Astrocytic receptor

Astrogliosis in epileptic brain is a peculiar condition showing epileptogenesis and is thought to be different from the other pathological conditions. The aim of a study was to investigate the altered expression of astrocytic receptors, which contribute to neurotransmission in the synapse, and channels in hippocampal sclerosis (HS) lesions.

Aoki et al., performed immunohistochemical and immunoblotting analyses of the P2RY1, P2RY2, P2RY4, Kir4.1, Kv4.2, mGluR1, and mGluR5 receptors and channels with the brain samples of 20 HS patients and 4 controls and evaluated the ratio of immunopositive cells and those expression levels.

The ratio of each immunopositive cell per glial fibrillary acidic protein-positive astrocytes and the expression levels of all 7 astrocytic receptors and channels in HS lesions were significantly increased. We previously described unique astrogliosis in epileptic lesions similar to what was observed in this study.

This phenomenon is considered to trigger activation of the related signaling pathways and then contribute to epileptogenesis. Thus, astrocytes in epileptic lesion may show self-hyperexcitability and contribute to epileptogenesis through the endogenous astrocytic receptors and channels. These findings may suggest novel astrocytic receptor-related targets for the pharmacological treatment of epilepsy. 1).

2: Zhou X, Wu Q, Lu Y, Zhang X, Lv S, Shao J, Zhou Y, Chen J, Hou L, Huang C, Zhang X. A crosstalk between soluble PDGF-BB and PDGFRβ promotes astrocytic activation and synaptic recovery in the hippocampus after subarachnoid hemorrhage. FASEB J. 2019 Jun 4:fj201900195R. doi: 10.1096/fj.201900195R. [Epub ahead of print] PubMed PMID: 31162947.

3: Sun C, Zhao Y, Shi J, Zhang J, Yuan Y, Gu Y, Zhang F, Gao X, Wang C, Wang Y, Wang Z, Hu P, Qin J, Xiao L, Chang T, Wang L, Xi Y, Yin H, Chen H, Zhang L, Cheng G, Lin J, Zhang M, Li Z, Ye J. Isocitrate dehydrogenase1 mutation reduces the pericyte coverage of microvessels in astrocytic tumours. J Neurooncol. 2019 Apr 19. doi: 10.1007/s11060-019-03156-5. [Epub ahead of print] PubMed PMID: 31004262.

4: Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, Suk JS, Bergles DE, Haughey N, Pletnikov M, Hanes J, Rothstein JD. Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nat Neurosci. 2019 May;22(5):741-752. doi: 10.1038/s41593-019-0366-7. Epub 2019 Apr 1. PubMed PMID: 30936556.

5: de Vega S, Kondo A, Suzuki M, Arai H, Jiapaer S, Sabit H, Nakada M, Ikeuchi T, Ishijima M, Arikawa-Hirasawa E, Yamada Y, Okada Y. Fibulin-7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin-1. Int J Cancer. 2019 Mar 28. doi: 10.1002/ijc.32306. [Epub ahead of print] PubMed PMID: 30924128.

6: Zarb Y, Weber-Stadlbauer U, Kirschenbaum D, Kindler DR, Richetto J, Keller D, Rademakers R, Dickson DW, Pasch A, Byzova T, Nahar K, Voigt FF, Helmchen F, Boss A, Aguzzi A, Klohs J, Keller A. Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response. Brain. 2019 Apr 1;142(4):885-902. doi: 10.1093/brain/awz032. PubMed PMID: 30805583; PubMed Central PMCID: PMC6439320.

7: Contreras-Zárate MJ, Day NL, Ormond DR, Borges VF, Tobet S, Gril B, Steeg PS, Cittelly DM. Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases. Oncogene. 2019 Feb 22. doi: 10.1038/s41388-019-0756-z. [Epub ahead of print] PubMed PMID: 30796353.

8: Nozawa T, Okada M, Natsumeda M, Eda T, Abe H, Tsukamoto Y, Okamoto K, Oishi M, Takahashi H, Fujii Y, Kakita A. EGFRvIII Is Expressed in Cellular Areas of Tumor in a Subset of Glioblastoma. Neurol Med Chir (Tokyo). 2019 Mar 15;59(3):89-97. doi: 10.2176/nmc.oa.2018-0078. Epub 2019 Feb 21. PubMed PMID: 30787232; PubMed Central PMCID: PMC6434422.

9: Hu S, Wu G, Zheng J, Liu X, Zhang Y. Astrocytic thrombin-evoked VEGF release is dependent on p44/42 MAPKs and PAR1. Biochem Biophys Res Commun. 2019 Feb 5;509(2):585-589. doi: 10.1016/j.bbrc.2018.12.168. Epub 2018 Dec 31. PubMed PMID: 30606478.

10: Gril B, Paranjape AN, Woditschka S, Hua E, Dolan EL, Hanson J, Wu X, Kloc W, Izycka-Swieszewska E, Duchnowska R, Pęksa R, Biernat W, Jassem J, Nayyar N, Brastianos PK, Hall OM, Peer CJ, Figg WD, Pauly GT, Robinson C, Difilippantonio S, Bialecki E, Metellus P, Schneider JP, Steeg PS. Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases. Nat Commun. 2018 Jul 13;9(1):2705. doi: 10.1038/s41467-018-05030-w. PubMed PMID: 30006619; PubMed Central PMCID: PMC6045677.

11: Ratnam M, Chan J, Lesani N, Sidorova-Darmos E, Eubanks JH, Aarts MM. mRNA expression of transient receptor potential melastatin (TRPM) channels 2 and 7 in perinatal brain development. Int J Dev Neurosci. 2018 Oct;69:23-31. doi: 10.1016/j.ijdevneu.2018.05.008. Epub 2018 May 26. PubMed PMID: 29842890.

12: Lange F, Kaemmerer D, Behnke-Mursch J, Brück W, Schulz S, Lupp A. Differential somatostatin, CXCR4 chemokine and endothelin A receptor expression in WHO grade I-IV astrocytic brain tumors. J Cancer Res Clin Oncol. 2018 Jul;144(7):1227-1237. doi: 10.1007/s00432-018-2645-1. Epub 2018 Apr 25. PubMed PMID: 29696364.

13: Karnam S, Kottu R, Chowhan AK, Bodepati PC. Expression of p53 & epidermal growth factor receptor in glioblastoma. Indian J Med Res. 2017 Dec;146(6):738-745. doi: 10.4103/ijmr.IJMR_1179_15. PubMed PMID: 29664032; PubMed Central PMCID: PMC5926345.

14: Wang Q, Wang Z, Tian Y, Zhang H, Fang Y, Yu Z, Wang W, Xie M, Ding F. Inhibition of Astrocyte Connexin 43 Channels Facilitates the Differentiation of Oligodendrocyte Precursor Cells Under Hypoxic Conditions In Vitro. J Mol Neurosci. 2018 Apr;64(4):591-600. doi: 10.1007/s12031-018-1061-y. Epub 2018 Apr 5. PubMed PMID: 29623602.

15: Xiong Y, Teng S, Zheng L, Sun S, Li J, Guo N, Li M, Wang L, Zhu F, Wang C, Rao Z, Zhou Z. Stretch-induced Ca(2+) independent ATP release in hippocampal astrocytes. J Physiol. 2018 May 15;596(10):1931-1947. doi: 10.1113/JP275805. Epub 2018 Apr 6. PubMed PMID: 29488635; PubMed Central PMCID: PMC5978314.

16: Rose CR, Felix L, Zeug A, Dietrich D, Reiner A, Henneberger C. Astroglial Glutamate Signaling and Uptake in the Hippocampus. Front Mol Neurosci. 2018 Jan 17;10:451. doi: 10.3389/fnmol.2017.00451. eCollection 2017. Review. PubMed PMID: 29386994; PubMed Central PMCID: PMC5776105.

17: Lan YL, Zou S, Wang X, Lou JC, Xing JS, Yu M, Zhang B. Update on the therapeutic significance of estrogen receptor beta in malignant gliomas. Oncotarget. 2017 Sep 18;8(46):81686-81696. doi: 10.18632/oncotarget.20970. eCollection 2017 Oct 6. Review. PubMed PMID: 29113424; PubMed Central PMCID: PMC5655319.

18: Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 6;96(5):1003-1012.e7. doi: 10.1016/j.neuron.2017.10.008. Epub 2017 Nov 2. PubMed PMID: 29103804; PubMed Central PMCID: PMC5851281.

19: Sinha B, Wu Q, Li W, Tu Y, Sirianni AC, Chen Y, Jiang J, Zhang X, Chen W, Zhou S, Reiter RJ, Manning SM, Patel NJ, Aziz-Sultan AM, Inder TE, Friedlander RM, Fu J, Wang X. Protection of melatonin in experimental models of newborn hypoxic-ischemic brain injury through MT1 receptor. J Pineal Res. 2018 Jan;64(1). doi: 10.1111/jpi.12443. Epub 2017 Oct 23. PubMed PMID: 28796402.

20: Zhao ZA, Li P, Ye SY, Ning YL, Wang H, Peng Y, Yang N, Zhao Y, Zhang ZH, Chen JF, Zhou YG. Perivascular AQP4 dysregulation in the hippocampal CA1 area after traumatic brain injury is alleviated by adenosine A(2A) receptor inactivation. Sci Rep. 2017 May 22;7(1):2254. doi: 10.1038/s41598-017-02505-6. PubMed PMID: 28533515; PubMed Central PMCID: PMC5440401.

21: Weller M, Roth P, Preusser M, Wick W, Reardon DA, Platten M, Sampson JH. Vaccine-based immunotherapeutic approaches to gliomas and beyond. Nat Rev Neurol. 2017 Jun;13(6):363-374. doi: 10.1038/nrneurol.2017.64. Epub 2017 May 12. Review. PubMed PMID: 28497804.

22: Sharma V, Malgulwar PB, Purkait S, Patil V, Pathak P, Agrawal R, Kulshreshtha R, Mallick S, Julka PK, Suri A, Sharma BS, Suri V, Sharma MC, Sarkar C. Genome-wide ChIP-seq analysis of EZH2-mediated H3K27me3 target gene profile highlights differences between low- and high-grade astrocytic tumors. Carcinogenesis. 2017 Feb 1;38(2):152-161. doi: 10.1093/carcin/bgw126. PubMed PMID: 27993893.

23: Zhai X, Liang P, Li Y, Li L, Zhou Y, Wu X, Deng J, Jiang L. Astrocytes Regulate Angiogenesis Through the Jagged1-Mediated Notch1 Pathway After Status Epilepticus. Mol Neurobiol. 2016 Nov;53(9):5893-5901. doi: 10.1007/s12035-015-9492-8. Epub 2015 Oct 27. PubMed PMID: 26507745.

24: Qiu J, Wang M, Zhang J, Cai Q, Lu D, Li Y, Dong Y, Zhao T, Chen H. The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling. Int Immunopharmacol. 2016 Nov;40:492-500. doi: 10.1016/j.intimp.2016.09.024. Epub 2016 Oct 18. PubMed PMID: 27769021.

25: Qiu J, Yan Z, Tao K, Li Y, Li Y, Li J, Dong Y, Feng D, Chen H. Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice. J Neuroinflammation. 2016 Oct 10;13(1):263. PubMed PMID: 27724964; PubMed Central PMCID: PMC5057372.

26: Noristani HN, Sabourin JC, Boukhaddaoui H, Chan-Seng E, Gerber YN, Perrin FE. Spinal cord injury induces astroglial conversion towards neuronal lineage. Mol Neurodegener. 2016 Oct 6;11(1):68. PubMed PMID: 27716282; PubMed Central PMCID: PMC5052929.

27: Li YX, Shi Z, Aibaidula A, Chen H, Tang Q, Li KK, Chung NY, Chan DT, Poon WS, Mao Y, Wu J, Zhou L, Chan AK, Ng HK. Not all 1p/19q non-codeleted oligodendroglial tumors are astrocytic. Oncotarget. 2016 Oct 4;7(40):64615-64630. doi: 10.18632/oncotarget.11378. PubMed PMID: 27556304; PubMed Central PMCID: PMC5323103.

28: Busek P, Balaziova E, Matrasova I, Hilser M, Tomas R, Syrucek M, Zemanova Z, Krepela E, Belacek J, Sedo A. Fibroblast activation protein alpha is expressed by transformed and stromal cells and is associated with mesenchymal features in glioblastoma. Tumour Biol. 2016 Oct;37(10):13961-13971. Epub 2016 Aug 4. PubMed PMID: 27492457.

29: Niehusmann P, Widman G, Eis-Hübinger AM, Greschus S, Robens BK, Grote A, Becker AJ. Non-paraneoplastic limbic encephalitis and central nervous HHV-6B reactivation: Causality or coincidence? Neuropathology. 2016 Aug;36(4):376-80. doi: 10.1111/neup.12283. Epub 2016 Jan 15. PubMed PMID: 27431532.

30: Guo JG, Guo CC, He ZQ, Liu ZG, Wang Y, Mou YG. Clinical significance of B7-H6 protein expression in astrocytoma. Onco Targets Ther. 2016 May 31;9:3291-7. doi: 10.2147/OTT.S103771. eCollection 2016. PubMed PMID: 27330308; PubMed Central PMCID: PMC4898414.

31: Amegandjin CA, Jammow W, Laforest S, Riad M, Baharnoori M, Badeaux F, DesGroseillers L, Murai KK, Pasquale EB, Drolet G, Doucet G. Regional expression and ultrastructural localization of EphA7 in the hippocampus and cerebellum of adult rat. J Comp Neurol. 2016 Aug 15;524(12):2462-78. doi: 10.1002/cne.23962. Epub 2016 Feb 26. PubMed PMID: 26780036.

32: Risher ML, Sexton HG, Risher WC, Wilson WA, Fleming RL, Madison RD, Moore SD, Eroglu C, Swartzwelder HS. Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus. Alcohol Clin Exp Res. 2015 Dec;39(12):2403-13. doi: 10.1111/acer.12913. Epub 2015 Nov 5. Erratum in: Alcohol Clin Exp Res. 2016 Aug;40(8):1794. PubMed PMID: 26537975; PubMed Central PMCID: PMC4712076.

33: Herrlinger U, Jones DTW, Glas M, Hattingen E, Gramatzki D, Stuplich M, Felsberg J, Bähr O, Gielen GH, Simon M, Wiewrodt D, Schabet M, Hovestadt V, Capper D, Steinbach JP, von Deimling A, Lichter P, Pfister SM, Weller M, Reifenberger G. Gliomatosis cerebri: no evidence for a separate brain tumor entity. Acta Neuropathol. 2016 Feb;131(2):309-319. doi: 10.1007/s00401-015-1495-z. Epub 2015 Oct 22. Erratum in: Acta Neuropathol. 2016 Feb;131(2):321-2. PubMed PMID: 26493382.

34: Ding S, Wang W, Wang X, Liang Y, Liu L, Ye Y, Yang J, Gao H, Zhuge Q. Dopamine Burden Triggers Neurodegeneration via Production and Release of TNF-α from Astrocytes in Minimal Hepatic Encephalopathy. Mol Neurobiol. 2016 Oct;53(8):5324-43. doi: 10.1007/s12035-015-9445-2. Epub 2015 Oct 3. PubMed PMID: 26433377.

35: Ghosh M, Balbi M, Hellal F, Dichgans M, Lindauer U, Plesnila N. Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Ann Neurol. 2015 Dec;78(6):887-900. doi: 10.1002/ana.24512. Epub 2015 Oct 7. PubMed PMID: 26312599.

36: Mao K, You C, Lei D, Zhang H. High dosage of cannabidiol (CBD) alleviates pentylenetetrazole-induced epilepsy in rats by exerting an anticonvulsive effect. Int J Clin Exp Med. 2015 Jun 15;8(6):8820-7. eCollection 2015. PubMed PMID: 26309534; PubMed Central PMCID: PMC4537971.

37: Chen WF, Chen CH, Chen NF, Sung CS, Wen ZH. Neuroprotective Effects of Direct Intrathecal Administration of Granulocyte Colony-Stimulating Factor in Rats with Spinal Cord Injury. CNS Neurosci Ther. 2015 Sep;21(9):698-707. doi: 10.1111/cns.12429. Epub 2015 Jul 20. PubMed PMID: 26190345.

38: Nordfors K, Haapasalo J, Mäkelä K, Granberg KJ, Nykter M, Korja M, Paavonen T, Haapasalo H, Soini Y. Twist predicts poor outcome of patients with astrocytic glioma. J Clin Pathol. 2015 Nov;68(11):905-12. doi: 10.1136/jclinpath-2015-202868. Epub 2015 Jul 10. PubMed PMID: 26163539.

39: Sun L, Gao J, Zhao M, Cui J, Li Y, Yang X, Jing X, Wu Z. A novel cognitive impairment mechanism that astrocytic p-connexin 43 promotes neuronic autophagy via activation of P2X7R and down-regulation of GLT-1 expression in the hippocampus following traumatic brain injury in rats. Behav Brain Res. 2015 Sep 15;291:315-324. doi: 10.1016/j.bbr.2015.05.049. Epub 2015 May 29. PubMed PMID: 26031379.

40: Olsen TK, Panagopoulos I, Meling TR, Micci F, Gorunova L, Thorsen J, Due-Tønnessen B, Scheie D, Lund-Iversen M, Krossnes B, Saxhaug C, Heim S, Brandal P. Fusion genes with ALK as recurrent partner in ependymoma-like gliomas: a new brain tumor entity? Neuro Oncol. 2015 Oct;17(10):1365-73. doi: 10.1093/neuonc/nov039. Epub 2015 Mar 19. PubMed PMID: 25795305; PubMed Central PMCID: PMC4578580.

41: Morzaev D, Nicholson JD, Caspi T, Weiss S, Hochhauser E, Goldenberg-Cohen N. Toll-like receptor-4 knockout mice are more resistant to optic nerve crush damage than wild-type mice. Clin Exp Ophthalmol. 2015 Sep-Oct;43(7):655-65. doi: 10.1111/ceo.12521. Epub 2015 May 13. PubMed PMID: 25752496.

42: Caffes N, Kurland DB, Gerzanich V, Simard JM. Glibenclamide for the treatment of ischemic and hemorrhagic stroke. Int J Mol Sci. 2015 Mar 4;16(3):4973-84. doi: 10.3390/ijms16034973. Review. PubMed PMID: 25749474; PubMed Central PMCID: PMC4394459.

43: Hirayama Y, Ikeda-Matsuo Y, Notomi S, Enaida H, Kinouchi H, Koizumi S. Astrocyte-mediated ischemic tolerance. J Neurosci. 2015 Mar 4;35(9):3794-805. doi: 10.1523/JNEUROSCI.4218-14.2015. PubMed PMID: 25740510.

44: Tang W, Szokol K, Jensen V, Enger R, Trivedi CA, Hvalby Ø, Helm PJ, Looger LL, Sprengel R, Nagelhus EA. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci. 2015 Feb 18;35(7):3016-21. doi: 10.1523/JNEUROSCI.3319-14.2015. PubMed PMID: 25698739; PubMed Central PMCID: PMC4331625.

45: Crosby ND, Zaucke F, Kras JV, Dong L, Luo ZD, Winkelstein BA. Thrombospondin-4 and excitatory synaptogenesis promote spinal sensitization after painful mechanical joint injury. Exp Neurol. 2015 Feb;264:111-20. doi: 10.1016/j.expneurol.2014.11.015. Epub 2014 Dec 5. PubMed PMID: 25483397; PubMed Central PMCID: PMC4324021.

46: Saha R, Chatterjee U, Mandal S, Saha K, Chatterjee S, Ghosh SN. Expression of phosphatase and tensin homolog, epidermal growth factor receptor, and Ki-67 in astrocytoma: A prospective study in a tertiary care hospital. Indian J Med Paediatr Oncol. 2014 Apr;35(2):149-55. doi: 10.4103/0971-5851.138983. PubMed PMID: 25197177; PubMed Central PMCID: PMC4152632.

47: Papadopoulos MC, Bennett JL, Verkman AS. Treatment of neuromyelitis optica: state-of-the-art and emerging therapies. Nat Rev Neurol. 2014 Sep;10(9):493-506. doi: 10.1038/nrneurol.2014.141. Epub 2014 Aug 12. Review. PubMed PMID: 25112508; PubMed Central PMCID: PMC4229040.

48: Israelsson C, Flygt J, Åstrand E, Kiwanuka O, Bengtsson H, Marklund N. Altered expression of myelin-associated inhibitors and their receptors after traumatic brain injury in the mouse. Restor Neurol Neurosci. 2014;32(5):717-31. doi: 10.3233/RNN-140419. PubMed PMID: 25079982.

49: Chen T, Hou R, Li C, Wu C, Xu S. MPTP/MPP+ suppresses activation of protein C in Parkinson's disease. J Alzheimers Dis. 2015;43(1):133-42. doi: 10.3233/JAD-140126. PubMed PMID: 25061051.

50: Liang J, Chao D, Sandhu HK, Yu Y, Zhang L, Balboni G, Kim DH, Xia Y. δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes. Br J Pharmacol. 2014 Dec;171(23):5417-30. doi: 10.1111/bph.12857. PubMed PMID: 25052197; PubMed Central PMCID: PMC4294049.

51: Bernardinelli Y, Randall J, Janett E, Nikonenko I, König S, Jones EV, Flores CE, Murai KK, Bochet CG, Holtmaat A, Muller D. Activity-dependent structural plasticity of perisynaptic astrocytic domains promotes excitatory synapse stability. Curr Biol. 2014 Aug 4;24(15):1679-88. doi: 10.1016/j.cub.2014.06.025. Epub 2014 Jul 17. PubMed PMID: 25042585.

52: Marmarou CR, Liang X, Abidi NH, Parveen S, Taya K, Henderson SC, Young HF, Filippidis AS, Baumgarten CM. Selective vasopressin-1a receptor antagonist prevents brain edema, reduces astrocytic cell swelling and GFAP, V1aR and AQP4 expression after focal traumatic brain injury. Brain Res. 2014 Sep 18;1581:89-102. doi: 10.1016/j.brainres.2014.06.005. Epub 2014 Jun 13. PubMed PMID: 24933327; PubMed Central PMCID: PMC4240002.

53: Flaisher-Grinberg S, Tsai HC, Feng X, Wei LN. Emotional regulatory function of receptor interacting protein 140 revealed in the ventromedial hypothalamus. Brain Behav Immun. 2014 Aug;40:226-34. doi: 10.1016/j.bbi.2014.03.019. Epub 2014 Apr 13. PubMed PMID: 24726835; PubMed Central PMCID: PMC4102625.

54: Filippidis AS, Liang X, Wang W, Parveen S, Baumgarten CM, Marmarou CR. Real-time monitoring of changes in brain extracellular sodium and potassium concentrations and intracranial pressure after selective vasopressin-1a receptor inhibition following focal traumatic brain injury in rats. J Neurotrauma. 2014 Jul 15;31(14):1258-67. doi: 10.1089/neu.2013.3063. Epub 2014 May 28. PubMed PMID: 24635833; PubMed Central PMCID: PMC4108937.

55: Li L, Xiong ZY, Qian ZM, Zhao TZ, Feng H, Hu S, Hu R, Ke Y, Lin J. Complement C5a is detrimental to histological and functional locomotor recovery after spinal cord injury in mice. Neurobiol Dis. 2014 Jun;66:74-82. doi: 10.1016/j.nbd.2014.02.008. Epub 2014 Mar 6. PubMed PMID: 24607885.

56: Robson MJ, Turner RC, Naser ZJ, McCurdy CR, O'Callaghan JP, Huber JD, Matsumoto RR. SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation. Exp Neurol. 2014 Apr;254:180-9. doi: 10.1016/j.expneurol.2014.01.020. Epub 2014 Feb 6. PubMed PMID: 24508558; PubMed Central PMCID: PMC4241368.

57: Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL. Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells. Mol Med. 2013 Nov 8;19:399-408. doi: 10.2119/molmed.2013.00136. PubMed PMID: 24408113; PubMed Central PMCID: PMC3883967.

58: Weisshaar CL, Winkelstein BA. Ablating spinal NK1-bearing neurons eliminates the development of pain and reduces spinal neuronal hyperexcitability and inflammation from mechanical joint injury in the rat. J Pain. 2014 Apr;15(4):378-86. doi: 10.1016/j.jpain.2013.12.003. Epub 2014 Jan 2. PubMed PMID: 24389017; PubMed Central PMCID: PMC3972292.

59: Laird MD, Shields JS, Sukumari-Ramesh S, Kimbler DE, Fessler RD, Shakir B, Youssef P, Yanasak N, Vender JR, Dhandapani KM. High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4. Glia. 2014 Jan;62(1):26-38. doi: 10.1002/glia.22581. Epub 2013 Oct 28. PubMed PMID: 24166800; PubMed Central PMCID: PMC4503251.

60: Ding F, O'Donnell J, Thrane AS, Zeppenfeld D, Kang H, Xie L, Wang F, Nedergaard M. α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice. Cell Calcium. 2013 Dec;54(6):387-94. doi: 10.1016/j.ceca.2013.09.001. Epub 2013 Sep 24. PubMed PMID: 24138901; PubMed Central PMCID: PMC3858490.

61: Johansson JU, Pradhan S, Lokteva LA, Woodling NS, Ko N, Brown HD, Wang Q, Loh C, Cekanaviciute E, Buckwalter M, Manning-Bog AB, Andreasson KI. Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia. J Neurosci. 2013 Oct 2;33(40):16016-32. doi: 10.1523/JNEUROSCI.2203-13.2013. PubMed PMID: 24089506; PubMed Central PMCID: PMC3787507.

62: Kuric E, Wieloch T, Ruscher K. Dopamine receptor activation increases glial cell line-derived neurotrophic factor in experimental stroke. Exp Neurol. 2013 Sep;247:202-8. doi: 10.1016/j.expneurol.2013.04.016. Epub 2013 May 9. PubMed PMID: 23664961.

63: Ji XT, Qian NS, Zhang T, Li JM, Li XK, Wang P, Zhao DS, Huang G, Zhang L, Fei Z, Jia D, Niu L. Spinal astrocytic activation contributes to mechanical allodynia in a rat chemotherapy-induced neuropathic pain model. PLoS One. 2013 Apr 9;8(4):e60733. doi: 10.1371/journal.pone.0060733. Print 2013. PubMed PMID: 23585846; PubMed Central PMCID: PMC3621957.

64: Tei N, Tanaka J, Sugimoto K, Nishihara T, Nishioka R, Takahashi H, Yano H, Matsumoto S, Ohue S, Watanabe H, Kumon Y, Ohnishi T. Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions. J Neurosci Res. 2013 May;91(5):681-93. doi: 10.1002/jnr.23202. Epub 2013 Feb 12. PubMed PMID: 23400803.

65: Xu P, Zhang A, Jiang R, Qiu M, Kang C, Jia Z, Wang G, Han L, Fan X, Pu P. The different role of Notch1 and Notch2 in astrocytic gliomas. PLoS One. 2013;8(1):e53654. doi: 10.1371/journal.pone.0053654. Epub 2013 Jan 21. PubMed PMID: 23349727; PubMed Central PMCID: PMC3549979.

66: Mao F, Wang B, Xiao Q, Xi G, Sun W, Zhang H, Ye F, Wan F, Guo D, Lei T, Chen X. A role for LRIG1 in the regulation of malignant glioma aggressiveness. Int J Oncol. 2013 Mar;42(3):1081-7. doi: 10.3892/ijo.2013.1776. Epub 2013 Jan 16. PubMed PMID: 23337938.

67: Zhou S, Wu H, Zeng C, Xiong X, Tang S, Tang Z, Sun X. Apolipoprotein E protects astrocytes from hypoxia and glutamate-induced apoptosis. FEBS Lett. 2013 Jan 16;587(2):254-8. doi: 10.1016/j.febslet.2012.12.003. Epub 2012 Dec 10. PubMed PMID: 23238080.

68: Kasseckert SA, Shahzad T, Miqdad M, Stein M, Abdallah Y, Scharbrodt W, Oertel M. The mechanisms of energy crisis in human astrocytes after subarachnoid hemorrhage. Neurosurgery. 2013 Mar;72(3):468-74; discussion 474. doi: 10.1227/NEU.0b013e31827d0de7. PubMed PMID: 23151619.

69: Yamada J, Jinno S. Upregulation of calcium binding protein, S100A6, in activated astrocytes is linked to glutamate toxicity. Neuroscience. 2012 Dec 13;226:119-29. doi: 10.1016/j.neuroscience.2012.08.068. Epub 2012 Sep 12. PubMed PMID: 22982625.

70: Kimbler DE, Shields J, Yanasak N, Vender JR, Dhandapani KM. Activation of P2X7 promotes cerebral edema and neurological injury after traumatic brain injury in mice. PLoS One. 2012;7(7):e41229. doi: 10.1371/journal.pone.0041229. Epub 2012 Jul 17. PubMed PMID: 22815977; PubMed Central PMCID: PMC3398891.

71: Yu SX, Li S, Shu HF, Zhang CQ, Liu SY, Yang H. Expression of the Nogo-A system in cortical lesions of pediatric patients with tuberous sclerosis complex and focal cortical dysplasia type IIb. J Neuropathol Exp Neurol. 2012 Jul;71(7):665-77. doi: 10.1097/NEN.0b013e31825d6585. PubMed PMID: 22710967.

72: Shu HF, Yu SX, Zhang CQ, Liu SY, Wu KF, Zang ZL, Yang H, Zhou SW, Yin Q. Expression of TRPV1 in cortical lesions from patients with tuberous sclerosis complex and focal cortical dysplasia type IIb. Brain Dev. 2013 Mar;35(3):252-60. doi: 10.1016/j.braindev.2012.04.007. Epub 2012 May 28. PubMed PMID: 22647236.

73: Kouri FM, Jensen SA, Stegh AH. The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond. ScientificWorldJournal. 2012;2012:838916. doi: 10.1100/2012/838916. Epub 2012 Feb 14. Review. PubMed PMID: 22431925; PubMed Central PMCID: PMC3289992.

74: Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M. Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6265-70. doi: 10.1073/pnas.1120997109. Epub 2012 Mar 15. PubMed PMID: 22421436; PubMed Central PMCID: PMC3341061.

75: Zhai J, Zhou W, Li J, Hayworth CR, Zhang L, Misawa H, Klein R, Scherer SS, Balice-Gordon RJ, Kalb RG. The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease. Hum Mol Genet. 2011 Nov 1;20(21):4116-31. doi: 10.1093/hmg/ddr335. Epub 2011 Aug 4. PubMed PMID: 21816949; PubMed Central PMCID: PMC3218642.

76: Campos B, Bermejo JL, Han L, Felsberg J, Ahmadi R, Grabe N, Reifenberger G, Unterberg A, Herold-Mende C. Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas. Cancer Sci. 2011 Feb;102(2):387-92. doi: 10.1111/j.1349-7006.2010.01792.x. Epub 2010 Dec 10. PubMed PMID: 21143702.

77: Jha P, Suri V, Jain A, Sharma MC, Pathak P, Jha P, Srivastava A, Suri A, Gupta D, Chosdol K, Chattopadhyay P, Sarkar C. O6-methylguanine DNA methyltransferase gene promoter methylation status in gliomas and its correlation with other molecular alterations: first Indian report with review of challenges for use in customized treatment. Neurosurgery. 2010 Dec;67(6):1681-91. doi: 10.1227/NEU.0b013e3181f743f5. Review. PubMed PMID: 21107199.

78: Weisshaar CL, Dong L, Bowman AS, Perez FM, Guarino BB, Sweitzer SM, Winkelstein BA. Metabotropic glutamate receptor-5 and protein kinase C-epsilon increase in dorsal root ganglion neurons and spinal glial activation in an adolescent rat model of painful neck injury. J Neurotrauma. 2010 Dec;27(12):2261-71. doi: 10.1089/neu.2010.1460. PubMed PMID: 20925479.

79: Kaneko N, Marín O, Koike M, Hirota Y, Uchiyama Y, Wu JY, Lu Q, Tessier-Lavigne M, Alvarez-Buylla A, Okano H, Rubenstein JL, Sawamoto K. New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron. 2010 Jul 29;67(2):213-23. doi: 10.1016/j.neuron.2010.06.018. PubMed PMID: 20670830; PubMed Central PMCID: PMC4080818.

80: Shu HF, Zhang CQ, Yin Q, An N, Liu SY, Yang H. Expression of the interleukin 6 system in cortical lesions from patients with tuberous sclerosis complex and focal cortical dysplasia type IIb. J Neuropathol Exp Neurol. 2010 Aug;69(8):838-49. doi: 10.1097/NEN.0b013e3181eaeae5. PubMed PMID: 20613633.

81: Zhu L, Lu J, Tay SS, Jiang H, He BP. Induced NG2 expressing microglia in the facial motor nucleus after facial nerve axotomy. Neuroscience. 2010 Mar 31;166(3):842-51. doi: 10.1016/j.neuroscience.2009.12.057. Epub 2010 Jan 6. PubMed PMID: 20060036.

82: Wainwright DA, Xin J, Mesnard NA, Sanders VM, Jones KJ. Toll-like receptor 2 and facial motoneuron survival after facial nerve axotomy. Neurosci Lett. 2010 Feb 26;471(1):10-4. doi: 10.1016/j.neulet.2009.12.076. Epub 2010 Jan 5. PubMed PMID: 20056129; PubMed Central PMCID: PMC2825370.

83: Xu P, Qiu M, Zhang Z, Kang C, Jiang R, Jia Z, Wang G, Jiang H, Pu P. The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo. J Neurooncol. 2010 Mar;97(1):41-51. doi: 10.1007/s11060-009-0007-1. Epub 2009 Sep 22. PubMed PMID: 19771395.

84: Hayashi S, Yamamoto M, Tachibana K, Ueno Y, Bu G, Fukushima T. Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death. Anticancer Res. 2009 Mar;29(3):897-905. PubMed PMID: 19414325.

85: Zhang H, Xie M, Schools GP, Feustel PF, Wang W, Lei T, Kimelberg HK, Zhou M. Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model. Brain Res. 2009 Jan 9;1247:196-211. doi: 10.1016/j.brainres.2008.10.015. Epub 2008 Nov 1. PubMed PMID: 18992727; PubMed Central PMCID: PMC2649761.

86: Hoang S, Liauw J, Choi M, Choi M, Guzman RG, Steinberg GK. Netrin-4 enhances angiogenesis and neurologic outcome after cerebral ischemia. J Cereb Blood Flow Metab. 2009 Feb;29(2):385-97. doi: 10.1038/jcbfm.2008.128. Epub 2008 Nov 5. PubMed PMID: 18985053.

87: Miwa T, Hirose Y, Sasaki H, Ikeda E, Yoshida K, Kawase T. Genetic characterization of adult infratentorial gliomas. J Neurooncol. 2009 Feb;91(3):251-5. doi: 10.1007/s11060-008-9714-2. Epub 2008 Oct 22. PubMed PMID: 18941867.

88: Wang X, Takano T, Nedergaard M. Astrocytic calcium signaling: mechanism and implications for functional brain imaging. Methods Mol Biol. 2009;489:93-109. doi: 10.1007/978-1-59745-543-5_5. Review. PubMed PMID: 18839089; PubMed Central PMCID: PMC3638986.

89: Hummel M, Strassle B, Miller S, Kaftan E, Whiteside G. Anatomical localization and expression pattern for the NMDA-2D receptor subunit in a rat model of neuropathic pain. Neuroscience. 2008 Aug 13;155(2):492-502. doi: 10.1016/j.neuroscience.2008.05.041. Epub 2008 Jun 5. PubMed PMID: 18585442.

90: Bekar LK, He W, Nedergaard M. Locus coeruleus alpha-adrenergic-mediated activation of cortical astrocytes in vivo. Cereb Cortex. 2008 Dec;18(12):2789-95. doi: 10.1093/cercor/bhn040. Epub 2008 Mar 27. PubMed PMID: 18372288; PubMed Central PMCID: PMC2583159.

91: Taya K, Gulsen S, Okuno K, Prieto R, Marmarou CR, Marmarou A. Modulation of AQP4 expression by the selective V1a receptor antagonist, SR49059, decreases trauma-induced brain edema. Acta Neurochir Suppl. 2008;102:425-9. PubMed PMID: 19388360.

92: Li X, Wang Y, Wang Y, Zhen H, Yang H, Fei Z, Zhang J, Liu W, Wang Y, Zhang X. Expression of EphA2 in human astrocytic tumors: correlation with pathologic grade, proliferation and apoptosis. Tumour Biol. 2007;28(3):165-72. Epub 2007 May 21. PubMed PMID: 17519535.

93: Dong L, Pu PY, Wang H, Wang GX, Kang CS, Jiao DR. [Study on the expression of epidermal growth factor receptor and p53 in astrocytic gliomas: evidence for a distinct genetic pathway]. Zhonghua Bing Li Xue Za Zhi. 2006 Apr;35(4):232-6. Chinese. PubMed PMID: 16776982.

94: Pu P, Kang C, Zhang Z, Liu X, Jiang H. Downregulation of PIK3CB by siRNA suppresses malignant glioma cell growth in vitro and in vivo. Technol Cancer Res Treat. 2006 Jun;5(3):271-80. PubMed PMID: 16700623.

95: Wang X, Lou N, Xu Q, Tian GF, Peng WG, Han X, Kang J, Takano T, Nedergaard M. Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo. Nat Neurosci. 2006 Jun;9(6):816-23. Epub 2006 May 14. PubMed PMID: 16699507.

96: Wang L, Fortune B, Cull G, Dong J, Cioffi GA. Endothelin B receptor in human glaucoma and experimentally induced optic nerve damage. Arch Ophthalmol. 2006 May;124(5):717-24. PubMed PMID: 16682595.

97: Rappold PM, Lynd-Balta E, Joseph SA. P2X7 receptor immunoreactive profile confined to resting and activated microglia in the epileptic brain. Brain Res. 2006 May 17;1089(1):171-8. Epub 2006 Apr 25. PubMed PMID: 16635480.

98: Kuijlen JM, Mooij JJ, Platteel I, Hoving EW, van der Graaf WT, Span MM, Hollema H, den Dunnen WF. TRAIL-receptor expression is an independent prognostic factor for survival in patients with a primary glioblastoma multiforme. J Neurooncol. 2006 Jun;78(2):161-71. Epub 2006 Mar 17. PubMed PMID: 16544055.

99: Huang H, Held-Feindt J, Buhl R, Mehdorn HM, Mentlein R. Expression of VEGF and its receptors in different brain tumors. Neurol Res. 2005 Jun;27(4):371-7. PubMed PMID: 15949234.

100: Arakawa Y, Tachibana O, Hasegawa M, Miyamori T, Yamashita J, Hayashi Y. Frequent gene amplification and overexpression of decoy receptor 3 in glioblastoma. Acta Neuropathol. 2005 Mar;109(3):294-8. Epub 2004 Dec 31. PubMed PMID: 15627206.

101: Bursztajn S, Rutkowski MD, Deleo JA. The role of the N-methyl-D-aspartate receptor NR1 subunit in peripheral nerve injury-induced mechanical allodynia, glial activation and chemokine expression in the mouse. Neuroscience. 2004;125(1):269-75. PubMed PMID: 15051165.

102: Eid T, Brines ML, Cerami A, Spencer DD, Kim JH, Schweitzer JS, Ottersen OP, de Lanerolle NC. Increased expression of erythropoietin receptor on blood vessels in the human epileptogenic hippocampus with sclerosis. J Neuropathol Exp Neurol. 2004 Jan;63(1):73-83. PubMed PMID: 14748563.

103: Benes L, Kappus C, McGregor GP, Bertalanffy H, Mennel HD, Hagner S. The immunohistochemical expression of calcitonin receptor-like receptor (CRLR) in human gliomas. J Clin Pathol. 2004 Feb;57(2):172-6. PubMed PMID: 14747444; PubMed Central PMCID: PMC1770218.

104: Ulbricht U, Brockmann MA, Aigner A, Eckerich C, Müller S, Fillbrandt R, Westphal M, Lamszus K. Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas. J Neuropathol Exp Neurol. 2003 Dec;62(12):1265-75. PubMed PMID: 14692702.

105: Hai J, Li ST, Lin Q, Pan QG, Gao F, Ding MX. Vascular endothelial growth factor expression and angiogenesis induced by chronic cerebral hypoperfusion in rat brain. Neurosurgery. 2003 Oct;53(4):963-70; discussion 970-2. PubMed PMID: 14519228.

106: Fukui S, Nawashiro H, Otani N, Ooigawa H, Nomura N, Yano A, Miyazawa T, Ohnuki A, Tsuzuki N, Katoh H, Ishihara S, Shima K. Nuclear accumulation of basic fibroblast growth factor in human astrocytic tumors. Cancer. 2003 Jun 15;97(12):3061-7. PubMed PMID: 12784342.

107: Sarret P, Perron A, Stroh T, Beaudet A. Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous system. J Comp Neurol. 2003 Jul 7;461(4):520-38. PubMed PMID: 12746866.

108: Yamaguchi F, Morrison RS, Gonatas NK, Takahashi H, Sugisaki Y, Teramoto A. Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: an index of malignancy in astrocytomas. Int J Oncol. 2003 May;22(5):1045-9. PubMed PMID: 12684670.

109: Lefranc F, Sadeghi N, Metens T, Brotchi J, Salmon I, Kiss R. Characterization of gastrin-induced cytostatic effect on cell proliferation in experimental malignant gliomas. Neurosurgery. 2003 Apr;52(4):881-90; discussion 890-1. PubMed PMID: 12657185.

110: Kajiwara Y, Yamasaki F, Hama S, Yahara K, Yoshioka H, Sugiyama K, Arita K, Kurisu K. Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosis. Cancer. 2003 Feb 15;97(4):1077-83. PubMed PMID: 12569609.

111: Fujita H, Koji T, Kitagawa N, Tsutsumi K, Abe K, Kaminogo M, Shibata S. Possible involvement of Fas system in the induction of apoptosis in human astrocytic brain tumors. Cell Mol Neurobiol. 2002 Aug;22(4):393-406. PubMed PMID: 12507389.

112: Lefranc F, Chaboteaux C, Belot N, Brotchi J, Salmon I, Kiss R. Determination of RNA expression for cholecystokinin/gastrin receptors (CCKA, CCKB and CCKC) in human tumors of the central and peripheral nervous system. Int J Oncol. 2003 Jan;22(1):213-9. PubMed PMID: 12469207.

113: Lefranc F, Camby I, Belot N, Bruyneel E, Chaboteaux C, Brotchi J, Mareel M, Salmon I, Kiss R. Gastrin significantly modifies the migratory abilities of experimental glioma cells. Lab Invest. 2002 Sep;82(9):1241-52. PubMed PMID: 12218085.

114: Holmin S, Mathiesen T, Langmoen IA, Sandberg Nordqvist AC. Depolarization induces insulin-like growth factor binding protein-2 expression in vivo via NMDA receptor stimulation. Growth Horm IGF Res. 2001 Dec;11(6):399-406. PubMed PMID: 11914028.

115: Tanaka S, Kobayashi I, Oka H, Fujii K, Watanabe T, Nagashima T, Hori T. Drug-resistance gene expression and progression of astrocytic tumors. Brain Tumor Pathol. 2001;18(2):131-7. PubMed PMID: 11908869.

116: Ueki K, Nishikawa R, Nakazato Y, Hirose T, Hirato J, Funada N, Fujimaki T, Hojo S, Kubo O, Ide T, Usui M, Ochiai C, Ito S, Takahashi H, Mukasa A, Asai A, Kirino T. Correlation of histology and molecular genetic analysis of 1p, 19q, 10q, TP53, EGFR, CDK4, and CDKN2A in 91 astrocytic and oligodendroglial tumors. Clin Cancer Res. 2002 Jan;8(1):196-201. PubMed PMID: 11801559.

117: Debinski W, Slagle-Webb B, Achen MG, Stacker SA, Tulchinsky E, Gillespie GY, Gibo DM. VEGF-D is an X-linked/AP-1 regulated putative onco-angiogen in human glioblastoma multiforme. Mol Med. 2001 Sep;7(9):598-608. PubMed PMID: 11778649; PubMed Central PMCID: PMC1950071.

118: Holmin S, von Gertten C, Sandberg-Nordqvist AC, Lendahl U, Mathiesen T. Induction of astrocytic nestin expression by depolarization in rats. Neurosci Lett. 2001 Nov 16;314(3):151-5. PubMed PMID: 11704306.

119: Nozaki M, Tada M, Kobayashi H, Zhang CL, Sawamura Y, Abe H, Ishii N, Van Meir EG. Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression. Neuro Oncol. 1999 Apr;1(2):124-37. doi: 10.1093/neuonc/1.2.124. Review. PubMed PMID: 11550308; PubMed Central PMCID: PMC1920749.

120: Hirano H, Lopes MB, Laws ER Jr, Asakura T, Goto M, Carpenter JE, Karns LR, VandenBerg SR. Insulin-like growth factor-1 content and pattern of expression correlates with histopathologic grade in diffusely infiltrating astrocytomas. Neuro Oncol. 1999 Apr;1(2):109-19. doi: 10.1093/neuonc/1.2.109. PubMed PMID: 11550306; PubMed Central PMCID: PMC1920755.

121: Ichinose M, Masuoka J, Shiraishi T, Mineta T, Tabuchi K. Fas ligand expression and depletion of T-cell infiltration in astrocytic tumors. Brain Tumor Pathol. 2001;18(1):37-42. PubMed PMID: 11517972.

122: Yao Y, Kubota T, Sato K, Kitai R, Takeuchi H, Arishima H. Prognostic value of vascular endothelial growth factor and its receptors Flt-1 and Flk-1 in astrocytic tumours. Acta Neurochir (Wien). 2001;143(2):159-66. PubMed PMID: 11459088.

123: Hayashi Y, Iwato M, Hasegawa M, Tachibana O, von Deimling A, Yamashita J. Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. J Neurosurg. 2001 Jul;95(1):138-42. PubMed PMID: 11453385.

124: Kunkel P, Müller S, Schirmacher P, Stavrou D, Fillbrandt R, Westphal M, Lamszus K. Expression and localization of scatter factor/hepatocyte growth factor in human astrocytomas. Neuro Oncol. 2001 Apr;3(2):82-8. doi: 10.1093/neuonc/3.2.82. PubMed PMID: 11296484; PubMed Central PMCID: PMC1920608.

125: Horvat A, Schwaiger F, Hager G, Brocker F, Streif R, Knyazev P, Ullrich A, Kreutzberg GW. A novel role for protein tyrosine phosphatase shp1 in controlling glial activation in the normal and injured nervous system. J Neurosci. 2001 Feb 1;21(3):865-74. PubMed PMID: 11157073.

126: Evliyaoglu C, Carroll R, Folkerth R, Bello L, Bruns DE, Black PM. Parathyroid hormone-related protein and its receptor in human glial tumors. Acta Neurochir (Wien). 2000;142(8):871-8. PubMed PMID: 11086825.

127: Maruno M, Ninomiya H, Ghulam Muhammad AK, Hirata M, Kato A, Yoshimine T. Whole-genome analysis of human astrocytic tumors by comparative genomic hybridization. Brain Tumor Pathol. 2000;17(1):21-7. PubMed PMID: 10982006.

128: Bechmann I, Lossau S, Steiner B, Mor G, Gimsa U, Nitsch R. Reactive astrocytes upregulate Fas (CD95) and Fas ligand (CD95L) expression but do not undergo programmed cell death during the course of anterograde degeneration. Glia. 2000 Oct;32(1):25-41. PubMed PMID: 10975908.

129: Nishizaki T, Kubota H, Harada K, Harada K, Ito H, Suzuki M, Sasaki K. Clinical evidence of distinct subgroups of astrocytic tumors defined by comparative genomic hybridization. Hum Pathol. 2000 May;31(5):608-14. PubMed PMID: 10836301.

130: Park CK, Ju WK, Hofmann HD, Kirsch M, Ki Kang J, Chun MH, Lee MY. Differential regulation of ciliary neurotrophic factor and its receptor in the rat hippocampus following transient global ischemia. Brain Res. 2000 Apr 10;861(2):345-53. PubMed PMID: 10760496.

131: Rempel SA, Dudas S, Ge S, Gutiérrez JA. Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res. 2000 Jan;6(1):102-11. PubMed PMID: 10656438.

132: Nouel D, Sarret P, Vincent JP, Mazella J, Beaudet A. Pharmacological, molecular and functional characterization of glial neurotensin receptors. Neuroscience. 1999;94(4):1189-97. PubMed PMID: 10625058.

133: Krum JM, Rosenstein JM. Transient coexpression of nestin, GFAP, and vascular endothelial growth factor in mature reactive astroglia following neural grafting or brain wounds. Exp Neurol. 1999 Dec;160(2):348-60. PubMed PMID: 10619552.

134: Feldkamp MM, Lala P, Lau N, Roncari L, Guha A. Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens. Neurosurgery. 1999 Dec;45(6):1442-53. PubMed PMID: 10598712.

135: Frankel B, Longo SL, Ryken TC. Co-expression of Fas and Fas ligand in human non-astrocytic glial tumors. Acta Neuropathol. 1999 Oct;98(4):363-6. PubMed PMID: 10502041.

136: Simard M, Couldwell WT, Zhang W, Song H, Liu S, Cotrina ML, Goldman S, Nedergaard M. Glucocorticoids-potent modulators of astrocytic calcium signaling. Glia. 1999 Oct;28(1):1-12. PubMed PMID: 10498817.

137: Goldbrunner RH, Bernstein JJ, Tonn JC. Cell-extracellular matrix interaction in glioma invasion. Acta Neurochir (Wien). 1999;141(3):295-305; discussion 304-5. Review. PubMed PMID: 10214487.

138: Moriyama T, Kataoka H, Koono M, Wakisaka S. Expression of hepatocyte growth factor/scatter factor and its receptor c-Met in brain tumors: evidence for a role in progression of astrocytic tumors (Review). Int J Mol Med. 1999 May;3(5):531-6. Review. PubMed PMID: 10202187.

139: Nakatani K, Yoshimi N, Mori H, Sakai H, Shinoda J, Andoh T, Sakai N. The significance of the expression of tumor suppressor gene DCC in human gliomas. J Neurooncol. 1998 Dec;40(3):237-42. PubMed PMID: 10066096.

140: Hirose Y, Kojima M, Sagoh M, Hayashi T, Murakami H, Shimazaki K, Yoshida K, Kawase T. Clinical importance of c-Met protein expression in high grade astrocytic tumors. Neurol Med Chir (Tokyo). 1998 Dec;38(12):851-8; discussion 858-9. PubMed PMID: 10063359.

141: Goldbrunner RH, Bernstein JJ, Tonn JC. ECM-mediated glioma cell invasion. Microsc Res Tech. 1998 Nov 1;43(3):250-7. Review. PubMed PMID: 9840803.

142: Hwang SL, Hong YR, Chai CY, Lin HJ, Howng SL. Prognostic evaluation in supratentorial astrocytic tumors using p53, epidermal growth factor receptor, c-erbB-2 immunostaining. Kaohsiung J Med Sci. 1998 Oct;14(10):607-15. PubMed PMID: 9819502.

143: Wang Y, Hagel C, Hamel W, Müller S, Kluwe L, Westphal M. Trk A, B, and C are commonly expressed in human astrocytes and astrocytic gliomas but not by human oligodendrocytes and oligodendroglioma. Acta Neuropathol. 1998 Oct;96(4):357-64. PubMed PMID: 9797000.

144: Cotrina ML, Lin JH, Nedergaard M. Cytoskeletal assembly and ATP release regulate astrocytic calcium signaling. J Neurosci. 1998 Nov 1;18(21):8794-804. PubMed PMID: 9786986.

145: Pilitsis JG, Kimelberg HK. Adenosine receptor mediated stimulation of intracellular calcium in acutely isolated astrocytes. Brain Res. 1998 Jul 6;798(1-2):294-303. PubMed PMID: 9666151.

146: Hirose Y, Kojima M, Sagoh M, Murakami H, Yoshida K, Shimazaki K, Kawase T. Immunohistochemical examination of c-Met protein expression in astrocytic tumors. Acta Neuropathol. 1998 Apr;95(4):345-51. PubMed PMID: 9560011.

147: Khalid H, Shibata S, Kishikawa M, Yasunaga A, Iseki M, Hiura T. Immunohistochemical analysis of progesterone receptor and Ki-67 labeling index in astrocytic tumors. Cancer. 1997 Dec 1;80(11):2133-40. PubMed PMID: 9392336.

148: Hwang SL, Chai CY, Lin HJ, Howng SL. Expression of epidermal growth factor receptors and c-erbB-2 proteins in human astrocytic tumors. Kaohsiung J Med Sci. 1997 Jul;13(7):417-24. PubMed PMID: 9260461.

149: Stewart VC, Giovannoni G, Land JM, McDonald WI, Clark JB, Heales SJ. Pretreatment of astrocytes with interferon-alpha/beta impairs interferon-gamma induction of nitric oxide synthase. J Neurochem. 1997 Jun;68(6):2547-51. PubMed PMID: 9166751.

150: Kamada H, Murakami H, Satone A, Ikeda M, Yamaguchi H, Matsumoto A, Ide W, Hashimoto I, Ukita H. [Up-regulation of NGF, trkA, Fas, down-regulation of bcl-2, and induction of apoptosis by propentofylline in human glioma cell lines]. No To Shinkei. 1996 Nov;48(11):1022-8. Japanese. PubMed PMID: 8951894.

151: Eagle KS, Chalmers GR, Clary DO, Gage FH. Axonal regeneration and limited functional recovery following hippocampal deafferentation. J Comp Neurol. 1995 Dec 18;363(3):377-88. PubMed PMID: 8847406.

152: Carroll RS, Zhang J, Dashner K, Sar M, Black PM. Steroid hormone receptors in astrocytic neoplasms. Neurosurgery. 1995 Sep;37(3):496-503; discussion 503-4. PubMed PMID: 7501116.

153: Lang FF, Miller DC, Koslow M, Newcomb EW. Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors. J Neurosurg. 1994 Sep;81(3):427-36. PubMed PMID: 8057151.

154: Gehrmann J, Yao DL, Bonetti B, Bondy CA, Brenner M, Zhou J, Kreutzberg GW, Webster HD. Expression of insulin-like growth factor-I and related peptides during motoneuron regeneration. Exp Neurol. 1994 Aug;128(2):202-10. PubMed PMID: 8076663.

155: Tada M, Diserens AC, Desbaillets I, de Tribolet N. Analysis of cytokine receptor messenger RNA expression in human glioblastoma cells and normal astrocytes by reverse-transcription polymerase chain reaction. J Neurosurg. 1994 Jun;80(6):1063-73. PubMed PMID: 7514661.

156: Lübke J, Wood MJ, Clarke DJ. Morphological assessment of grafted rat and mouse cortical neurons: a light and electron microscopic study. J Comp Neurol. 1994 Mar 1;341(1):78-94. PubMed PMID: 8006225.

157: Stichel CC, Müller HW. Extensive and long-lasting changes of glial cells following transection of the postcommissural fornix in the adult rat. Glia. 1994 Feb;10(2):89-100. PubMed PMID: 8168870.

158: Yamaguchi F, Saya H, Bruner JM, Morrison RS. Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas. Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):484-8. PubMed PMID: 8290551; PubMed Central PMCID: PMC42973.

159: Morrison RS, Yamaguchi F, Saya H, Bruner JM, Yahanda AM, Donehower LA, Berger M. Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas. J Neurooncol. 1994;18(3):207-16. Review. PubMed PMID: 7964981.

160: Dave V, Vitarella D, Aschner JL, Fletcher P, Kimelberg HK, Aschner M. Lead increases inositol 1,4,5-trisphosphate levels but does not interfere with calcium transients in primary rat astrocytes. Brain Res. 1993 Jul 30;618(1):9-18. PubMed PMID: 8402182.

161: Kristt DA, Reedy E, Yarden Y. Receptor tyrosine kinase expression in astrocytic lesions: similar features in gliosis and glioma. Neurosurgery. 1993 Jul;33(1):106-15. PubMed PMID: 7689190.

162: Rinaman L, Milligan CE, Levitt P. Persistence of fluoro-gold following degeneration of labeled motoneurons is due to phagocytosis by microglia and macrophages. Neuroscience. 1991;44(3):765-76. PubMed PMID: 1721690.

163: Nitta T, Yagita H, Okumura K, Sato K. [Analysis of receptor expression on astrocytic cells]. No To Shinkei. 1990 Oct;42(10):945-50. Japanese. PubMed PMID: 1705127.

164: Yoshimine T, Hayakawa T, Mogami H. [Factors affecting the prognosis of brain tumors]. Gan To Kagaku Ryoho. 1988 Jul;15(7):2022-7. Japanese. PubMed PMID: 2840033.

Aoki Y, Hanai S, Sukigara S, Otsuki T, Saito T, Nakagawa E, Kaido T, Kaneko Y, Takahashi A, Ikegaya N, Iwasaki M, Sugai K, Sasaki M, Goto Y, Oka A, Itoh M. Altered Expression of Astrocyte-Related Receptors and Channels Correlates With Epileptogenesis in Hippocampal Sclerosis. Pediatr Dev Pathol. 2019 Jun 5:1093526619855488. doi: 10.1177/1093526619855488. [Epub ahead of print] PubMed PMID: 31166880.
  • astrocytic_receptor.txt
  • Last modified: 2020/09/14 15:47
  • by administrador