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beta_catenin

Beta Catenin

Catenin (cadherin-associated protein), beta 1, 88kDa (the HUGO-approved official symbol, CTNNB1; HGNC ID, HGNC:2514), also called beta-catenin (or β-catenin), is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene.

Beta catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway.

Beta catenin is a well-known crucial factor in astrocytoma progression and it is involved in aquaporin 1 (AQP1) mediated cell migration.

In a study, Zhang et al. revealed the function of AQP1 in astrocytoma progression and provided the first clinical evidence that AQP1 expression was positively correlated with β-catenin. Furthermore, they proved the functional role of AQP1/β-catenin pathway in astrocytoma progression. More importantly, they discovered that combination of AQP1 and β-catenin expression was an independent prognosis factor for astrocytoma patients and it was a better survival predictor than either AQP1 or β-catenin alone. In conclusion, the study provided a novel more precise prognostication for predicting astrocytoma prognosis based on combinatorial analysis of AQP1 and β-catenin expression 1).

It is a member of the catenin protein family and homologous to γ-catenin.

Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer.

β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).


Wnt/β-catenin signaling pathway is frequently dysregulated in human tumors and plays a critical role in tumorigenesis; however, the roles of microRNAs in mediating Wnt/β-catenin pathway are not well understood.


Expression of WNT3a, cytoplasmic β-catenin and TCF4 was significantly associated with the histological malignancy grade and with a worse prognosis for patients with glioma 2).

1)
Zhang H, Qin F, Yang L, He J, Liu X, Shao Y, Guo Z, Zhang M, Li W, Fu L, Gu F, Ma Y. Combination of AQP1 and β-catenin expression is an independent prognosis factor in astrocytoma patients. Oncotarget. 2017 Jul 26. doi: 10.18632/oncotarget.19562. [Epub ahead of print] PubMed PMID: 28767413.
2)
Denysenko T, Annovazzi L, Cassoni P, Melcarne A, Mellai M, Schiffer D. WNT/β-catenin Signaling Pathway and Downstream Modulators in Low- and High-grade Glioma. Cancer Genomics Proteomics. 2016 01-02;13(1):31-45. PubMed PMID: 26708597.
beta_catenin.txt · Last modified: 2018/03/31 16:51 by administrador