Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase 3. CASP8 orthologs have been identified in numerous mammals for which complete genome data are available. These unique orthologs are also present in birds.
It was found to be only associated with breast cancer risk. Therefore, these two CASP8 variations could be regarded as potential biomarkers for cancer risk 1).