Cerebral large artery disease (CLAD) is defined as stenosis or occlusion of either the carotid artery or the middle cerebral artery of 50% or more.
In patients with CLAD, elevated plasma VEGF might be associated with cerebral microbleeds (CMBs), especially those located in the cortex and/or at the gray-white junction.
Large artery atherosclerosis is an important cause of ischemic stroke. Recent randomized clinical trials have helped clarify the treatment options for conditions such as Carotid artery atherosclerotic disease and intracranial atherosclerosis.
see Carotid artery atherosclerotic disease.