Cerebral arteriovenous malformation surgery

see Cerebral arteriovenous malformation surgery videos

At the early stage of cerebral arteriovenous malformation surgery, extensive dissection of the sulci, fissures, and subarachnoid cistern should be performed to expose feeders, nidus, and drainers. Problems with the surgery of large and/or deep-seated lesions are exacerbated when arterial bleeding from the nidus continues even after all major feeders are thought to have been occluded.

Temporary clip application on feeders and less coagulation of the nidus is necessary to control intranidal pressure and to avoid uncontrollable bleeding from the nidus and adjacent brain. Intraoperative navigation images superimposed on tractography images can provide us with valuable information to minimize neurological deficits. Deeper insight into AVM nature and into events that occur during AVM surgery will open new horizons for the safe and effective treatment of AVMs 1).

The most important factors governing the operability of an AVM are location, size, age of the patient, and the neurosurgeon's and team's experience.

Hernesniemi et al. present in a review the surgical experience. This consists of the following steps: (1) accurate preoperative embolization; (2) optimal selection of the surgical approach; (3) accurate definition and preservation of the normal arterial vessels of passage; (4) temporary clipping of the feeding arteries; (5) a special method of coagulation called “dirty coagulation” of the deep small difficult vessels inside apparently normal brain around the AVM; (6) removal of all AVM; (7) meticulous hemostasis; (8) intra- and postoperative digital subtraction angiography (DSA); (9) clinical and radiological follow-up. These steps are not possible in AVMs lying entirely within central eloquent areas. Nine out of ten small- and medium-sized arteriovenous malformations (AVMs) are suitable for direct surgery, but surgical complications increase drastically with the size of the AVM. Nevertheless, the actual results of combined treatment with preoperative Onyx embolization followed by microsurgery have decreased these risks 2).

Wang et al. evaluated the application of intraoperative ultrasound (IOU) combined with indocyanine green videoangiography for arteriovenous malformation and concluded that it can identify the boundary of AVM, detect deep vessels, and discriminate between feeding arteries and draining veins, reducing operation difficulty, decreasing mortality and disability rate, and increasing the rate of complete excision 3).


Data of patients with AVM were collected prospectively. Cases were identified in which an AVM was resected and an associated space-occupying ICH was evacuated at the same time, and divided into “group 1,” in which the surgery was performed acutely within 48 h of presentation (secondary to elevated intracranial pressure); and “group 2,” in which selected patients were operated upon in the presence of a liquefying ICH in the “subacute” stage. Clinical outcomes were assessed using the modified Rankin Scale, with a score of 0 to 2 considered a good outcome. Obliteration rates were assessed using postoperative angiography.

From 2001 to 2015, 131 patients underwent microsurgical resection of an AVM, of which 65 cases were included. In “group 1” (n = 21; Spetzler-Ponce class A = 13, class B = 5, and class C = 3), 11 of 21 (52%) had a good outcome and in 18 of 19 (95%) of those who had a postoperative angiogram the AVMs were completely obliterated. In “group 2” (n = 44; Spetzler-Ponce class A = 33, class B = 9, and class C = 2), 31 of 44 (93%) had a good outcome and 42 of 44 (95%) were obliterated with a single procedure. For supratentorial AVMs, the ICH cavity was utilized to provide an operative trajectory to a deep AVM in 11 cases, and in 26 cases the ICH cavity was deep to the AVM and hence facilitated the deep dissection of the nidus.

In selected patients the presence of a liquefying ICH cavity may facilitate the resection of AVMs when performed in the subacute stage resulting in a good neurological outcome and high obliteration rate 4).


A total of 264 patients were treated with microsurgical resection between 1994 and 2010 at the Jefferson Hospital for Neuroscience. Initial hemorrhage, clinical presentation, Spetzler-Martin AVM grading system (SM), treatment modalities, clinical outcomes, and obliteration rates were reviewed.

Univariate analysis and multivariate analysis were used to determine predictors of operative complications.

Of the 264 patients treated with microsurgery, 120 (45%) patients initially presented with hemorrhage. There were 27 SM Grade I lesions (10.2%), 101 Grade II lesions (38.3%), 96 Grade III lesions (36.4%), 31 Grade IV lesions (11.7%), and 9 Grade V lesions (3.4%). Among these patients, 102 (38.6%) had undergone prior endovascular embolization. In all patients, resection resulted in complete obliteration of the AVM. Complications occurred in 19 (7.2%) patients and resulted in permanent neurological deficits in 5 (1.9%). In multivariate analysis, predictors of complications were increasing AVM size (OR 3.2, 95% CI 1.5-6.6; p = 0.001), increasing number of embolizations (OR 1.6, 95% CI 1.1-2.2; p = 0.01), and unruptured cerebral arteriovenous malformation (OR 2.7, 95% CI 1-7.2; p = 0.05).

Microsurgical resection of AVMs is highly efficient and can be undertaken with low rates of morbidity at high-volume neurovascular centers. Unruptured and larger AVMs were associated with higher complication rates 5).

Occult AVM nidus in symptomatic left temporal arteriovenous malformations: operative management strategies in two sister cases 6).

Hashimoto N, Nozaki K, Takagi Y, Kikuta K, Mikuni N. Surgery of cerebral arteriovenous malformations. Neurosurgery. 2007 Jul;61(1 Suppl):375-87; discussion 387-9. doi: 10.1227/01.NEU.0000255491.95944.EB. Review. PubMed PMID: 18813152.
Hernesniemi J, Romani R, Lehecka M, Isarakul P, Dashti R, Celik O, Navratil O, Niemelä M, Laakso A. Present state of microneurosurgery of cerebral arteriovenous malformations. Acta Neurochir Suppl. 2010;107:71-6. doi: 10.1007/978-3-211-99373-6_11. Review. PubMed PMID: 19953374.
Wang H, Ye ZP, Huang ZC, Luo L, Chen C, Guo Y. Intraoperative Ultrasonography Combined with Indocyanine Green Video-Angiography in Patients with Cerebral Arteriovenous Malformations. J Neuroimaging. 2015 Mar 19. doi: 10.1111/jon.12232. [Epub ahead of print] PubMed PMID: 25800700.
Barone DG, Marcus HJ, Guilfoyle MR, Higgins JN, Antoun N, Santarius T, Trivedi RA, Kirollos RW. Clinical Experience and Results of Microsurgical Resection of Arterioveonous Malformation in the Presence of Space-Occupying Intracerebral Hematoma. Neurosurgery. 2017 Mar 15. doi: 10.1093/neuros/nyx003. [Epub ahead of print] PubMed PMID: 28328006.
Theofanis T, Chalouhi N, Dalyai R, Starke RM, Jabbour P, Rosenwasser RH, Tjoumakaris S. Microsurgery for cerebral arteriovenous malformations: postoperative outcomes and predictors of complications in 264 cases. Neurosurg Focus. 2014 Sep;37(3):E10. doi: 10.3171/2014.7.FOCUS14160. PubMed PMID: 25175429.
Glauser G, Pisapia JM, Piazza M, Choudhri O. Occult AVM nidus in symptomatic left temporal arteriovenous malformations: operative management strategies in two sister cases. BMJ Case Rep. 2019 Jul 27;12(7). pii: e231452. doi: 10.1136/bcr-2019-231452. PubMed PMID: 31352403.
  • cerebral_arteriovenous_malformation_surgery.txt
  • Last modified: 2019/07/30 10:09
  • by administrador