Brain tumor

A brain tumor or brain tumour, is an intracranial solid neoplasm, a tumor within the brain.

Brain tumors include all tumors inside the human skull (cranium) or in the central spinal canal. They are created by an abnormal and uncontrolled cell division, usually in the brain itself, but also in lymphatic tissue, in blood vessels, in the cranial nerves, in the brain envelopes (meninges), skull, pituitary gland, or pineal gland.

The complex pathophysiology of brain tumors is dependent on various factors, including histology, molecular and chromosomal aberration, tumor-related protein expression, primary versus secondary origin, and host factors 1) 2) 3) 4).

Although brain tumors occur less frequently than other forms of cancer, they have one of the bleakest prognoses with low survival rates.

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Kleihues P, Sobin LH. World Health Organization classification of tumors. Cancer 2000;88:2887.
Kleihues P, Ohgaki H. Phenotype vs genotype in the evolution of astrocytic brain tumors. Toxicol Pathol 2000;28:164 –170.
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