem Glioma. Stem Cells Dev. 2016 Jun 15;25(12):897-908. doi: 10.1089/scd.2015.0324. Epub 2016 Jun 6. PubMed PMID: 27151205.

60: Karpel-Massler G, Horst BA, Shu C, Chau L, Tsujiuchi T, Bruce JN, Canoll P, Greene LA, Angelastro JM, Siegelin MD. A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers. Clin Cancer Res. 2016 Sep 15;22(18):4698-711. doi: 10.1158/1078-0432.CCR-15-2827. Epub 2016 Apr 28. PubMed PMID: 27126996; PubMed Central PMCID: PMC5026557.

61: Tang JH, Ma ZX, Huang GH, Xu QF, Xiang Y, Li N, Sidlauskas K, Zhang EE, Lv SQ. Downregulation of HIF-1a sensitizes U251 glioma cells to the temozolomide (TMZ) treatment. Exp Cell Res. 2016 May 1;343(2):148-158. doi: 10.1016/j.yexcr.2016.04.011. Epub 2016 Apr 21. PubMed PMID: 27090014.

62: Feng C, Luo T, Zhang S, Liu K, Zhang Y, Luo Y, Ge P. Lycopene protects human SH‑SY5Y neuroblastoma cells against hydrogen peroxide‑induced death via inhibition of oxidative stress and mitochondria‑associated apoptotic pathways. Mol Med Rep. 2016 May;13(5):4205-14. doi: 10.3892/mmr.2016.5056. Epub 2016 Mar 28. PubMed PMID: 27035331; PubMed Central PMCID: PMC4838073.

63: Wang S, Yin J, Ge M, Dai Z, Li Y, Si J, Ma K, Li L, Yao S. Transforming growth-beta 1 contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury by regulating the c-Jun N-terminal kinase signaling pathway. Biomed Pharmacother. 2016 Mar;78:280-290. doi: 10.1016/j.biopha.2016.01.030. Epub 2016 Feb 4. PubMed PMID: 26898453.

64: Zhao H, Wang C, Lu B, Zhou Z, Jin Y, Wang Z, Zheng L, Liu K, Luo T, Zhu D, Chi G, Luo Y, Ge P. Pristimerin triggers AIF-dependent programmed necrosis in glioma cells via activation of JNK. Cancer Lett. 2016 Apr 28;374(1):136-148. doi: 10.1016/j.canlet.2016.01.055. Epub 2016 Feb 17. PubMed PMID: 26854718.

65: Yang R, Yi L, Dong Z, Ouyang Q, Zhou J, Pang Y, Wu Y, Xu L, Cui H. Tigecycline Inhibits Glioma Growth by Regulating miRNA-199b-5p-HES1-AKT Pathway. Mol Cancer Ther. 2016 Mar;15(3):421-9. doi: 10.1158/1535-7163.MCT-15-0709. Epub 2016 Jan 28. PubMed PMID: 26823491.

66: Li H, Zheng J, Guan R, Zhu Z, Yuan X. Tyrphostin AG 1296 induces glioblastoma cell apoptosis in vitro and in vivo. Oncol Lett. 2015 Dec;10(6):3429-3433. Epub 2015 Oct 6. PubMed PMID: 26788146; PubMed Central PMCID: PMC4665272.

67: Cheng YC, Huang YC, Yeh TH, Shih HY, Lin CY, Lin SJ, Chiu CC, Huang CW, Jiang YJ. Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation. Neural Dev. 2015 Dec 30;10:28. doi: 10.1186/s13064-015-0055-5. PubMed PMID: 26714454; PubMed Central PMCID: PMC4696291.

68: Crommentuijn MH, Maguire CA, Niers JM, Vandertop WP, Badr CE, Würdinger T, Tannous BA. Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma. Mol Oncol. 2016 Apr;10(4):625-34. doi: 10.1016/j.molonc.2015.11.011. Epub 2015 Dec 11. PubMed PMID: 26708508; PubMed Central PMCID: PMC4826802.

69: Das A, McDonald DG, Dixon-Mah YN, Jacqmin DJ, Samant VN, Vandergrift WA 3rd, Lindhorst SM, Cachia D, Varma AK, Vanek KN, Banik NL, Jenrette JM 3rd, Raizer JJ, Giglio P, Patel SJ. RIP1 and RIP3 complex regulates radiation-induced programmed necrosis in glioblastoma. Tumour Biol. 2016 Jun;37(6):7525-34. doi: 10.1007/s13277-015-4621-6. Epub 2015 Dec 18. PubMed PMID: 26684801.

70: Ma D, Lu B, Feng C, Wang C, Wang Y, Luo T, Feng J, Jia H, Chi G, Luo Y, Ge P. Deoxypodophyllotoxin triggers parthanatos in glioma cells via induction of excessive ROS. Cancer Lett. 2016 Feb 28;371(2):194-204. doi: 10.1016/j.canlet.2015.11.044. Epub 2015 Dec 9. PubMed PMID: 26683770.

71: Lan F, Yang Y, Han J, Wu Q, Yu H, Yue X. Sulforaphane reverses chemo-resistance to temozolomide in glioblastoma cells by NF-κB-dependent pathway downregulating MGMT expression. Int J Oncol. 2016 Feb;48(2):559-68. doi: 10.3892/ijo.2015.3271. Epub 2015 Nov 27. PubMed PMID: 26648123.

72: Li W, Zhang C, Du H, Huang V, Sun B, Harris JP, Richardson Q, Shen X, Jin R, Li G, Kevil CG, Gu X, Shi R, Zhao Y. Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model. Mol Carcinog. 2016 Nov;55(11):1739-1746. doi: 10.1002/mc.22423. Epub 2015 Oct 16. PubMed PMID: 26472150.

73: Yulyana Y, Tovmasyan A, Ho IA, Sia KC, Newman JP, Ng WH, Guo CM, Hui KM, Batinic-Haberle I, Lam PY. Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme. Stem Cell Rev. 2016 Feb;12(1):140-55. doi: 10.1007/s12015-015-9628-2. PubMed PMID: 26454429; PubMed Central PMCID: PMC4926165.

74: Hashemi M, Fallah A, Aghayan HR, Arjmand B, Yazdani N, Verdi J, Ghodsi SM, Miri SM, Hadjighassem M. A New Approach in Gene Therapy of Glioblastoma Multiforme: Human Olfactory Ensheathing Cells as a Novel Carrier for Suicide Gene Delivery. Mol Neurobiol. 2016 Oct;53(8):5118-28. doi: 10.1007/s12035-015-9412-y. Epub 2015 Sep 22. PubMed PMID: 26395282.

75: Xu B, Jiang C, Han H, Liu H, Tang M, Liu L, Ji W, Lu X, Yang X, Zhang Y, Liu Y. Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling. Clin Exp Pharmacol Physiol. 2015 Dec;42(12):1296-307. doi: 10.1111/1440-1681.12488. PubMed PMID: 26356761.

76: Zhou X, Shen F, Ma P, Hui H, Pei S, Chen M, Wang Z, Zhou W, Jin B. GSK1838705A, an IGF-1R inhibitor, inhibits glioma cell proliferation and suppresses tumor growth in vivo. Mol Med Rep. 2015 Oct;12(4):5641-6. doi: 10.3892/mmr.2015.4129. Epub 2015 Jul 28. PubMed PMID: 26238593; PubMed Central PMCID: PMC4581800.

77: Zhao Y, Li Y, Ma Y, Wang S, Cheng J, Yang T, Sun Z, Kuang Y, Huang H, Fan K, Gu J. Myocyte enhancer factor 2D promotes tumorigenicity in malignant glioma cells. Tumour Biol. 2016 Jan;37(1):601-10. doi: 10.1007/s13277-015-3791-6. Epub 2015 Aug 4. PubMed PMID: 26234765.

78: Zhitao J, Long L, Jia L, Yunchao B, Anhua W. Temozolomide sensitizes stem-like cells of glioma spheres to TRAIL-induced apoptosis via upregulation of casitas B-lineage lymphoma (c-Cbl) protein. Tumour Biol. 2015 Dec;36(12):9621-30. doi: 10.1007/s13277-015-3720-8. Epub 2015 Jul 6. PubMed PMID: 26142735.

79: Gao W, Zhao Z, Yu G, Zhou Z, Zhou Y, Hu T, Jiang R, Zhang J. VEGI attenuates the inflammatory injury and disruption of blood-brain barrier partly by suppressing the TLR4/NF-κB signaling pathway in experimental traumatic brain injury. Brain Res. 2015 Oct 5;1622:230-9. doi: 10.1016/j.brainres.2015.04.035. Epub 2015 Jun 12. PubMed PMID: 26080076.

80: Foster KA, Jane EP, Premkumar DR, Morales A, Pollack IF. NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5. Int J Oncol. 2015 Aug;47(2):506-16. doi: 10.3892/ijo.2015.3035. Epub 2015 Jun 5. PubMed PMID: 26044191; PubMed Central PMCID: PMC4501659.

81: Sirianni AC, Jiang J, Zeng J, Mao LL, Zhou S, Sugarbaker P, Zhang X, Li W, Friedlander RM, Wang X. N-acetyl-l-tryptophan, but not N-acetyl-d-tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis. J Neurochem. 2015 Sep;134(5):956-68. doi: 10.1111/jnc.13190. Epub 2015 Jul 14. PubMed PMID: 26031348.

82: Choi SA, Lee YE, Kwak PA, Lee JY, Kim SS, Lee SJ, Phi JH, Wang KC, Song J, Song SH, Joo KM, Kim SK. Clinically applicable human adipose tissue-derived mesenchymal stem cells delivering therapeutic genes to brainstem gliomas. Cancer Gene Ther. 2015 Jun;22(6):302-11. doi: 10.1038/cgt.2015.25. Epub 2015 May 29. PubMed PMID: 26021486.

83: Ciaglia E, Torelli G, Pisanti S, Picardi P, D'Alessandro A, Laezza C, Malfitano AM, Fiore D, Pagano Zottola AC, Proto MC, Catapano G, Gazzerro P, Bifulco M. Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients' cells. Oncotarget. 2015 Jun 20;6(17):15464-81. PubMed PMID: 26008966; PubMed Central PMCID: PMC4558164.

84: Ren H, Gao Z, Wu N, Zeng L, Tang X, Chen X, Liu Z, Zhang W, Wang L, Li Z. Expression of REST4 in human gliomas in vivo and influence of pioglitazone on REST in vitro. Biochem Biophys Res Commun. 2015 Aug 7;463(4):504-9. doi: 10.1016/j.bbrc.2015.05.058. Epub 2015 May 21. PubMed PMID: 26003726.

85: Lu L, Li ZJ, Li LF, Wu WK, Shen J, Zhang L, Chan RL, Yu L, Liu YW, Ren SX, Chan KM, Cho CH. Vascular-targeted TNFα improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer. J Control Release. 2015 Jul 28;210:134-46. doi: 10.1016/j.jconrel.2015.05.282. Epub 2015 May 21. PubMed PMID: 26003042.

86: Cao L, Lei H, Chang MZ, Liu ZQ, Bie XH. Down-regulation of 14-3-3β exerts anti-cancer effects through inducing ER stress in human glioma U87 cells: Involvement of CHOP-Wnt pathway. Biochem Biophys Res Commun. 2015 Jul 10;462(4):389-95. doi: 10.1016/j.bbrc.2015.05.003. Epub 2015 May 14. PubMed PMID: 25982477.

87: Li W, Zhang C, Ren A, Li T, Jin R, Li G, Gu X, Shi R, Zhao Y. Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation. PLoS One. 2015 May 11;10(5):e0126459. doi: 10.1371/journal.pone.0126459. eCollection 2015. PubMed PMID: 25961580; PubMed Central PMCID: PMC4427333.

88: Dolenec P, Pilipović K, Rajič J, Župan G. Temporal pattern of neurodegeneration, programmed cell death, and neuroplastic responses in the thalamus after lateral fluid percussion brain injury in the rat. J Neuropathol Exp Neurol. 2015 Jun;74(6):512-26. doi: 10.1097/NEN.0000000000000194. PubMed PMID: 25933386.

89: Miao YF, Wu H, Yang SF, Dai J, Qiu YM, Tao ZY, Zhang XH. 5'-adenosine monophosphate-induced hypothermia attenuates brain ischemia/reperfusion injury in a rat model by inhibiting the inflammatory response. Mediators Inflamm. 2015;2015:520745. doi: 10.1155/2015/520745. Epub 2015 Mar 22. PubMed PMID: 25873763; PubMed Central PMCID: PMC4385688.

90: Zeng Z, Liu H, Jiang D. [NRH2 induces cell apoptosis of cerebral tissues around hematomas after intracerebral hemorrhage through up-regulating proNGF, sortilin and p75NTR expressions]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 Apr;31(4):532-6, 539. Chinese. PubMed PMID: 25854576.

91: Sun G, Yan S, Shi L, Wan Z, Jiang N, Li M, Guo J. Decreased Expression of miR-15b in Human Gliomas is Associated with Poor Prognosis. Cancer Biother Radiopharm. 2015 May;30(4):169-73. doi: 10.1089/cbr.2014.1757. Epub 2015 Mar 26. PubMed PMID: 25811315; PubMed Central PMCID: PMC4426309.

92: Sie M, den Dunnen WF, Lourens HJ, Meeuwsen-de Boer TG, Scherpen FJ, Zomerman WW, Kampen KR, Hoving EW, de Bont ES. Growth-factor-driven rescue to receptor tyrosine kinase (RTK) inhibitors through Akt and Erk phosphorylation in pediatric low grade astrocytoma and ependymoma. PLoS One. 2015 Mar 23;10(3):e0122555. doi: 10.1371/journal.pone.0122555. eCollection 2015. PubMed PMID: 25799134; PubMed Central PMCID: PMC4370756.

93: Shi L, Wang Z, Sun G. Curcumin induces glioma stem-like cell formation. Neuroreport. 2015 Feb 11;26(3):167-72. doi: 10.1097/WNR.0000000000000320. PubMed PMID: 25602852.

94: Han H, Xu B, Hou P, Jiang C, Liu L, Tang M, Yang X, Zhang Y, Liu Y. Icaritin Sensitizes Human Glioblastoma Cells to TRAIL-Induced Apoptosis. Cell Biochem Biophys. 2015 Jun;72(2):533-42. doi: 10.1007/s12013-014-0499-y. PubMed PMID: 25577511.

95: Karpel-Massler G, Pareja F, Aimé P, Shu C, Chau L, Westhoff MA, Halatsch ME, Crary JF, Canoll P, Siegelin MD. PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma. PLoS One. 2014 Dec 22;9(12):e114583. doi: 10.1371/journal.pone.0114583. eCollection 2014. PubMed PMID: 25531448; PubMed Central PMCID: PMC4273972.

96: Wu Q, Zhang XS, Wang HD, Zhang X, Yu Q, Li W, Zhou ML, Wang XL. Astaxanthin activates nuclear factor erythroid-related factor 2 and the antioxidant responsive element (Nrf2-ARE) pathway in the brain after subarachnoid hemorrhage in rats and attenuates early brain injury. Mar Drugs. 2014 Dec 18;12(12):6125-41. doi: 10.3390/md12126125. PubMed PMID: 25528957; PubMed Central PMCID: PMC4278222.

97: Chakraborty S, Li L, Puliyappadamba VT, Guo G, Hatanpaa KJ, Mickey B, Souza RF, Vo P, Herz J, Chen MR, Boothman DA, Pandita TK, Wang DH, Sen GC, Habib AA. Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks. Nat Commun. 2014 Dec 15;5:5811. doi: 10.1038/ncomms6811. PubMed PMID: 25503978; PubMed Central PMCID: PMC4268886.

98: Premkumar DR, Jane EP, Pollack IF. Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells. Cancer Biol Ther. 2015;16(2):233-43. doi: 10.4161/15384047.2014.987548. PubMed PMID: 25482928; PubMed Central PMCID: PMC4623008.

99: Koschny R, Krupp W, Xu LX, Mueller WC, Bauer M, Sinn P, Keller M, Koschny T, Walczak H, Bruckner T, Ganten TM, Holland H. WHO grade related expression of TRAIL-receptors and apoptosis regulators in meningioma. Pathol Res Pract. 2015 Feb;211(2):109-16. doi: 10.1016/j.prp.2014.11.002. Epub 2014 Nov 13. PubMed PMID: 25481563.

100: Hatipoglu G, Hock SW, Weiss R, Fan Z, Sehm T, Ghoochani A, Buchfelder M, Savaskan NE, Eyüpoglu IY. Sunitinib impedes brain tumor progression and reduces tumor-induced neurodegeneration in the microenvironment. Cancer Sci. 2015 Feb;106(2):160-70. doi: 10.1111/cas.12580. Epub 2015 Feb 15. PubMed PMID: 25458015; PubMed Central PMCID: PMC4399021.

101: Koschny R, Boehm C, Sprick MR, Haas TL, Holland H, Xu LX, Krupp W, Mueller WC, Bauer M, Koschny T, Keller M, Sinn P, Meixensberger J, Walczak H, Ganten TM. Bortezomib sensitizes primary meningioma cells to TRAIL-induced apoptosis by enhancing formation of the death-inducing signaling complex. J Neuropathol Exp Neurol. 2014 Nov;73(11):1034-46. doi: 10.1097/NEN.0000000000000129. PubMed PMID: 25289891.

102: Ma J, Yao Y, Wang P, Liu Y, Zhao L, Li Z, Li Z, Xue Y. MiR-152 functions as a tumor suppressor in glioblastoma stem cells by targeting Krüppel-like factor 4. Cancer Lett. 2014 Dec 1;355(1):85-95. doi: 10.1016/j.canlet.2014.09.012. Epub 2014 Sep 10. PubMed PMID: 25218589.

103: Chang H, Song S, Chen Z, Wang Y, Yang L, Du M, Ke Y, Xu R, Jin B, Jiang X. Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cells. Neural Regen Res. 2014 Mar 1;9(5):519-25. doi: 10.4103/1673-5374.130079. PubMed PMID: 25206849; PubMed Central PMCID: PMC4153508.

104: Liang C, Guo S, Yang L. Effects of all‑trans retinoic acid on VEGF and HIF‑1α expression in glioma cells under normoxia and hypoxia and its anti‑angiogenic effect in an intracerebral glioma model. Mol Med Rep. 2014 Nov;10(5):2713-9. doi: 10.3892/mmr.2014.2543. Epub 2014 Sep 5. PubMed PMID: 25201493.

105: Redjal N, Zhu Y, Shah K. Combination of systemic chemotherapy with local stem cell delivered S-TRAIL in resected brain tumors. Stem Cells. 2015 Jan;33(1):101-10. doi: 10.1002/stem.1834. PubMed PMID: 25186100; PubMed Central PMCID: PMC4270944.

106: Zhang Y, Ren X, Shi M, Jiang Z, Wang H, Su Q, Liu Q, Li G, Jiang G. Downregulation of STAT3 and activation of MAPK are involved in the induction of apoptosis by HNK in glioblastoma cell line U87. Oncol Rep. 2014 Nov;32(5):2038-46. doi: 10.3892/or.2014.3434. Epub 2014 Aug 22. PubMed PMID: 25175884.

107: Feng T, Liu Y, Li C, Li Z. Protective effects of nigranoic acid on cerebral ischemia-reperfusion injury and its mechanism involving apoptotic signaling pathway. Cell Biochem Biophys. 2015 Jan;71(1):345-51. doi: 10.1007/s12013-014-0204-1. PubMed PMID: 25168103.

108: Foster KA, Jane EP, Premkumar DR, Morales A, Pollack IF. Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines. J Neurooncol. 2014 Dec;120(3):459-72. doi: 10.1007/s11060-014-1575-2. Epub 2014 Aug 20. PubMed PMID: 25139025.

109: Mishiro K, Imai T, Sugitani S, Kitashoji A, Suzuki Y, Takagi T, Chen H, Oumi Y, Tsuruma K, Shimazawa M, Hara H. Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis. PLoS One. 2014 Aug 18;9(8):e103818. doi: 10.1371/journal.pone.0103818. eCollection 2014. PubMed PMID: 25133692; PubMed Central PMCID: PMC4136737.

110: Liu YJ, Lin YC, Lee JC, Kuo SC, Ho CT, Huang LJ, Kuo DH, Way TD. CCT327 enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistant human leukemia cells. Oncol Rep. 2014 Sep;32(3):1257-64. doi: 10.3892/or.2014.3317. Epub 2014 Jul 10. PubMed PMID: 25017974.

111: Jiang J, Yu S, Jiang Z, Liang C, Yu W, Li J, Du X, Wang H, Gao X, Wang X. N-acetyl-serotonin protects HepG2 cells from oxidative stress injury induced by hydrogen peroxide. Oxid Med Cell Longev. 2014;2014:310504. doi: 10.1155/2014/310504. Epub 2014 Jun 12. PubMed PMID: 25013541; PubMed Central PMCID: PMC4074966.

112: Ahn Y, Oh S, Lee SJ, Park BG, Park YS, Shin WS, Jang HJ, Park JH, Kwon D, Lee S. Synthesis of diethylamino-curcumin mimics with substituted triazolyl groups and their sensitization effect of TRAIL against brain cancer cells. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3346-50. doi: 10.1016/j.bmcl.2014.05.098. Epub 2014 Jun 6. PubMed PMID: 24961640.

113: Liu J, Liu L, Xue Y, Meng F, Li S, Wang P, Liu Y. Anti-neoplastic activity of low-dose endothelial-monocyte activating polypeptide-II results from defective autophagy and G2/M arrest mediated by PI3K/Akt/FoxO1 axis in human glioblastoma stem cells. Biochem Pharmacol. 2014 Jun 15;89(4):477-89. doi: 10.1016/j.bcp.2014.04.014. Epub 2014 Apr 30. PubMed PMID: 24792437.

114: Chen JC, Hwang JH, Chiu WH, Chan YC. Tetrandrine and caffeine modulated cell cycle and increased glioma cell death via caspase-dependent and caspase-independent apoptosis pathways. Nutr Cancer. 2014;66(4):700-6. doi: 10.1080/01635581.2014.902974. Epub 2014 Apr 16. PubMed PMID: 24738643.

115: Zhou H, Wang J, Jiang J, Stavrovskaya IG, Li M, Li W, Wu Q, Zhang X, Luo C, Zhou S, Sirianni AC, Sarkar S, Kristal BS, Friedlander RM, Wang X. N-acetyl-serotonin offers neuroprotection through inhibiting mitochondrial death pathways and autophagic activation in experimental models of ischemic injury. J Neurosci. 2014 Feb 19;34(8):2967-78. doi: 10.1523/JNEUROSCI.1948-13.2014. PubMed PMID: 24553937; PubMed Central PMCID: PMC3929763.

116: Li S, Zhu JH, Cao LP, Sun Q, Liu HD, Li WD, Li JS, Hang CH. Growth inhibitory in vitro effects of glycyrrhizic acid in U251 glioblastoma cell line. Neurol Sci. 2014 Jul;35(7):1115-20. doi: 10.1007/s10072-014-1661-4. Epub 2014 Feb 11. PubMed PMID: 24514918.

117: Lee DH, Kim DW, Lee HC, Lee JH, Lee TH. Phenethyl isothiocyanate sensitizes glioma cells to TRAIL-induced apoptosis. Biochem Biophys Res Commun. 2014 Apr 18;446(4):815-21. doi: 10.1016/j.bbrc.2014.01.112. Epub 2014 Jan 31. PubMed PMID: 24491546.

118: Kim SM, Woo JS, Jeong CH, Ryu CH, Jang JD, Jeun SS. Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma. Stem Cells Transl Med. 2014 Feb;3(2):172-82. doi: 10.5966/sctm.2013-0132. Epub 2014 Jan 16. PubMed PMID: 24436439; PubMed Central PMCID: PMC3925057.

119: Czubowicz K, Strosznajder R. Ceramide in the molecular mechanisms of neuronal cell death. The role of sphingosine-1-phosphate. Mol Neurobiol. 2014 Aug;50(1):26-37. doi: 10.1007/s12035-013-8606-4. Epub 2014 Jan 14. PubMed PMID: 24420784; PubMed Central PMCID: PMC4181317.

120: Tu J, Li Y, Hu Z, Chen Z. Radiosurgery inhibition of the Notch signaling pathway in a rat model of arteriovenous malformations. J Neurosurg. 2014 Jun;120(6):1385-96. doi: 10.3171/2013.12.JNS131595. Epub 2014 Jan 10. PubMed PMID: 24410155.

121: Zhang J, Zhao C, Gao Y, Jiang Y, Liang H, Zhao G. Thiabendazole, a well-known antifungal drug, exhibits anti-metastatic melanoma B16F10 activity via inhibiting VEGF expression and inducing apoptosis. Pharmazie. 2013 Dec;68(12):962-8. PubMed PMID: 24400443.

122: Zhang Y, Chen X, Lian H, Liu J, Zhou B, Han S, Peng B, Yin J, Liu W, He X. MicroRNA-503 acts as a tumor suppressor in glioblastoma for multiple antitumor effects by targeting IGF-1R. Oncol Rep. 2014 Mar;31(3):1445-52. doi: 10.3892/or.2013.2951. Epub 2013 Dec 30. PubMed PMID: 24378652; PubMed Central PMCID: PMC4440219.

123: Pease M, Ling C, Mack WJ, Wang K, Zada G. The role of epigenetic modification in tumorigenesis and progression of pituitary adenomas: a systematic review of the literature. PLoS One. 2013 Dec 18;8(12):e82619. doi: 10.1371/journal.pone.0082619. eCollection 2013. Review. PubMed PMID: 24367530; PubMed Central PMCID: PMC3867353.

124: Zhang H, Tian M, Xiu C, Wang Y, Tang G. Enhancement of antitumor activity by combination of tumor lysate-pulsed dendritic cells and celecoxib in a rat glioma model. Oncol Res. 2013;20(10):447-55. PubMed PMID: 24308155.

125: Liu Y, Nakamura T, Toyoshima T, Lu F, Sumitani K, Shinomiya A, Keep RF, Yamamoto T, Tamiya T, Itano T. Ameliorative effects of yokukansan on behavioral deficits in a gerbil model of global cerebral ischemia. Brain Res. 2014 Jan 16;1543:300-7. doi: 10.1016/j.brainres.2013.11.015. Epub 2013 Nov 19. PubMed PMID: 24269335.

126: Wang JF, Li Y, Song JN, Pang HG. Role of hydrogen sulfide in secondary neuronal injury. Neurochem Int. 2014 Jan;64:37-47. doi: 10.1016/j.neuint.2013.11.002. Epub 2013 Nov 14. Review. PubMed PMID: 24239876.

127: Shetty PK, Galeffi F, Turner DA. Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia. Neurobiol Dis. 2014 Feb;62:469-78. doi: 10.1016/j.nbd.2013.10.025. Epub 2013 Oct 31. PubMed PMID: 24184921; PubMed Central PMCID: PMC4143422.

128: Lee DH, Lee CS, Kim DW, Ae JE, Lee TH. Digitoxin sensitizes glioma cells to TRAIL-mediated apoptosis by upregulation of death receptor 5 and downregulation of survivin. Anticancer Drugs. 2014 Jan;25(1):44-52. doi: 10.1097/CAD.0000000000000015. PubMed PMID: 24045365.

129: Chen S, Ma Q, Krafft PR, Hu Q, Rolland W 2nd, Sherchan P, Zhang J, Tang J, Zhang JH. P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH. Neurobiol Dis. 2013 Oct;58:296-307. doi: 10.1016/j.nbd.2013.06.011. Epub 2013 Jun 29. PubMed PMID: 23816751; PubMed Central PMCID: PMC3771387.

130: Premkumar DR, Jane EP, Foster KA, Pollack IF. Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway. J Pharmacol Exp Ther. 2013 Aug;346(2):201-10. doi: 10.1124/jpet.113.204743. Epub 2013 Jun 5. PubMed PMID: 23740602; PubMed Central PMCID: PMC3716309.

131: Nassehi D. Intracranial meningiomas, the VEGF-A pathway, and peritumoral brain oedema. Dan Med J. 2013 Apr;60(4):B4626. Review. PubMed PMID: 23651727.

132: Bao XJ, Liu FY, Lu S, Han Q, Feng M, Wei JJ, Li GL, Zhao RC, Wang RZ. Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model. Int J Mol Med. 2013 May;31(5):1087-96. doi: 10.3892/ijmm.2013.1290. Epub 2013 Mar 5. PubMed PMID: 23468083.

133: Bo Y, Guo G, Yao W. MiRNA-mediated tumor specific delivery of TRAIL reduced glioma growth. J Neurooncol. 2013 Mar;112(1):27-37. doi: 10.1007/s11060-012-1033-y. Epub 2013 Jan 22. PubMed PMID: 23338605.

134: Xu H, Luo P, Zhao Y, Zhao M, Yang Y, Chen T, Huo K, Han H, Fei Z. Iduna protects HT22 cells from hydrogen peroxide-induced oxidative stress through interfering poly(ADP-ribose) polymerase-1-induced cell death (parthanatos). Cell Signal. 2013 Apr;25(4):1018-26. doi: 10.1016/j.cellsig.2013.01.006. Epub 2013 Jan 16. PubMed PMID: 23333241.

135: Zhou Y, Wang HD, Zhu L, Cong ZX, Li N, Ji XJ, Pan H, Wang JW, Li WC. Knockdown of Nrf2 enhances autophagy induced by temozolomide in U251 human glioma cell line. Oncol Rep. 2013 Jan;29(1):394-400. doi: 10.3892/or.2012.2115. Epub 2012 Oct 31. PubMed PMID: 23128449.

136: Qiu B, Sun X, Zhang D, Wang Y, Tao J, Ou S. TRAIL and paclitaxel synergize to kill U87 cells and U87-derived stem-like cells in vitro. Int J Mol Sci. 2012;13(7):9142-56. doi: 10.3390/ijms13079142. Epub 2012 Jul 20. PubMed PMID: 22942757; PubMed Central PMCID: PMC3430288.

137: Cho HY, Wang W, Jhaveri N, Torres S, Tseng J, Leong MN, Lee DJ, Goldkorn A, Xu T, Petasis NA, Louie SG, Schönthal AH, Hofman FM, Chen TC. Perillyl alcohol for the treatment of temozolomide-resistant gliomas. Mol Cancer Ther. 2012 Nov;11(11):2462-72. doi: 10.1158/1535-7163.MCT-12-0321. Epub 2012 Aug 28. PubMed PMID: 22933703.

138: Lee DH, Lee TH, Jung CH, Kim YH. Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. Cell Signal. 2012 Nov;24(11):2216-25. doi: 10.1016/j.cellsig.2012.07.019. Epub 2012 Jul 28. PubMed PMID: 22846543.

139: Xie Z, Lei B, Huang Q, Deng J, Wu M, Shen W, Cheng Y. Neuroprotective effect of Cyclosporin A on the development of early brain injury in a subarachnoid hemorrhage model: a pilot study. Brain Res. 2012 Sep 7;1472:113-23. doi: 10.1016/j.brainres.2012.06.053. Epub 2012 Jul 11. PubMed PMID: 22796593.

140: Chiou SM, Chiu CH, Yang ST, Yang JS, Huang HY, Kuo CL, Chen PY, Chung JG. Danthron triggers ROS and mitochondria-mediated apoptotic death in C6 rat glioma cells through caspase cascades, apoptosis-inducing factor and endonuclease G multiple signaling. Neurochem Res. 2012 Aug;37(8):1790-800. doi: 10.1007/s11064-012-0792-3. Epub 2012 May 17. PubMed PMID: 22592642.

141: Wang Z, Ma C, Meng CJ, Zhu GQ, Sun XB, Huo L, Zhang J, Liu HX, He WC, Shen XM, Shu Z, Chen G. Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. J Pineal Res. 2012 Sep;53(2):129-37. doi: 10.1111/j.1600-079X.2012.00978.x. Epub 2012 Feb 3. PubMed PMID: 22304528.

142: Kim GS, Jung JE, Narasimhan P, Sakata H, Yoshioka H, Song YS, Okami N, Chan PH. Release of mitochondrial apoptogenic factors and cell death are mediated by CK2 and NADPH oxidase. J Cereb Blood Flow Metab. 2012 Apr;32(4):720-30. doi: 10.1038/jcbfm.2011.176. Epub 2011 Dec 7. PubMed PMID: 22146192; PubMed Central PMCID: PMC3318149.

143: Harada S, Suzuki SO, Seki Y, Nakamura S, Iwaki T. Differential activation of proapoptotic molecules between mouse and rat models of distal motor trigeminal denervation. J Oral Pathol Med. 2012 Apr;41(4):354-60. doi: 10.1111/j.1600-0714.2011.01109.x. Epub 2011 Nov 16. PubMed PMID: 22084907.

144: Wan W, Zhu J, Sun X, Tang W. Small interfering RNA targeting Krüppel-like factor 8 inhibits U251 glioblastoma cell growth by inducing apoptosis. Mol Med Rep. 2012 Feb;5(2):347-50. doi: 10.3892/mmr.2011.669. Epub 2011 Nov 8. PubMed PMID: 22076119.

145: Yu W, Mechawar N, Krantic S, Quirion R. α7 Nicotinic receptor activation reduces β-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling. J Neurochem. 2011 Nov;119(4):848-58. doi: 10.1111/j.1471-4159.2011.07466.x. Epub 2011 Oct 3. PubMed PMID: 21884524.

146: Qi L, Bellail AC, Rossi MR, Zhang Z, Pang H, Hunter S, Cohen C, Moreno CS, Olson JJ, Li S, Hao C. Heterogeneity of primary glioblastoma cells in the expression of caspase-8 and the response to TRAIL-induced apoptosis. Apoptosis. 2011 Nov;16(11):1150-64. doi: 10.1007/s10495-011-0645-6. PubMed PMID: 21877214; PubMed Central PMCID: PMC3257579.

147: Yang G, Zhang R, Chen X, Mu Y, Ai J, Shi C, Liu Y, Shi C, Sun L, Rainov NG, Li H, Yang B, Zhao S. MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status. J Mol Med (Berl). 2011 Oct;89(10):1037-50. doi: 10.1007/s00109-011-0775-x. Epub 2011 Jun 9. PubMed PMID: 21656380.

148: Chen G, Fang Q, Zhang J, Zhou D, Wang Z. Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage. J Neurosci Res. 2011 Apr;89(4):515-23. doi: 10.1002/jnr.22577. Epub 2011 Jan 21. PubMed PMID: 21259333.

149: Jane EP, Premkumar DR, Pollack IF. Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway. Mol Cancer Ther. 2011 Jan;10(1):198-208. doi: 10.1158/1535-7163.MCT-10-0725. PubMed PMID: 21220502; PubMed Central PMCID: PMC3075591.

150: Ko JK, Choi CH, Kim YK, Kwon CH. The proteasome inhibitor MG-132 induces AIF nuclear translocation through down-regulation of ERK and Akt/mTOR pathway. Neurochem Res. 2011 May;36(5):722-31. doi: 10.1007/s11064-010-0387-9. Epub 2011 Jan 4. PubMed PMID: 21203833.

151: Salehi F, Agur A, Scheithauer BW, Kovacs K, Lloyd RV, Cusimano M. Biomarkers of pituitary neoplasms: a review (Part II). Neurosurgery. 2010 Dec;67(6):1790-8; discussion 1798. doi: 10.1227/NEU.0b013e3181faa680. Review. PubMed PMID: 21107210.

152: Chen J, Wu X, Shao B, Zhao W, Shi W, Zhang S, Ni L, Shen A. Increased expression of TNF receptor-associated factor 6 after rat traumatic brain injury. Cell Mol Neurobiol. 2011 Mar;31(2):269-75. doi: 10.1007/s10571-010-9617-6. Epub 2010 Nov 12. PubMed PMID: 21072581.

153: Choi SA, Hwang SK, Wang KC, Cho BK, Phi JH, Lee JY, Jung HW, Lee DH, Kim SK. Therapeutic efficacy and safety of TRAIL-producing human adipose tissue-derived mesenchymal stem cells against experimental brainstem glioma. Neuro Oncol. 2011 Jan;13(1):61-9. doi: 10.1093/neuonc/noq147. Epub 2010 Nov 9. PubMed PMID: 21062796; PubMed Central PMCID: PMC3018907.

154: Zhang J, Zhu Y, Zhou D, Wang Z, Chen G. Recombinant human erythropoietin (rhEPO) alleviates early brain injury following subarachnoid hemorrhage in rats: possible involvement of Nrf2-ARE pathway. Cytokine. 2010 Dec;52(3):252-7. doi: 10.1016/j.cyto.2010.08.011. Epub 2010 Sep 22. PubMed PMID: 20864352.

155: Premkumar DR, Jane EP, Pollack IF. Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines. Int J Oncol. 2010 Sep;37(3):633-43. PubMed PMID: 20664932.

156: Chen J, Sun X, Yang W, Jiang G, Li X. Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11. PubMed PMID: 20623264.

157: Tsai FC, Hsieh MS, Chou CM. Comparison between neurectomy and botulinum toxin A injection for denervated skeletal muscle. J Neurotrauma. 2010 Aug;27(8):1509-16. doi: 10.1089/neu.2010.1320. PubMed PMID: 20528164.

158: Nagane M, Shimizu S, Mori E, Kataoka S, Shiokawa Y. Predominant antitumor effects by fully human anti-TRAIL-receptor 2 (DR5) monoclonal antibodies in human glioma cells in vitro and in vivo. Neuro Oncol. 2010 Jul;12(7):687-700. doi: 10.1093/neuonc/nop069. Epub 2010 Feb 11. PubMed PMID: 20511188; PubMed Central PMCID: PMC2940669.

159: Strosznajder RP, Czubowicz K, Jesko H, Strosznajder JB. Poly(ADP-ribose) metabolism in brain and its role in ischemia pathology. Mol Neurobiol. 2010 Jun;41(2-3):187-96. doi: 10.1007/s12035-010-8124-6. Epub 2010 Apr 23. Review. PubMed PMID: 20411356.

160: Xu Y, Zhang Y, Liu X, Wang Z, Ma J, Wang J, Yue W. The effects of ultrasound and arsenic trioxide on neurogliocytoma cells and secondary activation of macrophages. Tumori. 2009 Nov-Dec;95(6):780-8. PubMed PMID: 20210244.

161: Kuijlen JM, Bremer E, Mooij JJ, den Dunnen WF, Helfrich W. Review: on TRAIL for malignant glioma therapy? Neuropathol Appl Neurobiol. 2010 Apr;36(3):168-82. doi: 10.1111/j.1365-2990.2010.01069.x. Epub 2010 Jan 20. Review. PubMed PMID: 20102513.

162: Liebelt B, Papapetrou P, Ali A, Guo M, Ji X, Peng C, Rogers R, Curry A, Jimenez D, Ding Y. Exercise preconditioning reduces neuronal apoptosis in stroke by up-regulating heat shock protein-70 (heat shock protein-72) and extracellular-signal-regulated-kinase 1/2. Neuroscience. 2010 Apr 14;166(4):1091-100. doi: 10.1016/j.neuroscience.2009.12.067. Epub 2010 Jan 18. PubMed PMID: 20083167.

163: Tang C, Xue HL, Huang HB, Wang XG. Tanshinone IIA inhibits constitutive STAT3 activation, suppresses proliferation, and induces apoptosis in rat C6 glioma cells. Neurosci Lett. 2010 Feb 12;470(2):126-9. doi: 10.1016/j.neulet.2009.12.069. Epub 2010 Jan 5. PubMed PMID: 20045721.

164: Cheng G, Chunlei W, Pei W, Zhen L, Xiangzhen L. Simvastatin activates Akt/glycogen synthase kinase-3beta signal and inhibits caspase-3 activation after experimental subarachnoid hemorrhage. Vascul Pharmacol. 2010 Jan-Feb;52(1-2):77-83. doi: 10.1016/j.vph.2009.12.001. Epub 2009 Dec 18. PubMed PMID: 20004738.

165: Shen J, Li G, Liu Q, He Q, Gu J, Shi Y, Lou H. Marchantin C: a potential anti-invasion agent in glioma cells. Cancer Biol Ther. 2010 Jan;9(1):33-9. Epub 2010 Jan 9. PubMed PMID: 19923918.

166: Niizuma K, Yoshioka H, Chen H, Kim GS, Jung JE, Katsu M, Okami N, Chan PH. Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Biochim Biophys Acta. 2010 Jan;1802(1):92-9. doi: 10.1016/j.bbadis.2009.09.002. Epub 2009 Sep 12. Review. PubMed PMID: 19751828; PubMed Central PMCID: PMC2790539.

167: Yang B, Wu X, Mao Y, Bao W, Gao L, Zhou P, Xie R, Zhou L, Zhu J. Dual-targeted antitumor effects against brainstem glioma by intravenous delivery of tumor necrosis factor-related, apoptosis-inducing, ligand-engineered human mesenchymal stem cells. Neurosurgery. 2009 Sep;65(3):610-24; discussion 624. doi: 10.1227/01.NEU.0000350227.61132.A7. PubMed PMID: 19687708.

168: Menon LG, Kelly K, Yang HW, Kim SK, Black PM, Carroll RS. Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy. Stem Cells. 2009 Sep;27(9):2320-30. doi: 10.1002/stem.136. PubMed PMID: 19544410.

169: Schley M, Ständer S, Kerner J, Vajkoczy P, Schüpfer G, Dusch M, Schmelz M, Konrad C. Predominant CB2 receptor expression in endothelial cells of glioblastoma in humans. Brain Res Bull. 2009 Jun 30;79(5):333-7. doi: 10.1016/j.brainresbull.2009.01.011. Epub 2009 Feb 6. PubMed PMID: 19480992.

170: Jin W, Wang HD, Hu ZG, Yan W, Chen G, Yin HX. Transcription factor Nrf2 plays a pivotal role in protection against traumatic brain injury-induced acute intestinal mucosal injury in mice. J Surg Res. 2009 Dec;157(2):251-60. doi: 10.1016/j.jss.2008.08.003. Epub 2008 Sep 4. PubMed PMID: 19394962.

171: Jin W, Wang H, Ji Y, Zhu L, Yan W, Qiao L, Yin H. Genetic ablation of Nrf2 enhances susceptibility to acute lung injury after traumatic brain injury in mice. Exp Biol Med (Maywood). 2009 Feb;234(2):181-9. doi: 10.3181/0807-RM-232. PubMed PMID: 19176347.

172: Jin W, Wang H, Yan W, Zhu L, Hu Z, Ding Y, Tang K. Role of Nrf2 in protection against traumatic brain injury in mice. J Neurotrauma. 2009 Jan;26(1):131-9. doi: 10.1089/neu.2008.0655. PubMed PMID: 19125683.

173: Yu WR, Liu T, Fehlings TK, Fehlings MG. Involvement of mitochondrial signaling pathways in the mechanism of Fas-mediated apoptosis after spinal cord injury. Eur J Neurosci. 2009 Jan;29(1):114-31. doi: 10.1111/j.1460-9568.2008.06555.x. PubMed PMID: 19120440.

174: Stendel R, Biefer HR, Dékány GM, Kubota H, Münz C, Wang S, Mohler H, Yonekawa Y, Frei K. The antibacterial substance taurolidine exhibits anti-neoplastic action based on a mixed type of programmed cell death. Autophagy. 2009 Feb;5(2):194-210. Epub 2009 Feb 13. PubMed PMID: 19066471.

175: Wang XY, Li XL, Hong SQ, Xi-Yang YB, Wang TH. Electroacupuncture induced spinal plasticity is linked to multiple gene expressions in dorsal root deafferented rats. J Mol Neurosci. 2009 Feb;37(2):97-110. doi: 10.1007/s12031-008-9095-1. Epub 2008 Jun 26. PubMed PMID: 18581269.

176: Zeng Y, Yang Z, Han YY, You C. [Impact of all-trans retinoic acid on gene expression profile of glioblastoma cell line SHG-44]. Ai Zheng. 2008 May;27(5):482-90. Chinese. PubMed PMID: 18479597.

177: Zhao S, Zhang X, Zhang J, Zhang J, Zou H, Liu Y, Dong X, Sun X. Intravenous administration of arsenic trioxide encapsulated in liposomes inhibits the growth of C6 gliomas in rat brains. J Chemother. 2008 Apr;20(2):253-62. PubMed PMID: 18467254.

178: Gu J, Li G, Sun T, Su Y, Zhang X, Shen J, Tian Z, Zhang J. Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells. J Neurooncol. 2008 Aug;89(1):9-17. doi: 10.1007/s11060-008-9590-9. Epub 2008 Apr 16. PubMed PMID: 18415045.

179: Hetschko H, Voss V, Seifert V, Prehn JH, Kögel D. Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis. FEBS J. 2008 Apr;275(8):1925-36. doi: 10.1111/j.1742-4658.2008.06351.x. Epub 2008 Mar 13. PubMed PMID: 18341587.

180: Zhang WH, Wang H, Wang X, Narayanan MV, Stavrovskaya IG, Kristal BS, Friedlander RM. Nortriptyline protects mitochondria and reduces cerebral ischemia/hypoxia injury. Stroke. 2008 Feb;39(2):455-62. doi: 10.1161/STROKEAHA.107.496810. Epub 2008 Jan 3. PubMed PMID: 18174477; PubMed Central PMCID: PMC2632945.

181: Sung JH, Zhao H, Roy M, Sapolsky RM, Steinberg GK. Viral caspase inhibitor p35, but not crmA, is neuroprotective in the ischemic penumbra following experimental stroke. Neuroscience. 2007 Nov 23;149(4):804-12. Epub 2007 Jul 26. PubMed PMID: 17945431; PubMed Central PMCID: PMC2144739.

182: Kang DW, Choi CH, Park JY, Kang SK, Kim YK. Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells. Neurochem Res. 2008 Mar;33(3):551-61. Epub 2007 Oct 17. PubMed PMID: 17940898.

183: Chan DY, Chen GG, Poon WS, Liu PC. Lovastatin sensitized human glioblastoma cells to TRAIL-induced apoptosis. J Neurooncol. 2008 Feb;86(3):273-83. Epub 2007 Oct 11. PubMed PMID: 17928957; PubMed Central PMCID: PMC2174520.

184: Zhao H, Wang JQ, Shimohata T, Sun G, Yenari MA, Sapolsky RM, Steinberg GK. Conditions of protection by hypothermia and effects on apoptotic pathways in a rat model of permanent middle cerebral artery occlusion. J Neurosurg. 2007 Sep;107(3):636-41. PubMed PMID: 17886565.

185: Fujiwara K, Iwado E, Mills GB, Sawaya R, Kondo S, Kondo Y. Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy. Int J Oncol. 2007 Oct;31(4):753-60. PubMed PMID: 17786305.

186: Shinojima N, Yokoyama T, Kondo Y, Kondo S. Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy. 2007 Nov-Dec;3(6):635-7. Epub 2007 Aug 21. PubMed PMID: 17786026.

187: Zohrabian VM, Nandu H, Gulati N, Khitrov G, Zhao C, Mohan A, Demattia J, Braun A, Das K, Murali R, Jhanwar-Uniyal M. Gene expression profiling of metastatic brain cancer. Oncol Rep. 2007 Aug;18(2):321-8. PubMed PMID: 17611651.

188: Gomel R, Xiang C, Finniss S, Lee HK, Lu W, Okhrimenko H, Brodie C. The localization of protein kinase Cdelta in different subcellular sites affects its proapoptotic and antiapoptotic functions and the activation of distinct downstream signaling pathways. Mol Cancer Res. 2007 Jun;5(6):627-39. PubMed PMID: 17579121.

189: Uzzaman M, Keller G, Germano IM. Enhanced proapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on temozolomide-resistant glioma cells. J Neurosurg. 2007 Apr;106(4):646-51. PubMed PMID: 17432717.

190: Nagane M, Cavenee WK, Shiokawa Y. Synergistic cytotoxicity through the activation of multiple apoptosis pathways in human glioma cells induced by combined treatment with ionizing radiation and tumor necrosis factor-related apoptosis-inducing ligand. J Neurosurg. 2007 Mar;106(3):407-16. PubMed PMID: 17367063.

191: Zhang Y, Park TS, Gidday JM. Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2573-81. Epub 2007 Mar 2. PubMed PMID: 17337592.

192: Ragel BT, Gillespie DL, Kushnir V, Polevaya N, Kelly D, Jensen RL. Calcium channel antagonists augment hydroxyurea- and ru486-induced inhibition of meningioma growth in vivo and in vitro. Neurosurgery. 2006 Nov;59(5):1109-20; discussion 1120-1. PubMed PMID: 17143245.

193: Cho WH, Choi CH, Park JY, Kang SK, Kim YK. 15-deoxy-(Delta12,14)-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells. Neurochem Res. 2006 Oct;31(10):1247-54. PubMed PMID: 17006759.

194: Jane EP, Premkumar DR, Pollack IF. Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. J Pharmacol Exp Ther. 2006 Dec;319(3):1070-80. Epub 2006 Sep 7. PubMed PMID: 16959960.

195: Germano IM, Uzzaman M, Benveniste RJ, Zaurova M, Keller G. Apoptosis in human glioblastoma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand. J Neurosurg. 2006 Jul;105(1):88-95. PubMed PMID: 16871882.

196: Yu F, Sugawara T, Nishi T, Liu J, Chan PH. Overexpression of SOD1 in transgenic rats attenuates nuclear translocation of endonuclease G and apoptosis after spinal cord injury. J Neurotrauma. 2006 May;23(5):595-603. PubMed PMID: 16689664.

197: Kuijlen JM, Mooij JJ, Platteel I, Hoving EW, van der Graaf WT, Span MM, Hollema H, den Dunnen WF. TRAIL-receptor expression is an independent prognostic factor for survival in patients with a primary glioblastoma multiforme. J Neurooncol. 2006 Jun;78(2):161-71. Epub 2006 Mar 17. PubMed PMID: 16544055.

198: Premkumar DR, Arnold B, Jane EP, Pollack IF. Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells. Mol Carcinog. 2006 Jan;45(1):47-59. PubMed PMID: 16267832.

199: Uzzaman M, Benveniste RJ, Keller G, Germano IM. Embryonic stem cell-derived astrocytes: a novel gene therapy vector for brain tumors. Neurosurg Focus. 2005 Sep 15;19(3):E6. PubMed PMID: 16190605.

200: Ueda Y, Nakagawa T, Kubota T, Ido K, Sato K. Glioma cells under hypoxic conditions block the brain microvascular endothelial cell death induced by serum starvation. J Neurochem. 2005 Oct;95(1):99-110. Epub 2005 Jul 22. PubMed PMID: 16042757.

201: Rodak R, Kubota H, Ishihara H, Eugster HP, Könü D, Möhler H, Yonekawa Y, Frei K. Induction of reactive oxygen intermediates-dependent programmed cell death in human malignant ex vivo glioma cells and inhibition of the vascular endothelial growth factor production by taurolidine. J Neurosurg. 2005 Jun;102(6):1055-68. PubMed PMID: 16028765.

202: Feng KK, Zhao HY, Qiu H, Chen J. [Specific anti-glioma angiogenesis immune response induced by attenuated Salmonella typhimurium vaccine expressing vascular endothelial growth factor receptor-2]. Ai Zheng. 2005 May;24(5):548-53. Chinese. PubMed PMID: 15890095.

203: Jaganathan J, Petit JH, Lazio BE, Singh SK, Chin LS. Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in established and primary glioma cell lines. Neurosurg Focus. 2002 Sep 15;13(3):ecp1. PubMed PMID: 15844877.

204: Siu PM, Alway SE. Mitochondria-associated apoptotic signalling in denervated rat skeletal muscle. J Physiol. 2005 May 15;565(Pt 1):309-23. Epub 2005 Mar 17. PubMed PMID: 15774533; PubMed Central PMCID: PMC1464486.

205: Puduvalli VK, Li JT, Chen L, McCutcheon IE. Induction of apoptosis in primary meningioma cultures by fenretinide. Cancer Res. 2005 Feb 15;65(4):1547-53. PubMed PMID: 15735044.

206: Zhang Y, Zhang X, Park TS, Gidday JM. Cerebral endothelial cell apoptosis after ischemia-reperfusion: role of PARP activation and AIF translocation. J Cereb Blood Flow Metab. 2005 Jul;25(7):868-77. PubMed PMID: 15729291.

207: Fukami T, Nakasu S, Baba K, Nakajima M, Matsuda M. Hyperthermia induces translocation of apoptosis-inducing factor (AIF) and apoptosis in human glioma cell lines. J Neurooncol. 2004 Dec;70(3):319-31. PubMed PMID: 15662973.

208: Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med. 2004 Dec;10(12):1379-83. Epub 2004 Oct 31. PubMed PMID: 15516929.

209: Kasuga C, Ebata T, Kayagaki N, Yagita H, Hishii M, Arai H, Sato K, Okumura K. Sensitization of human glioblastomas to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by NF-kappaB inhibitors. Cancer Sci. 2004 Oct;95(10):840-4. PubMed PMID: 15504253.

210: Hatano M, Mizuno M, Yoshida J. Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells. J Neurosurg. 2004 Jul;101(1):119-27. PubMed PMID: 15255262.

211: Daido S, Kanzawa T, Yamamoto A, Takeuchi H, Kondo Y, Kondo S. Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res. 2004 Jun 15;64(12):4286-93. PubMed PMID: 15205343.

212: Zhao H, Yenari MA, Cheng D, Barreto-Chang OL, Sapolsky RM, Steinberg GK. Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat. J Cereb Blood Flow Metab. 2004 Jun;24(6):681-92. PubMed PMID: 15181376.

213: Szeifert GT, Figarella-Branger D, Roche PH, Régis J. Histopathological observations on vestibular schwannomas after Gamma Knife radiosurgery: the Marseille experience. Neurochirurgie. 2004 Jun;50(2-3 Pt 2):327-37. PubMed PMID: 15179286.

214: Plesnila N, Zhu C, Culmsee C, Gröger M, Moskowitz MA, Blomgren K. Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia. J Cereb Blood Flow Metab. 2004 Apr;24(4):458-66. PubMed PMID: 15087715.

215: Erber R, Thurnher A, Katsen AD, Groth G, Kerger H, Hammes HP, Menger MD, Ullrich A, Vajkoczy P. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J. 2004 Feb;18(2):338-40. Epub 2003 Dec 4. PubMed PMID: 14657001.

216: Hayashi T, Saito A, Okuno S, Ferrand-Drake M, Dodd RL, Nishi T, Maier CM, Kinouchi H, Chan PH. Oxidative damage to the endoplasmic reticulum is implicated in ischemic neuronal cell death. J Cereb Blood Flow Metab. 2003 Oct;23(10):1117-28. PubMed PMID: 14526222.

217: Wang X, Zhu S, Drozda M, Zhang W, Stavrovskaya IG, Cattaneo E, Ferrante RJ, Kristal BS, Friedlander RM. Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10483-7. Epub 2003 Aug 20. PubMed PMID: 12930891; PubMed Central PMCID: PMC193587.

218: Petratos S, Butzkueven H, Shipham K, Cooper H, Bucci T, Reid K, Lopes E, Emery B, Cheema SS, Kilpatrick TJ. Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor. J Neuropathol Exp Neurol. 2003 Apr;62(4):398-411. PubMed PMID: 12722832.

219: Raza SM, Lang FF, Aggarwal BB, Fuller GN, Wildrick DM, Sawaya R. Necrosis and glioblastoma: a friend or a foe? A review and a hypothesis. Neurosurgery. 2002 Jul;51(1):2-12; discussion 12-3. Review. PubMed PMID: 12182418.

220: Ikeda J, Tada M, Ishii N, Saya H, Tsuchiya K, Okaichi K, Mishima K, Sawamura Y, Fulci G, Liu TJ, Van Meir EG. Restoration of endogenous wild-type p53 activity in a glioblastoma cell line with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis. Int J Cancer. 2001 Oct 1;94(1):35-43. PubMed PMID: 11668476; PubMed Central PMCID: PMC2819747.

221: Ivanchuk SM, Mondal S, Dirks PB, Rutka JT. The INK4A/ARF locus: role in cell cycle control and apoptosis and implications for glioma growth. J Neurooncol. 2001 Feb;51(3):219-29. Review. PubMed PMID: 11407594.

222: Nagane M, Huang HJ, Cavenee WK. The potential of TRAIL for cancer chemotherapy. Apoptosis. 2001 Jun;6(3):191-7. Review. PubMed PMID: 11388668.

223: Pollack IF, Erff M, Ashkenazi A. Direct stimulation of apoptotic signaling by soluble Apo2l/tumor necrosis factor-related apoptosis-inducing ligand leads to selective killing of glioma cells. Clin Cancer Res. 2001 May;7(5):1362-9. PubMed PMID: 11350907.

224: Weber RG, Rieger J, Naumann U, Lichter P, Weller M. Chromosomal imbalances associated with response to chemotherapy and cytotoxic cytokines in human malignant glioma cell lines. Int J Cancer. 2001 Jan 15;91(2):213-8. PubMed PMID: 11146447.

225: Syroid DE, Maycox PJ, Soilu-Hänninen M, Petratos S, Bucci T, Burrola P, Murray S, Cheema S, Lee KF, Lemke G, Kilpatrick TJ. Induction of postnatal schwann cell death by the low-affinity neurotrophin receptor in vitro and after axotomy. J Neurosci. 2000 Aug 1;20(15):5741-7. PubMed PMID: 10908614.

226: Khalid MH, Shibata S, Hiura T. Effects of clotrimazole on the growth, morphological characteristics, and cisplatin sensitivity of human glioblastoma cells in vitro. J Neurosurg. 1999 May;90(5):918-27. PubMed PMID: 10223459.

227: Trachtenberg JT, Thompson WJ. Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor. Nature. 1996 Jan 11;379(6561):174-7. PubMed PMID: 8538769.

Chen W, Liu H, Wang T, Bao G, Wang N, Li RC. Downregulation of AIF-2 Inhibits Proliferation, Migration, and Invasion of Human Glioma Cells via Mitochondrial Dysfunction. J Mol Neurosci. 2019 Apr 13. doi: 10.1007/s12031-019-01306-y. [Epub ahead of print] PubMed PMID: 30982162.
apoptosis_inducing_factor.txt · Last modified: 2019/09/01 21:52 by administrador