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basal_ganglia

Basal ganglia

The basal ganglia (or basal nuclei) comprises multiple subcortical nuclei, of varied origin, in the brain, which are situated at the base of the forebrain.

Components

Interconnections

Basal ganglia are strongly interconnected with the cerebral cortex, thalamus, and brainstem, as well as several other brain areas. The basal ganglia is associated with a variety of functions including: control of voluntary motor movements, procedural learning, routine behaviors or “habits” such as bruxism, eye movements, cognition and emotion.


Over the past years, research into the neurophysiology of the basal ganglia has provided new insights into the pathophysiology of movement disorders. The presence of pathological oscillations at specific frequencies has been linked to different signs and symptoms in PD and dystonia, suggesting a new model to explain basal ganglia dysfunction. These advances occurred in parallel with improvements in imaging and neurosurgical techniques, both of which having facilitated the more widespread use of DBS to modulate dysfunctional circuits. High-frequency stimulation is thought to disrupt pathological activity in the motor cortex/basal ganglia network; however, it is not easy to explain all of its effects based only on changes in network oscillations 1).

Pathology

1)
Guridi J, Alegre M. Oscillatory activity in the basal ganglia and deep brain stimulation. Mov Disord. 2016 Aug 22. doi: 10.1002/mds.26714. [Epub ahead of print] Review. PubMed PMID: 27548437.
basal_ganglia.txt · Last modified: 2018/03/20 23:29 by administrador