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Calcitonin gene-related peptide

Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides, which in humans exists in two forms: α-CGRP and β-CGRP, also known as CGRP I and CGRP II.

α-CGRP is a 37-amino acid neuropeptide and is formed from the alternative splicing of the calcitonin/CGRP gene located on chromosome 11. β-CGRP is less studied. In humans, β-CGRP differs from the α-CGRP by three amino acids and is encoded in a separate gene within the same vicinity.

The CGRP family includes calcitonin (CT), adrenomedullin (AM), and amylin (AMY).

Alexoudi A, Deftereos S. CGRP Antagonists: Side Effects and Potential Parkinson's Disease Development. Headache. 2020 Apr;60(4):789-790. doi: 10.1111/head.13770. PubMed PMID: 32219862.

Gherardini G, Lundeberg T, Cui JG, Eriksson SV, Trubek S, Linderoth B. Spinal cord stimulation improves survival in ischemic skin flaps: an experimental study of the possible mediation by calcitonin gene-related peptide. Plast Reconstr Surg. 1999 Apr;103(4):1221-8. PubMed PMID: 10088510.

calcitonin_gene-related_peptide.txt · Last modified: 2020/03/29 15:41 by administrador