Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene.

It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins.

The protein encoded by this gene is a member of the cyclin-dependent kinase, (CDK) family, which includes CDK4.

CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression in the point of regulation named R or restriction point.