Cerebral arteriovenous malformation outcome

Size of the brain arteriovenous malformation is highly significant to seizure occurrence. Patients with cerebral hemorrhage are prone to having an acute seizure occurrence. Radiosurgery, embolization, and microsurgery could all influence seizure control and reduce the risk of rebleeding in pediatric bAVMs patients 1).

Radiosurgery provides reasonable rates of seizure improvement for patients with AVM who present with seizures 2). For patients with AVM without seizures at presentation, the risk of de novo seizures after radiosurgery is very low, obviating the need for prophylactic antiepileptic drug therapy. Further investigation of epilepsy in patients with AVM undergoing stereotactic radiosurgery should be considered with validated outcome measures and prospective study design 3).

Microsurgery led to the highest percentage of seizure-free outcomes and had the lowest annual bleeding rate, whereas radiosurgery had a higher bleeding rate. Median time to seizure-free status in surgically treated patients was shorter than in patients who underwent radiosurgical or endovascular treatment 4)

Liu S, Chen HX, Mao Q, You C, Xu JG. Factors associated with seizure occurrence and long-term seizure control in pediatric brain arteriovenous malformation: a retrospective analysis of 89 patients. BMC Neurol. 2015 Aug 27;15:155. doi: 10.1186/s12883-015-0402-5. PMID: 26311038; PMCID: PMC4550043.
Chen CJ, Chivukula S, Ding D, Starke RM, Lee CC, Yen CP, Xu Z, Sheehan JP. Seizure outcomes following radiosurgery for cerebral arteriovenous malformations. Neurosurg Focus. 2014 Sep;37(3):E17. doi: 10.3171/2014.6.FOCUS1454. PMID: 25175436.
Ding D, Quigg M, Starke RM, Yen CP, Przybylowski CJ, Dodson BK, Sheehan JP. Cerebral Arteriovenous Malformations and Epilepsy, Part 2: Predictors of Seizure Outcomes Following Radiosurgery. World Neurosurg. 2015 Sep;84(3):653-62. doi: 10.1016/j.wneu.2015.04.064. Epub 2015 May 28. PMID: 26026628.
Hyun SJ, Kong DS, Lee JI, Kim JS, Hong SC. Cerebral arteriovenous malformations and seizures: differential impact on the time to seizure-free state according to the treatment modalities. Acta Neurochir (Wien). 2012 Jun;154(6):1003-10. doi: 10.1007/s00701-012-1339-8. Epub 2012 Apr 11. PMID: 22492295.
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  • Last modified: 2021/05/04 20:08
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