The most frequent site of bone metastasis are vertebral metastases, likely related to the high hematopoietic activity and vascularization of the spine
The spine is the commonest site for bone metastases, and the incidence of spinal metastases is increasing
Approximately two-thirds of cancer patients will develop bone metastases and it is estimated that over 10% of patients with cancer will develop symptomatic spinal metastases.
More than 50% of patients with spinal metastases have multiple levels involved.
see Skull metastases
see Spinal metastases
Cancer cells that break off from a primary tumor and enter the bloodstream or lymph vessels can reach nearly all tissues of the body. Bones are a common place for these cancer cells to settle and start growing. Tumors that result from these cells entering the bones are called bone metastases.