Tumor Paint BLZ100, a tumor ligand chlorotoxin (CTX) conjugated to indocyanine Green (ICG), has shown potential to be a targeted contrast agent. There are many infrared imaging systems (NIR) in use, but they are not optimized to the low concentration and amount of ICG
BLZ-100 has a very high affinity toward human gliomas. They also describe a small, cost-effective, and sensitive NIR system for visualizing brain tumors tagged using BLZ-100. Butte et al. hope that the use of BLZ-100 along with near infrared optical imaging imaging will be useful to delineate the brain tumors in real time and assist surgeons in near-complete tumor removal to increase survival and reduce neurological deficits 1).