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Beta catenin is a well-known crucial factor in astrocytoma progression and it is involved in aquaporin 1 (AQP1) mediated cell migration.

In a study, Zhang et al. revealed the function of AQP1 in astrocytoma progression and provided the first clinical evidence that AQP1 expression was positively correlated with β-catenin. Furthermore, they proved the functional role of AQP1/β-catenin pathway in astrocytoma progression. More importantly, they discovered that combination of AQP1 and β-catenin expression was an independent prognosis factor for astrocytoma patients and it was a better survival predictor than either AQP1 or β-catenin alone. In conclusion, the study provided a novel more precise prognostication for predicting astrocytoma prognosis based on combinatorial analysis of AQP1 and β-catenin expression 1).

Zhang H, Qin F, Yang L, He J, Liu X, Shao Y, Guo Z, Zhang M, Li W, Fu L, Gu F, Ma Y. Combination of AQP1 and β-catenin expression is an independent prognosis factor in astrocytoma patients. Oncotarget. 2017 Jul 26. doi: 10.18632/oncotarget.19562. [Epub ahead of print] PubMed PMID: 28767413.
aquaporin_1.txt · Last modified: 2017/08/03 12:35 by administrador