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apoptosis_inducing_factor

Apoptosis inducing factor

Apoptosis inducing factor (AIF) is a family of mitochondrial oxidoreductases that play important roles in mitochondrial metabolism and redox control. AIF-1 has been demonstrated to exert cell-killing effect via apoptosis in cancer cells, whereas the role of AIF-2 in cancer cells has not been determined.

A study of Chen et al., aimed to investigate the role of AIF-2 in human glioma cells. They found that AIF-2 was upregulated in human glioma tissues and cell lines, especially in U251 cells. Downregulation of AIF-2 using specific siRNA (Si-AIF-2) significantly reduced cell proliferation, induced G1 cell cycle arrest and differently regulated the expression of cell cycle regulator proteins in U251 cells. In addition, the results of Matrigel invasion assay and live-cell tracking assay showed that knockdown of AIF-2 inhibited cell invasion and migration. The results of immunocytochemistry indicated that knockdown of AIF-2 significantly attenuated the nuclear translocation of AIF-1, which was confirmed by western blot analysis. Furthermore, downregulation of AIF-2 resulted in mitochondrial dysfunction in U251 cells, as evidenced by reduced mitochondrial membrane potential (MMP), mitochondrial complex I activity, and mitochondrial Ca2+ buffering capacity.

In conclusion, they found that AIF-2 plays a key role in promoting cell proliferation, invasion, and migration via regulating AIF-1-related mitochondrial cascades. Downregulation of the candidate oncogene AIF-2 might constitute a strategy to kill human glioma cells 1).

Unclassified

1: Chen W, Liu H, Wang T, Bao G, Wang N, Li RC. Downregulation of AIF-2 Inhibits Proliferation, Migration, and Invasion of Human Glioma Cells via Mitochondrial Dysfunction. J Mol Neurosci. 2019 Apr 13. doi: 10.1007/s12031-019-01306-y. [Epub ahead of print] PubMed PMID: 30982162.

2: Li M, Sun S, Dangelmajer S, Zhang Q, Wang J, Hu F, Dong F, Kahlert UD, Zhu M, Lei T. Exploiting tumor-intrinsic signals to induce mesenchymal stem cell-mediated suicide gene therapy to fight malignant glioma. Stem Cell Res Ther. 2019 Mar 12;10(1):88. doi: 10.1186/s13287-019-1194-0. PubMed PMID: 30867058; PubMed Central PMCID: PMC6417183.

3: Li M, Zeng L, Liu S, Dangelmajer S, Kahlert UD, Huang H, Han Y, Chi X, Zhu M, Lei T. Transforming Growth Factor-β Promotes Homing and Therapeutic Efficacy of Human Mesenchymal Stem Cells to Glioblastoma. J Neuropathol Exp Neurol. 2019 Apr 1;78(4):315-325. doi: 10.1093/jnen/nlz016. PubMed PMID: 30863846.

4: Yang Y, Liang S, Li Y, Gao F, Cao Y, Zhao X, Gao G, Li L. Effects of early administration of insulin-like growth factor-1 on cognitive function in septic encephalopathy. Neuropsychiatr Dis Treat. 2019 Jan 23;15:323-337. doi: 10.2147/NDT.S190845. eCollection 2019. PubMed PMID: 30774344; PubMed Central PMCID: PMC6353230.

5: Cho HY, Thein TZ, Wang W, Swenson SD, Fayngor RA, Ou M, Marín-Ramos NI, Schönthal AH, Hofman FM, Chen TC. The Rolipram-Perillyl Alcohol Conjugate (NEO214) Is A Mediator of Cell Death through the Death Receptor Pathway. Mol Cancer Ther. 2019 Mar;18(3):517-530. doi: 10.1158/1535-7163.MCT-18-0465. Epub 2019 Jan 15. PubMed PMID: 30647121.

6: Chen CH, Chen PY, Lin YY, Feng LY, Chen SH, Chen CY, Huang YC, Huang CY, Jung SM, Chen LY, Wei KC. Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma. J Neurosurg. 2019 Jan 11:1-12. doi: 10.3171/2018.8.JNS181217. [Epub ahead of print] PubMed PMID: 30641835.

7: Mohebbi A, Ebrahimzadeh MS, Baghban Rahimi S, Saeidi M, Tabarraei A, Mohebbi SR, Shirian S, Gorji A, Ghaemi A. Non-replicating Newcastle Disease Virus as an adjuvant for DNA vaccine enhances antitumor efficacy through the induction of TRAIL and granzyme B expression. Virus Res. 2019 Feb;261:72-80. doi: 10.1016/j.virusres.2018.12.014. Epub 2018 Dec 29. PubMed PMID: 30599161.

8: Huang N, Zhang X, Jiang Y, Mei H, Zhang L, Zhang Q, Hu J, Chen B. Increased levels of serum pigment epithelium-derived factor aggravate proteinuria via induction of podocyte actin rearrangement. Int Urol Nephrol. 2019 Feb;51(2):359-367. doi: 10.1007/s11255-018-2026-3. Epub 2018 Dec 7. PubMed PMID: 30536192; PubMed Central PMCID: PMC6394770.

9: Golinelli G, Grisendi G, Prapa M, Bestagno M, Spano C, Rossignoli F, Bambi F, Sardi I, Cellini M, Horwitz EM, Feletti A, Pavesi G, Dominici M. Targeting GD2-positive glioblastoma by chimeric antigen receptor empowered mesenchymal progenitors. Cancer Gene Ther. 2018 Nov 22. doi: 10.1038/s41417-018-0062-x. [Epub ahead of print] PubMed PMID: 30464207.

10: Lu JH, Peng BY, Chang CC, Dubey NK, Lo WC, Cheng HC, Wang JR, Wei HJ, Deng WP. Tumor-Targeted Immunotherapy by Using Primary Adipose-Derived Stem Cells and an Antigen-Specific Protein Vaccine. Cancers (Basel). 2018 Nov 15;10(11). pii: E446. doi: 10.3390/cancers10110446. PubMed PMID: 30445793; PubMed Central PMCID: PMC6266266.

11: Wang R, Bao H, Zhang S, Li R, Chen L, Zhu Y. miR-186-5p Promotes Apoptosis by Targeting IGF-1 in SH-SY5Y OGD/R Model. Int J Biol Sci. 2018 Oct 19;14(13):1791-1799. doi: 10.7150/ijbs.25352. eCollection 2018. PubMed PMID: 30443183; PubMed Central PMCID: PMC6231212.

12: Choi SA, Lee C, Kwak PA, Park CK, Wang KC, Phi JH, Lee JY, Chong S, Kim SK. Histone deacetylase inhibitor panobinostat potentiates the anti-cancer effects of mesenchymal stem cell-based sTRAIL gene therapy against malignant glioma. Cancer Lett. 2019 Feb 1;442:161-169. doi: 10.1016/j.canlet.2018.10.012. Epub 2018 Oct 24. PubMed PMID: 30367915.

13: Tsai YR, Chang CF, Lai JH, Wu JC, Chen YH, Kang SJ, Hoffer BJ, Tweedie D, Luo W, Greig NH, Chiang YH, Chen KY. Pomalidomide Ameliorates H₂O₂-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects. Int J Mol Sci. 2018 Oct 19;19(10). pii: E3252. doi: 10.3390/ijms19103252. PubMed PMID: 30347766; PubMed Central PMCID: PMC6213994.

14: Lu J, Li Q, Cai L, Zhu Z, Guan J, Wang C, Xia J, Xia L, Wen M, Zheng W, Su Z, Wang C. RBM17 controls apoptosis and proliferation to promote Glioma progression. Biochem Biophys Res Commun. 2018 Oct 20;505(1):20-28. doi: 10.1016/j.bbrc.2018.09.056. Epub 2018 Sep 15. PubMed PMID: 30227940.

15: Xiao X, Wang W, Li Y, Yang D, Li X, Shen C, Liu Y, Ke X, Guo S, Guo Z. HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma. J Exp Clin Cancer Res. 2018 Aug 28;37(1):201. doi: 10.1186/s13046-018-0880-6. PubMed PMID: 30153855; PubMed Central PMCID: PMC6114771.

16: Xu ZF, Sun XK, Chen G, Han C, Wang F, Zhang YD. Oroxyloside inhibits human glioma progression by suppressing proliferation, metastasis and inducing apoptosis related pathways. Biomed Pharmacother. 2018 Jan;97:1564-1574. doi: 10.1016/j.biopha.2017.09.100. Epub 2017 Nov 24. PubMed PMID: 29793319.

17: Yu Z, Chen Y, Wang S, Li P, Zhou G, Yuan Y. Inhibition of NF-κB results in anti-glioma activity and reduces temozolomide-induced chemoresistance by down-regulating MGMT gene expression. Cancer Lett. 2018 Aug 1;428:77-89. doi: 10.1016/j.canlet.2018.04.033. Epub 2018 Apr 27. PubMed PMID: 29705182.

18: He Y, Meng H, Xu H, Fan L, Zhou Z, Xu B, Sun L, Gao Y. Regulation of Integrated Stress Response Sensitizes U87MG Glioblastoma Cells to Temozolomide Through the Mitochondrial Apoptosis Pathway. Anat Rec (Hoboken). 2018 Apr 26. doi: 10.1002/ar.23839. [Epub ahead of print] PubMed PMID: 29698579.

19: Cai X, Yang Y, Xia W, Kong H, Wang M, Fu W, Long M, Hu Y, Xu D. RIP2 promotes glioma cell growth by regulating TRAF3 and activating the NF‑κB and p38 signaling pathways. Oncol Rep. 2018 Jun;39(6):2915-2923. doi: 10.3892/or.2018.6397. Epub 2018 Apr 23. PubMed PMID: 29693188.

20: Liang SD, Ma LQ, Gao ZY, Zhuang YY, Zhao YZ. Granulocyte colony-stimulating factor improves neurological function and angiogenesis in intracerebral hemorrhage rats. Eur Rev Med Pharmacol Sci. 2018 Apr;22(7):2005-2014. doi: 10.26355/eurrev_201804_14729. PubMed PMID: 29687856.

21: Ma L, Niu W, Yang S, Tian J, Luan H, Cao M, Xi W, Tu W, Jia J, Lv J. Inhibition of mitochondrial permeability transition pore opening contributes to cannabinoid type 1 receptor agonist ACEA-induced neuroprotection. Neuropharmacology. 2018 Jun;135:211-222. doi: 10.1016/j.neuropharm.2018.03.024. Epub 2018 Mar 21. PubMed PMID: 29574098.

22: Cao YX, Wang ZQ, Kang JX, Liu K, Zhao CF, Guo YX, Jiao BH. miR-424 protects PC-12 cells from OGD-induced injury by negatively regulating MKP-1. Eur Rev Med Pharmacol Sci. 2018 Mar;22(5):1426-1436. doi: 10.26355/eurrev_201803_14490. PubMed PMID: 29565504.

23: Di H, Zhang X, Guo Y, Shi Y, Fang C, Yuan Y, Wang J, Shang C, Guo W, Li C. Silencing LDHA inhibits proliferation, induces apoptosis and increases chemosensitivity to temozolomide in glioma cells. Oncol Lett. 2018 Apr;15(4):5131-5136. doi: 10.3892/ol.2018.7932. Epub 2018 Feb 2. PubMed PMID: 29552147; PubMed Central PMCID: PMC5840669.

24: Meng C, Zhang J, Dang B, Li H, Shen H, Li X, Wang Z. PERK Pathway Activation Promotes Intracerebral Hemorrhage Induced Secondary Brain Injury by Inducing Neuronal Apoptosis Both in Vivo and in Vitro. Front Neurosci. 2018 Feb 28;12:111. doi: 10.3389/fnins.2018.00111. eCollection 2018. PubMed PMID: 29541018; PubMed Central PMCID: PMC5835756.

25: Zhang W, Xiong Z, Wei T, Li Q, Tan Y, Ling L, Feng X. Nuclear factor 90 promotes angiogenesis by regulating HIF-1α/VEGF-A expression through the PI3K/Akt signaling pathway in human cervical cancer. Cell Death Dis. 2018 Feb 15;9(3):276. doi: 10.1038/s41419-018-0334-2. PubMed PMID: 29449553; PubMed Central PMCID: PMC5833414.

26: Wang Z, Liu Z, Yu G, Nie X, Jia W, Liu RE, Xu R. Paeoniflorin Inhibits Migration and Invasion of Human Glioblastoma Cells via Suppression Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition. Neurochem Res. 2018 Mar;43(3):760-774. doi: 10.1007/s11064-018-2478-y. Epub 2018 Feb 8. PubMed PMID: 29423667; PubMed Central PMCID: PMC5842263.

27: Tanrikulu B, Ziyal I, Bayri Y. In Vitro Effects of Mesenchymal Stem Cells and Various Agents on Apoptosis of Glioblastoma Cells. Turk Neurosurg. 2019;29(1):26-32. doi: 10.5137/1019-5149.JTN.21827-17.2. PubMed PMID: 29384188.

28: Wang FZ, Dai XL, Liu HY. Molecular mechanisms underlying the α-tomatine-directed apoptosis in human malignant glioblastoma cell lines A172 and U-118 MG. Exp Ther Med. 2017 Dec;14(6):6183-6192. doi: 10.3892/etm.2017.5294. Epub 2017 Oct 12. PubMed PMID: 29250143; PubMed Central PMCID: PMC5729398.

29: Hung CM, Liu LC, Ho CT, Lin YC, Way TD. Pterostilbene Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors and Downregulation of Cell Survival Proteins in TRAIL-Resistance Triple Negative Breast Cancer Cells. J Agric Food Chem. 2017 Dec 27;65(51):11179-11191. doi: 10.1021/acs.jafc.7b02358. Epub 2017 Dec 15. PubMed PMID: 29164887.

30: Luan W, Qian Y, Ni X, Chanda TK, Xia Y, Wang J, Yan Y, Xu B. Polygonatum odoratum lectin promotes BECN1 expression and induces autophagy in malignant melanoma by regulation of miR1290. Onco Targets Ther. 2017 Sep 14;10:4569-4577. doi: 10.2147/OTT.S147406. eCollection 2017. PubMed PMID: 29066911; PubMed Central PMCID: PMC5604572.

31: Bhere D, Tamura K, Wakimoto H, Choi SH, Purow B, Debatisse J, Shah K. microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis. Neuro Oncol. 2018 Jan 22;20(2):215-224. doi: 10.1093/neuonc/nox138. PubMed PMID: 29016934; PubMed Central PMCID: PMC5777493.

32: Xu ZF, Sun XK, Lan Y, Han C, Zhang YD, Chen G. Linarin sensitizes tumor necrosis factor-related apoptosis (TRAIL)-induced ligand-triggered apoptosis in human glioma cells and in xenograft nude mice. Biomed Pharmacother. 2017 Nov;95:1607-1618. doi: 10.1016/j.biopha.2017.08.021. Epub 2017 Oct 6. PubMed PMID: 28950661.

33: Wang SS, Feng L, Hu BG, Lu YF, Wang WM, Guo W, Suen CW, Jiao BH, Pang JX, Fu WM, Zhang JF. miR-133a Promotes TRAIL Resistance in Glioblastoma via Suppressing Death Receptor 5 and Activating NF-κB Signaling. Mol Ther Nucleic Acids. 2017 Sep 15;8:482-492. doi: 10.1016/j.omtn.2017.07.015. Epub 2017 Aug 4. PubMed PMID: 28918048; PubMed Central PMCID: PMC5560119.

34: Phi JH, Choi SA, Kwak PA, Lee JY, Wang KC, Hwang DW, Kim SK. Panobinostat, a histone deacetylase inhibitor, suppresses leptomeningeal seeding in a medulloblastoma animal model. Oncotarget. 2017 May 24;8(34):56747-56757. doi: 10.18632/oncotarget.18132. eCollection 2017 Aug 22. PubMed PMID: 28915627; PubMed Central PMCID: PMC5593598.

35: Zhen ZG, Ren SH, Ji HM, Ma JH, Ding XM, Feng FQ, Chen SL, Zou P, Ren JR, Jia L. Linarin suppresses glioma through inhibition of NF-κB/p65 and up-regulating p53 expression in vitro and in vivo. Biomed Pharmacother. 2017 Nov;95:363-374. doi: 10.1016/j.biopha.2017.08.023. Epub 2017 Sep 12. PubMed PMID: 28858735.

36: Xie Y, Wanggou S, Liu Q, Li X, Liu J, Wu M. A brain-specific isoform of apoptosis-inducing factor 2 attenuates ischemia-induced oxidative stress in HT22 cells. Neurochem Int. 2018 Jan;112:179-186. doi: 10.1016/j.neuint.2017.07.006. Epub 2017 Jul 18. PubMed PMID: 28732772.

37: Zhu Y, Bassoff N, Reinshagen C, Bhere D, Nowicki MO, Lawler SE, Roux J, Shah K. Bi-specific molecule against EGFR and death receptors simultaneously targets proliferation and death pathways in tumors. Sci Rep. 2017 Jun 1;7(1):2602. doi: 10.1038/s41598-017-02483-9. PubMed PMID: 28572590; PubMed Central PMCID: PMC5454031.

38: Yang Z, Jiang B, Wang Y, Ni H, Zhang J, Xia J, Shi M, Hung LM, Ruan J, Mak TW, Li Q, Han J. 2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter. Cell Rep. 2017 May 30;19(9):1846-1857. doi: 10.1016/j.celrep.2017.05.012. PubMed PMID: 28564603.

39: Li J, Wang F, Wang G, Sun Y, Cai J, Liu X, Zhang J, Lu X, Li Y, Chen M, Chen L, Jiang C. Combination epidermal growth factor receptor variant III peptide-pulsed dendritic cell vaccine with miR-326 results in enhanced killing on EGFRvIII-positive cells. Oncotarget. 2017 Apr 18;8(16):26256-26268. doi: 10.18632/oncotarget.15445. PubMed PMID: 28412740; PubMed Central PMCID: PMC5432254.

40: Lee WS, Jung JH, Panchanathan R, Yun JW, Kim DH, Kim HJ, Kim GS, Ryu CH, Shin SC, Hong SC, Choi YH, Jung JM. Ursodeoxycholic Acid Induces Death Receptor-mediated Apoptosis in Prostate Cancer Cells. J Cancer Prev. 2017 Mar;22(1):16-21. doi: 10.15430/JCP.2017.22.1.16. Epub 2017 Mar 30. PubMed PMID: 28382282; PubMed Central PMCID: PMC5380185.

41: Tzeng SY, Wilson DR, Hansen SK, Quiñones-Hinojosa A, Green JJ. Polymeric nanoparticle-based delivery of TRAIL DNA for cancer-specific killing. Bioeng Transl Med. 2016 Jun;1(2):149-159. doi: 10.1002/btm2.10019. PubMed PMID: 28349127; PubMed Central PMCID: PMC5365091.

42: Gao C, Yu H, Yan C, Zhao W, Liu Y, Zhang D, Li J, Liu N. X-linked inhibitor of apoptosis inhibits apoptosis and preserves the blood-brain barrier after experimental subarachnoid hemorrhage. Sci Rep. 2017 Mar 22;7:44918. doi: 10.1038/srep44918. PubMed PMID: 28327595; PubMed Central PMCID: PMC5361183.

43: Zhao Y, Zhao J, Zhang M, Zhao Y, Li J, Ma X, Huang T, Pang H, Wang B, Song J. Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats. Mediators Inflamm. 2017;2017:1570917. doi: 10.1155/2017/1570917. Epub 2017 Feb 15. PubMed PMID: 28293064; PubMed Central PMCID: PMC5331293.

44: Shen H, Liu C, Zhang D, Yao X, Zhang K, Li H, Chen G. Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro. Cell Death Dis. 2017 Mar 2;8(3):e2641. doi: 10.1038/cddis.2017.58. PubMed PMID: 28252651; PubMed Central PMCID: PMC5386555.

45: Chen W, Xu XK, Li JL, Kong KK, Li H, Chen C, He J, Wang F, Li P, Ge XS, Li FC. MALAT1 is a prognostic factor in glioblastoma multiforme and induces chemoresistance to temozolomide through suppressing miR-203 and promoting thymidylate synthase expression. Oncotarget. 2017 Apr 4;8(14):22783-22799. doi: 10.18632/oncotarget.15199. PubMed PMID: 28187000; PubMed Central PMCID: PMC5410262.

46: Girault V, Gilard V, Marguet F, Lesueur C, Hauchecorne M, Ramdani Y, Laquerrière A, Marret S, Jégou S, Gonzalez BJ, Brasse-Lagnel C, Bekri S. Prenatal alcohol exposure impairs autophagy in neonatal brain cortical microvessels. Cell Death Dis. 2017 Feb 9;8(2):e2610. doi: 10.1038/cddis.2017.29. PubMed PMID: 28182007; PubMed Central PMCID: PMC5386476.

47: Bagó JR, Okolie O, Dumitru R, Ewend MG, Parker JS, Werff RV, Underhill TM, Schmid RS, Miller CR, Hingtgen SD. Tumor-homing cytotoxic human induced neural stem cells for cancer therapy. Sci Transl Med. 2017 Feb 1;9(375). pii: eaah6510. doi: 10.1126/scitranslmed.aah6510. PubMed PMID: 28148846.

48: Liu PC, Lu G, Deng Y, Wang CD, Su XW, Zhou JY, Chan TM, Hu X, Poon WS. Inhibition of NF-κB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy. PLoS One. 2017 Jan 30;12(1):e0171157. doi: 10.1371/journal.pone.0171157. eCollection 2017. PubMed PMID: 28135339; PubMed Central PMCID: PMC5279772.

49: Li J, Ren S, Liu Y, Lian Z, Dong B, Yao Y, Xu Y. Knockdown of NUPR1 inhibits the proliferation of glioblastoma cells via ERK1/2, p38 MAPK and caspase-3. J Neurooncol. 2017 Mar;132(1):15-26. doi: 10.1007/s11060-016-2337-0. Epub 2016 Dec 20. PubMed PMID: 28000106.

50: Jiang X, Fitch S, Wang C, Wilson C, Li J, Grant GA, Yang F. Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13857-13862. Epub 2016 Nov 14. PubMed PMID: 27849590; PubMed Central PMCID: PMC5137687.

51: Yigitkanli K, Zheng Y, Pekcec A, Lo EH, van Leyen K. Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia. Transl Stroke Res. 2017 Apr;8(2):194-202. doi: 10.1007/s12975-016-0509-z. Epub 2016 Nov 12. PubMed PMID: 27838820; PubMed Central PMCID: PMC5350054.

52: Jane EP, Premkumar DR, Sutera PA, Cavaleri JM, Pollack IF. Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl-xL silenced glioma cell lines. Mol Carcinog. 2017 Apr;56(4):1251-1265. doi: 10.1002/mc.22587. Epub 2016 Nov 22. PubMed PMID: 27805285.

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55: Chi HC, Chen SL, Cheng YH, Lin TK, Tsai CY, Tsai MM, Lin YH, Huang YH, Lin KH. Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway. Cell Death Dis. 2016 Aug 4;7(8):e2324. doi: 10.1038/cddis.2016.227. PubMed PMID: 27490929; PubMed Central PMCID: PMC5108316.

56: Zhao Y, Zhao Y, Zhang M, Zhao J, Ma X, Huang T, Pang H, Li J, Song J. Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats. Mediators Inflamm. 2016;2016:4706915. doi: 10.1155/2016/4706915. Epub 2016 Jul 13. PubMed PMID: 27478307; PubMed Central PMCID: PMC4961816.

57: Teng H, Wang P, Xue Y, Liu X, Ma J, Cai H, Xi Z, Li Z, Liu Y. Role of HCP5-miR-139-RUNX1 Feedback Loop in Regulating Malignant Behavior of Glioma Cells. Mol Ther. 2016 Oct;24(10):1806-1822. doi: 10.1038/mt.2016.103. Epub 2016 Jun 2. PubMed PMID: 27434586; PubMed Central PMCID: PMC5112034.

58: Huang Y, Yang M, Hu H, Zhao X, Bao L, Huang D, Song L, Li Y. Mitochondrial GRIM-19 as a potential therapeutic target for STAT3-dependent carcinogenesis of gastric cancer. Oncotarget. 2016 Jul 5;7(27):41404-41420. doi: 10.18632/oncotarget.9167. PubMed PMID: 27167343; PubMed Central PMCID: PMC5173068.

59: Choi SA, Yun JW, Joo KM, Lee JY, Kwak PA, Lee YE, You JR, Kwon E, Kim WH, Wang KC, Phi JH, Kang BC, Kim SK. Preclinical Biosafety Evaluation of Genetically Modified Human Adipose Tissue-Derived Mesenchymal Stem Cells for Clinical Applications to Brainstem Glioma. Stem Cells Dev. 2016 Jun 15;25(12):897-908. doi: 10.1089/scd.2015.0324. Epub 2016 Jun 6. PubMed PMID: 27151205.

60: Karpel-Massler G, Horst BA, Shu C, Chau L, Tsujiuchi T, Bruce JN, Canoll P, Greene LA, Angelastro JM, Siegelin MD. A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers. Clin Cancer Res. 2016 Sep 15;22(18):4698-711. doi: 10.1158/1078-0432.CCR-15-2827. Epub 2016 Apr 28. PubMed PMID: 27126996; PubMed Central PMCID: PMC5026557.

61: Tang JH, Ma ZX, Huang GH, Xu QF, Xiang Y, Li N, Sidlauskas K, Zhang EE, Lv SQ. Downregulation of HIF-1a sensitizes U251 glioma cells to the temozolomide (TMZ) treatment. Exp Cell Res. 2016 May 1;343(2):148-158. doi: 10.1016/j.yexcr.2016.04.011. Epub 2016 Apr 21. PubMed PMID: 27090014.

62: Feng C, Luo T, Zhang S, Liu K, Zhang Y, Luo Y, Ge P. Lycopene protects human SH‑SY5Y neuroblastoma cells against hydrogen peroxide‑induced death via inhibition of oxidative stress and mitochondria‑associated apoptotic pathways. Mol Med Rep. 2016 May;13(5):4205-14. doi: 10.3892/mmr.2016.5056. Epub 2016 Mar 28. PubMed PMID: 27035331; PubMed Central PMCID: PMC4838073.

63: Wang S, Yin J, Ge M, Dai Z, Li Y, Si J, Ma K, Li L, Yao S. Transforming growth-beta 1 contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury by regulating the c-Jun N-terminal kinase signaling pathway. Biomed Pharmacother. 2016 Mar;78:280-290. doi: 10.1016/j.biopha.2016.01.030. Epub 2016 Feb 4. PubMed PMID: 26898453.

64: Zhao H, Wang C, Lu B, Zhou Z, Jin Y, Wang Z, Zheng L, Liu K, Luo T, Zhu D, Chi G, Luo Y, Ge P. Pristimerin triggers AIF-dependent programmed necrosis in glioma cells via activation of JNK. Cancer Lett. 2016 Apr 28;374(1):136-148. doi: 10.1016/j.canlet.2016.01.055. Epub 2016 Feb 17. PubMed PMID: 26854718.

65: Yang R, Yi L, Dong Z, Ouyang Q, Zhou J, Pang Y, Wu Y, Xu L, Cui H. Tigecycline Inhibits Glioma Growth by Regulating miRNA-199b-5p-HES1-AKT Pathway. Mol Cancer Ther. 2016 Mar;15(3):421-9. doi: 10.1158/1535-7163.MCT-15-0709. Epub 2016 Jan 28. PubMed PMID: 26823491.

66: Li H, Zheng J, Guan R, Zhu Z, Yuan X. Tyrphostin AG 1296 induces glioblastoma cell apoptosis in vitro and in vivo. Oncol Lett. 2015 Dec;10(6):3429-3433. Epub 2015 Oct 6. PubMed PMID: 26788146; PubMed Central PMCID: PMC4665272.

67: Cheng YC, Huang YC, Yeh TH, Shih HY, Lin CY, Lin SJ, Chiu CC, Huang CW, Jiang YJ. Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation. Neural Dev. 2015 Dec 30;10:28. doi: 10.1186/s13064-015-0055-5. PubMed PMID: 26714454; PubMed Central PMCID: PMC4696291.

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Chen W, Liu H, Wang T, Bao G, Wang N, Li RC. Downregulation of AIF-2 Inhibits Proliferation, Migration, and Invasion of Human Glioma Cells via Mitochondrial Dysfunction. J Mol Neurosci. 2019 Apr 13. doi: 10.1007/s12031-019-01306-y. [Epub ahead of print] PubMed PMID: 30982162.
apoptosis_inducing_factor.txt · Last modified: 2019/09/01 21:52 by administrador