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Cerebellar cavernous malformation

Cerebellar giant intracranial cavernous malformation are extremely rare, with only seven cases reported based on English literature. These lesions are most commonly seen in the pediatric age group, which is known to have an increased risk of hemorrhage.

They are in children symptomatic lesions.

Radiologically and clinically they can mimic a tumor with bleed, having to be considered in the differential diagnosis of neoplastic lesions. Cerebellar GCMs might be suspected in the presence of large hemorrhagic intra-axial mass with “bubbles of blood,” multi-cystic appearance, surrounded by hemosiderin rim, fluid-fluid levels, and accompanying edema-mass effect. Careful radiological study provides a preoperative diagnosis, but its confirmation requires histopathological examination. Complete surgical removal should be attempted when possible 1).

Case reports

An 18-month-old girl presented with a 6-month history of cervical torticollis and upper extremities clumsiness. An MRI revealed a 57 × 46 × 42 mm multi-cystic, left cerebellar hemisphere mass, showing areas of hemorrhages and cysts with various stages of thrombus. There was no enhancement with contrast. Cerebral angiography ruled out an arteriovenous malformation. She underwent a left paramedian occipital craniotomy, and macroscopic gross total resection was accomplished.

Histopathologic examination was consistent with a cavernous malformation. After surgery, the patient had no new neurological deficit and an uneventful postoperative recovery. Follow-up MRI confirmed total removal of the lesion 2).

1) , 2)
Villaseñor-Ledezma J, Budke M, Alvarez-Salgado JA, Cañizares MA, Moreno L, Villarejo F. Pediatric cerebellar giant cavernous malformation: case report and review of literature. Childs Nerv Syst. 2017 Jul 25. doi: 10.1007/s00381-017-3550-7. [Epub ahead of print] PubMed PMID: 28744689.
cerebellar_cavernous_malformation.txt · Last modified: 2017/07/27 21:49 by administrador