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Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina.

It is in a tertiary care academic medical center, that have implemented a voluntary wellness initiative involving both faculty and residents. This program encourages and educates participants in the importance of regular exercise, balanced nutrition, stress management, and adequate sleep, among others, in a team-based approach with scheduled exercise sessions and team-building activities

(see the Wellness Protocol, Supplemental Digital Content 1, http:

The aim is to increase awareness of the importance of a balanced lifestyle and provide support and resources to establish lifelong habits of personal health.

A report details the baseline data that were collected as part of this quality improvement initiative to better define the starting point for this population.


Wagner JL, Kellermann TS, Mueller M, Smith G. Response to “Screening for depression in youth with epilepsy: The NDDI-E-Y”. Epilepsia. 2018 Oct;59(10):2000-2001. doi: 10.1111/epi.14558. PubMed PMID: 30368790.

2: Vargas J, Spiotta A, Chatterjee AR. Initial Experiences with Artificial Neural Networks in Detection of CT Perfusion Deficits. World Neurosurg. 2018 Oct 23. pii: S1878-8750(18)32382-9. doi: 10.1016/j.wneu.2018.10.084. [Epub ahead of print] PubMed PMID: 30366140.

3: Murphy MP, Kuramatsu JB, Leasure A, Falcone GJ, Kamel H, Sansing LH, Kourkoulis C, Schwab K, Elm JJ, Gurol ME, Tran H, Greenberg SM, Viswanathan A, Anderson CD, Schwab S, Rosand J, Shi FD, Kittner SJ, Testai FD, Woo D, Langefeld CD, James ML, Koch S, Huttner HB, Biffi A, Sheth KN. Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage. Stroke. 2018 Nov;49(11):2652-2658. doi: 10.1161/STROKEAHA.118.021799. PubMed PMID: 30355194.

4: Almallouhi E, Al Kasab S, Harvey JB, Reardon C, Alawieh A, Girotra T, Aysse P, Turner RD 4th, Holmstedt CA. Impact of Treatment Time on the Long-Term Outcome of Stroke Patients Treated With Mechanical Thrombectomy. J Stroke Cerebrovasc Dis. 2018 Oct 19. pii: S1052-3057(18)30549-4. doi: 10.1016/j.jstrokecerebrovasdis.2018.09.033. [Epub ahead of print] PubMed PMID: 30343988.

5: Jester R, Znoyko I, Garnovskaya M, Rozier JN, Kegl R, Patel S, Tran T, Abedalthagafi M, Horbinski CM, Richardson M, Wolff DJ, Lapadat R, Moore W, Rodriguez FJ, Mull J, Olar A. Expression of renal cell markers and detection of 3p loss links endolymphatic sac tumor to renal cell carcinoma and warrants careful evaluation to avoid diagnostic pitfalls. Acta Neuropathol Commun. 2018 Oct 19;6(1):107. doi: 10.1186/s40478-018-0607-0. PubMed PMID: 30340515.

6: Wolfe SQ, West JL, Hunt MA, Murad GJA, Fox WC, Dow J, Morone PJ, Wellons JC 3rd, Podet A, Wilson J, Wu JK, Spiotta AM, Fargen KM. A Comparison of the Existing Wellness Programs in Neurosurgery and Institution Champion's Perspectives. Neurosurgery. 2018 Oct 16. doi: 10.1093/neuros/nyy418. [Epub ahead of print] PubMed PMID: 30329099.

7: Lee JS, Lee SJ, Yoo JS, Hong JH, Kim CH, Kim YW, Kang DH, Kim YS, Hong JM, Choi JW, Ovbiagele B, Demchuk AM, Sohn SI, Hwang YH. Prognosis of Acute Intracranial Atherosclerosis-Related Occlusion after Endovascular Treatment. J Stroke. 2018 Sep;20(3):394-403. doi: 10.5853/jos.2018.01627. Epub 2018 Sep 30. PubMed PMID: 30309234; PubMed Central PMCID: PMC6186924.

8: Fiorella D, Boulos A, Turk AS, Siddiqui AH, Arthur AS, Diaz O, Lopes DK; LVIS investigators. The safety and effectiveness of the LVIS stent system for the treatment of wide-necked cerebral aneurysms: final results of the pivotal US LVIS trial. J Neurointerv Surg. 2018 Oct 8. pii: neurintsurg-2018-014309. doi: 10.1136/neurintsurg-2018-014309. [Epub ahead of print] PubMed PMID: 30297543.

9: Spiotta AM, Fiorella D, Arthur AS, Frei D, Turk AS, Hirsch JA. The semiotics of distal thrombectomy: towards a TICI score for the target vessel. J Neurointerv Surg. 2018 Oct 8. pii: neurintsurg-2018-014353. doi: 10.1136/neurintsurg-2018-014353. [Epub ahead of print] PubMed PMID: 30297542.

10: Chandran R, Capone M, Matzelle D, Polcyn R, Kau E, Haque A, Banik NL. Distinct Cytokine and Chemokine Expression in Plasma and Calpeptin-Treated PBMCs of a Relapsing-Remitting Multiple Sclerosis Patient: A Case Report. Neurochem Res. 2018 Oct 5. doi: 10.1007/s11064-018-2655-z. [Epub ahead of print] PubMed PMID: 30291537.

11: Brasiliense LBC, Aguilar-Salinas P, Lopes DK, Nogueira D, DeSousa K, Nelson PK, Moran CJ, Mazur MD, Taussky P, Park MS, Dabus G, Linfante I, Chaudry I, Turner RD, Spiotta AM, Turk AS, Siddiqui AH, Levy EI, Hopkins LN, Arthur AS, Nickele C, Gonsales D, Sauvageau E, Hanel RA. Multicenter Study of Pipeline Flex for Intracranial Aneurysms. Neurosurgery. 2018 Sep 17. doi: 10.1093/neuros/nyy422. [Epub ahead of print] PubMed PMID: 30239959.

12: Spiotta AM. Incorporation of Personality Typing into a Neurologic Surgery Residency Program: Utility in Systems Based Practice, Professionalism, and Self-Reflection. World Neurosurg. 2018 Sep 11. pii: S1878-8750(18)32027-8. doi: 10.1016/j.wneu.2018.09.007. [Epub ahead of print] PubMed PMID: 30213671.

13: Das A, Henderson F Jr, Lowe S, Wallace GC 4th, Vandergrift WA 3rd, Lindhorst SM, Varma AK, Infinger LK, Giglio P, Banik NL, Patel SJ, Cachia D. Single agent efficacy of the HDAC inhibitor DATS in preclinical models of glioblastoma. Cancer Chemother Pharmacol. 2018 Sep 12. doi: 10.1007/s00280-018-3684-7. [Epub ahead of print] PubMed PMID: 30209569.

14: Rizk H, Agrawal Y, Barthel S, Bennett ML, Doherty JK, Gerend P, Gold DR, Morrill D, Oas JG, Roberts JK, Woodson E, Zapala DA, Bennett A, Shenoy AM. Quality improvement in neurology: Neuro-otology quality measurement set. Neurology. 2018 Oct 9;91(15):697-701. doi: 10.1212/WNL.0000000000006217. Epub 2018 Aug 31. PubMed PMID: 30171079.

15: Spiotta AM, Fargen KM, Patel S, Larrew T, Turner RD. Impact of a Residency-Integrated Wellness Program on Resident Mental Health, Sleepiness, and Quality of Life. Neurosurgery. 2018 Aug 30. doi: 10.1093/neuros/nyy112. [Epub ahead of print] PubMed PMID: 30169852.

16: Spiotta AM. Pursuing Wellness in Neurosurgery: Resiliency. Neurosurgery. 2018 Aug 30. doi: 10.1093/neuros/nyy113. [Epub ahead of print] PubMed PMID: 30169794.

17: Rizk H, Agrawal Y, Barthel S, Bennett ML, Doherty JK, Gerend P, Gold DR, Morrill D, Oas JG, Roberts JK, Woodson E, Zapala DA, Bennett A, Shenoy AM. Quality Improvement in Neurology: Neurotology Quality Measurement Set. Otolaryngol Head Neck Surg. 2018 Oct;159(4):603-607. doi: 10.1177/0194599818790947. Epub 2018 Aug 31. PubMed PMID: 30168353.

18: Lowe SR, Alshareef MA, Kellogg RT, Eriksson EA, Kalhorn SP. A Novel Surgical Technique for Management of Giant Central Calcified Thoracic Disk Herniations: A Dual Corridor Method Involving Tubular Transthoracic/Retropleural Approach Followed by a Posterior Transdural Diskectomy. Oper Neurosurg (Hagerstown). 2018 Aug 14. doi: 10.1093/ons/opy225. [Epub ahead of print] PubMed PMID: 30124999.

19: Karsy M, Henderson F Jr, Tenny S, Guan J, Amps JW, Friedman AH, Spiotta AM, Patel S, Kestle JRW, Jensen RL, Couldwell WT. Attitudes and opinions of US neurosurgical residents toward research and scholarship: a national survey. J Neurosurg. 2018 Aug 17:1-12. doi: 10.3171/2018.3.JNS172846. [Epub ahead of print] PubMed PMID: 30117774.

20: Buchholz AL, Henderson F Jr, Lowe S, Alshareef M, Wolgamott L, Patel S, Spiotta AM. Perspectives from a Residency Training Program Following the Implementation of a Wellness Initiative. World Neurosurg. 2018 Nov;119:e947-e955. doi: 10.1016/j.wneu.2018.08.009. Epub 2018 Aug 10. PubMed PMID: 30103061.

21: Spiotta AM, Buchholz AL, Pierce AK, Dahlkoetter J, Armonda R. The Neurosurgeon as a High-Performance Athlete: Parallels and Lessons Learned from Sports Psychology. World Neurosurg. 2018 Aug 10. pii: S1878-8750(18)31794-7. doi: 10.1016/j.wneu.2018.08.013. [Epub ahead of print] PubMed PMID: 30103054.

22: Gleichgerrcht E, Munsell B, Bhatia S, Vandergrift WA 3rd, Rorden C, McDonald C, Edwards J, Kuzniecky R, Bonilha L. Deep learning applied to whole-brain connectome to determine seizure control after epilepsy surgery. Epilepsia. 2018 Sep;59(9):1643-1654. doi: 10.1111/epi.14528. Epub 2018 Aug 10. PubMed PMID: 30098002.

23: Turk AS, Spiotta A, Frei D, Mocco J, Baxter B, Fiorella D, Siddiqui A, Mokin M, Dewan M, Woo H, Turner R, Hawk H, Miranpuri A, Chaudry I. Initial clinical experience with the ADAPT technique: A direct aspiration first pass technique for stroke thrombectomy. J Neurointerv Surg. 2018 Jul;10(Suppl 1):i20-i25. doi: 10.1136/neurintsurg-2013-010713.rep. PubMed PMID: 30037948.

24: Turk AS, Frei D, Fiorella D, Mocco J, Baxter B, Siddiqui A, Spiotta A, Mokin M, Dewan M, Quarfordt S, Battenhouse H, Turner R, Chaudry I. ADAPT FAST study: a direct aspiration first pass technique for acute stroke thrombectomy. J Neurointerv Surg. 2018 Jul;10(Suppl 1):i4-i7. doi: 10.1136/neurintsurg-2014-011125.rep. PubMed PMID: 30037944.

25: McDonald WS, Jones EE, Wojciak JM, Drake RR, Sabbadini RA, Harris NG. Matrix-Assisted Laser Desorption Ionization Mapping of Lysophosphatidic Acid Changes after Traumatic Brain Injury and the Relationship to Cellular Pathology. Am J Pathol. 2018 Aug;188(8):1779-1793. doi: 10.1016/j.ajpath.2018.05.005. Epub 2018 Jul 16. PubMed PMID: 30037420; PubMed Central PMCID: PMC6099387.

26: Goyal N, Tsivgoulis G, Frei D, Turk A, Baxter B, Froehler MT, Mocco J, Ishfaq MF, Malhotra K, Chang JJ, Hoit D, Elijovich L, Loy D, Turner RD, Mascitelli J, Espaillat K, Alexandrov AV, Arthur AS. Comparative Safety and Efficacy of Modified TICI 2b and TICI 3 Reperfusion in Acute Ischemic Strokes Treated With Mechanical Thrombectomy. Neurosurgery. 2018 Sep 1;83(3):593. doi: 10.1093/neuros/nyy320. PubMed PMID: 30010960.

27: Chartrain AG, Shoirah H, Jauch EC, Mocco J. A review of acute ischemic stroke triage protocol evidence: a context for discussion. J Neurointerv Surg. 2018 Nov;10(11):1047-1052. doi: 10.1136/neurintsurg-2018-013951. Epub 2018 Jul 12. Review. PubMed PMID: 30002087.

28: Marks MP, Heit JJ, Lansberg MG, Kemp S, Christensen S, Derdeyn CP, Rasmussen PA, Zaidat OO, Broderick JP, Yeatts SD, Hamilton S, Mlynash M, Albers GW; DEFUSE 3 Investigators. Endovascular Treatment in the DEFUSE 3 Study. Stroke. 2018 Aug;49(8):2000-2003. doi: 10.1161/STROKEAHA.118.022147. PubMed PMID: 29986935; PubMed Central PMCID: PMC6202142.

29: Georgescu MM, Olar A, Mobley BC, Faust PL, Raisanen JM. Epithelial differentiation with microlumen formation in meningioma: diagnostic utility of NHERF1/EBP50 immunohistochemistry. Oncotarget. 2018 Jun 19;9(47):28652-28665. doi: 10.18632/oncotarget.25595. eCollection 2018 Jun 19. PubMed PMID: 29983887; PubMed Central PMCID: PMC6033365.

30: McDonald JS, Steckler EM, McDonald RJ, Katzberg RW, Williamson EE, Cernigliaro JG, Hamadah AM, Gharaibeh K, Kallmes DF, Leung N. Bilateral Sustained Nephrograms After Parenteral Administration of Iodinated Contrast Material: A Potential Biomarker for Acute Kidney Injury, Dialysis, and Mortality. Mayo Clin Proc. 2018 Jul;93(7):867-876. doi: 10.1016/j.mayocp.2018.02.023. PubMed PMID: 29976375.

31: Papanagiotou P, Haussen DC, Turjman F, Labreuche J, Piotin M, Kastrup A, Steglich-Arnholm H, Holtmannspötter M, Taschner C, Eiden S, Nogueira RG, Boutchakova M, Siddiqui A, Lapergue B, Dorn F, Cognard C, Killer M, Mangiafico S, Ribo M, Psychogios MN, Spiotta A, Labeyrie MA, Biondi A, Mazighi M, Richard S, Anxionnat R, Bracard S, Gory B; TITAN Investigators. Carotid Stenting With Antithrombotic Agents and Intracranial Thrombectomy Leads to the Highest Recanalization Rate in Patients With Acute Stroke With Tandem Lesions. JACC Cardiovasc Interv. 2018 Jul 9;11(13):1290-1299. doi: 10.1016/j.jcin.2018.05.036. PubMed PMID: 29976365.

32: Lee SJ, Hwang YH, Hong JM, Choi JW, Yoon BS, Kang DH, Kim YW, Kim YS, Hong JH, Yoo J, Kim CH, Ovbiagele B, Demchuk AM, Sohn SI, Lee JS. Impact of varying levels of hyperglycemia on clinicoradiographic outcomes after endovascular reperfusion treatment. Sci Rep. 2018 Jun 29;8(1):9832. doi: 10.1038/s41598-018-28175-6. PubMed PMID: 29959399; PubMed Central PMCID: PMC6026188.

33: Pacult MA, Henderson FC Jr, Wooster MD, Varma AK. Sciatica Caused by Venous Varix Compression of the Sciatic Nerve. World Neurosurg. 2018 Sep;117:242-245. doi: 10.1016/j.wneu.2018.06.058. Epub 2018 Jun 19. PubMed PMID: 29929032.

34: Neyens RR, Gaskill GE, Chalela JA. Critical Care Management of Anti-N-Methyl-D-Aspartate Receptor Encephalitis. Crit Care Med. 2018 Sep;46(9):1514-1521. doi: 10.1097/CCM.0000000000003268. PubMed PMID: 29927776.

35: Michaelis R, Tang V, Goldstein LH, Reuber M, LaFrance WC Jr, Lundgren T, Modi AC, Wagner JL. Psychological treatments for adults and children with epilepsy: Evidence-based recommendations by the International League Against Epilepsy Psychology Task Force. Epilepsia. 2018 Jul;59(7):1282-1302. doi: 10.1111/epi.14444. Epub 2018 Jun 19. PubMed PMID: 29917225.

36: Schlenz AM, Hayes J, Mueller M, Phillips S, Adams RJ, Kanter J. Incomplete implementation of guideline-based stroke prevention therapy in sickle cell disease. Am J Hematol. 2018 Sep;93(9):E222-E224. doi: 10.1002/ajh.25163. Epub 2018 Aug 6. PubMed PMID: 29905391; PubMed Central PMCID: PMC6168399.

37: Zhao W, Shang S, Li C, Wu L, Wu C, Chen J, Song H, Zhang H, Zhang Y, Duan J, Feng W, Ji X. Long-term outcomes of acute ischemic stroke patients treated with endovascular thrombectomy: A real-world experience. J Neurol Sci. 2018 Jul 15;390:77-83. doi: 10.1016/j.jns.2018.03.004. Epub 2018 Mar 4. PubMed PMID: 29801912.

38: Spiotta AM, Kalhorn S, Patel S. Millenials in Neurosurgery: Is there Hope? Neurosurgery. 2018 Aug 1;83(2):E71-E73. doi: 10.1093/neuros/nyy228. PubMed PMID: 29800465.

39: Sheth KN, Petersen NH, Cheung K, Elm JJ, Hinson HE, Molyneaux BJ, Beslow LA, Sze GK, Simard JM, Kimberly WT. Long-Term Outcomes in Patients Aged ≤70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction: An Exploratory Analysis. Stroke. 2018 Jun;49(6):1457-1463. doi: 10.1161/STROKEAHA.117.020365. Epub 2018 May 22. PubMed PMID: 29789393; PubMed Central PMCID: PMC6192530.

40: Varma AK. Management of brain-stem hemangioblastomas: A bird's-eye view. Neurol India. 2018 May-Jun;66(3):678. doi: 10.4103/0028-3886.232321. PubMed PMID: 29766925.

41: James RF, Khattar NK, Aljuboori ZS, Page PS, Shao EY, Carter LM, Meyer KS, Daniels MW, Craycroft J, Gaughen JR Jr, Chaudry MI, Rai SN, Everhart DE, Simard JM. Continuous infusion of low-dose unfractionated heparin after aneurysmal subarachnoid hemorrhage: a preliminary study of cognitive outcomes. J Neurosurg. 2018 May 11:1-8. doi: 10.3171/2017.11.JNS17894. [Epub ahead of print] PubMed PMID: 29749915.

42: Capper D, Engel NW, Stichel D, Lechner M, Glöss S, Schmid S, Koelsche C, Schrimpf D, Niesen J, Wefers AK, Jones DTW, Sill M, Weigert O, Ligon KL, Olar A, Koch A, Forster M, Moran S, Tirado OM, Sáinz-Jaspeado M, Mora J, Esteller M, Alonso J, Del Muro XG, Paulus W, Felsberg J, Reifenberger G, Glatzel M, Frank S, Monoranu CM, Lund VJ, von Deimling A, Pfister S, Buslei R, Ribbat-Idel J, Perner S, Gudziol V, Meinhardt M, Schüller U. DNA methylation-based reclassification of olfactory neuroblastoma. Acta Neuropathol. 2018 Aug;136(2):255-271. doi: 10.1007/s00401-018-1854-7. Epub 2018 May 5. Erratum in: Acta Neuropathol. 2018 Sep;136(3):505. PubMed PMID: 29730775.

43: Spiotta AM, Arthur AS, Fiorella D, Frei D, Baxter B, Mocco J, Hirsch JA, Turner RD, Turk AS. Is discretion the better part of valor? J Neurointerv Surg. 2018 Aug;10(8):719-720. doi: 10.1136/neurintsurg-2018-013938. Epub 2018 Apr 21. PubMed PMID: 29680820.

44: Williams MM, Wilson TA, Leslie-Mazwi T, Hirsch JA, Kellogg RT, Spiotta AM, De Leacy R, Mocco J, Albuquerque F, Ducruet AF, Arthur A, Srinivasan VM, Kan P, Mokin M, Dumont TM, Reeves A, Singh J, Wolfe SQ, Fargen KM. The burden of neurothrombectomy call: a multicenter prospective study. J Neurointerv Surg. 2018 Apr 20. pii: neurintsurg-2018-013772. doi: 10.1136/neurintsurg-2018-013772. [Epub ahead of print] PubMed PMID: 29678885.

45: Alawieh A, Chatterjee A, Feng W, Porto G, Vargas J, Kellogg R, Turk AS, Turner RD, Imran Chaudry M, Spiotta AM. Thrombectomy for acute ischemic stroke in the elderly: a 'real world' experience. J Neurointerv Surg. 2018 Apr 17. pii: neurintsurg-2018-013787. doi: 10.1136/neurintsurg-2018-013787. [Epub ahead of print] PubMed PMID: 29666180.

46: Olar A, Goodman LD, Wani KM, Boehling NS, Sharma DS, Mody RR, Gumin J, Claus EB, Lang FF, Cloughesy TF, Lai A, Aldape KD, DeMonte F, Sulman EP. A gene expression signature predicts recurrence-free survival in meningioma. Oncotarget. 2018 Feb 15;9(22):16087-16098. doi: 10.18632/oncotarget.24498. eCollection 2018 Mar 23. PubMed PMID: 29662628; PubMed Central PMCID: PMC5882319.

47: Alexandrov AW, Tsivgoulis G, Hill MD, Liebeskind DS, Schellinger P, Ovbiagele B, Arthur AS, Caso V, Nogueira RG, Hemphill JC 3rd, Grotta JC, Hacke W, Alexandrov AV. HeadPoST: Rightly positioned, or flat out wrong? Neurology. 2018 May 8;90(19):885-889. doi: 10.1212/WNL.0000000000005481. Epub 2018 Apr 11. Review. PubMed PMID: 29643083.

48: Goyal N, Tsivgoulis G, Frei D, Turk A, Baxter B, Froehler MT, Mocco J, Ishfaq MF, Malhotra K, Chang JJ, Hoit D, Elijovich L, Loy D, Turner RD, Mascitelli J, Espaillat K, Alexandrov AV, Arthur AS. Comparative Safety and Efficacy of Modified TICI 2b and TICI 3 Reperfusion in Acute Ischemic Strokes Treated With Mechanical Thrombectomy. Neurosurgery. 2018 Mar 30. doi: 10.1093/neuros/nyy097. [Epub ahead of print] PubMed PMID: 29618102.

49: Spiotta AM, Chaudry MI, Turner RD 4th, Turk AS, Derdeyn CP, Mocco J, Tateshima S. An Update on the Adjunctive Neurovascular Support of Wide-Neck Aneurysm Embolization and Reconstruction Trial: 1-Year Safety and Angiographic Results. AJNR Am J Neuroradiol. 2018 May;39(5):848-851. doi: 10.3174/ajnr.A5599. Epub 2018 Mar 29. PubMed PMID: 29599174.

50: Chalela JA, Britell PE. Tactical Neurocritical Care. Neurocrit Care. 2018 Mar 27. doi: 10.1007/s12028-018-0524-x. [Epub ahead of print] PubMed PMID: 29589329.

51: Chhatbar PY, Kautz SA, Takacs I, Rowland NC, Revuelta GJ, George MS, Bikson M, Feng W. Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivo. Brain Stimul. 2018 Jul - Aug;11(4):727-733. doi: 10.1016/j.brs.2018.03.006. Epub 2018 Mar 13. PubMed PMID: 29576498; PubMed Central PMCID: PMC6019625.

52: Gory B, Haussen DC, Piotin M, Steglich-Arnholm H, Holtmannspötter M, Labreuche J, Kyheng M, Taschner C, Eiden S, Nogueira RG, Papanagiotou P, Boutchakova M, Siddiqui AH, Lapergue B, Dorn F, Cognard C, Killer M, Mangiafico S, Ribo M, Psychogios MN, Spiotta AM, Labeyrie MA, Biondi A, Mazighi M, Turjman F; Thrombectomy In TANdem lesions (TITAN) investigators. Impact of intravenous thrombolysis and emergent carotid stenting on reperfusion and clinical outcomes in patients with acute stroke with tandem lesion treated with thrombectomy: a collaborative pooled analysis. Eur J Neurol. 2018 Sep;25(9):1115-1120. doi: 10.1111/ene.13633. Epub 2018 Apr 16. PubMed PMID: 29575634.

53: Reinhardt A, Stichel D, Schrimpf D, Sahm F, Korshunov A, Reuss DE, Koelsche C, Huang K, Wefers AK, Hovestadt V, Sill M, Gramatzki D, Felsberg J, Reifenberger G, Koch A, Thomale UW, Becker A, Hans VH, Prinz M, Staszewski O, Acker T, Dohmen H, Hartmann C, Mueller W, Tuffaha MSA, Paulus W, Heß K, Brokinkel B, Schittenhelm J, Monoranu CM, Kessler AF, Loehr M, Buslei R, Deckert M, Mawrin C, Kohlhof P, Hewer E, Olar A, Rodriguez FJ, Giannini C, NageswaraRao AA, Tabori U, Nunes NM, Weller M, Pohl U, Jaunmuktane Z, Brandner S, Unterberg A, Hänggi D, Platten M, Pfister SM, Wick W, Herold-Mende C, Jones DTW, von Deimling A, Capper D. Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations. Acta Neuropathol. 2018 Aug;136(2):273-291. doi: 10.1007/s00401-018-1837-8. Epub 2018 Mar 21. PubMed PMID: 29564591.

54: Goyal N, Tsivgoulis G, Frei D, Turk A, Baxter B, Froehler MT, Mocco J, Pandhi A, Zand R, Malhotra K, Hoit D, Elijovich L, Loy D, Turner RD, Mascitelli J, Espaillat K, Katsanos AH, Alexandrov AW, Alexandrov AV, Arthur AS. Comparative safety and efficacy of combined IVT and MT with direct MT in large vessel occlusion. Neurology. 2018 Apr 10;90(15):e1274-e1282. doi: 10.1212/WNL.0000000000005299. Epub 2018 Mar 16. PubMed PMID: 29549221.

55: Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D, Koelsche C, Sahm F, Chavez L, Reuss DE, Kratz A, Wefers AK, Huang K, Pajtler KW, Schweizer L, Stichel D, Olar A, Engel NW, Lindenberg K, Harter PN, Braczynski AK, Plate KH, Dohmen H, Garvalov BK, Coras R, Hölsken A, Hewer E, Bewerunge-Hudler M, Schick M, Fischer R, Beschorner R, Schittenhelm J, Staszewski O, Wani K, Varlet P, Pages M, Temming P, Lohmann D, Selt F, Witt H, Milde T, Witt O, Aronica E, Giangaspero F, Rushing E, Scheurlen W, Geisenberger C, Rodriguez FJ, Becker A, Preusser M, Haberler C, Bjerkvig R, Cryan J, Farrell M, Deckert M, Hench J, Frank S, Serrano J, Kannan K, Tsirigos A, Brück W, Hofer S, Brehmer S, Seiz-Rosenhagen M, Hänggi D, Hans V, Rozsnoki S, Hansford JR, Kohlhof P, Kristensen BW, Lechner M, Lopes B, Mawrin C, Ketter R, Kulozik A, Khatib Z, Heppner F, Koch A, Jouvet A, Keohane C, Mühleisen H, Mueller W, Pohl U, Prinz M, Benner A, Zapatka M, Gottardo NG, Driever PH, Kramm CM, Müller HL, Rutkowski S, von Hoff K, Frühwald MC, Gnekow A, Fleischhack G, Tippelt S, Calaminus G, Monoranu CM, Perry A, Jones C, Jacques TS, Radlwimmer B, Gessi M, Pietsch T, Schramm J, Schackert G, Westphal M, Reifenberger G, Wesseling P, Weller M, Collins VP, Blümcke I, Bendszus M, Debus J, Huang A, Jabado N, Northcott PA, Paulus W, Gajjar A, Robinson GW, Taylor MD, Jaunmuktane Z, Ryzhova M, Platten M, Unterberg A, Wick W, Karajannis MA, Mittelbronn M, Acker T, Hartmann C, Aldape K, Schüller U, Buslei R, Lichter P, Kool M, Herold-Mende C, Ellison DW, Hasselblatt M, Snuderl M, Brandner S, Korshunov A, von Deimling A, Pfister SM. DNA methylation-based classification of central nervous system tumours. Nature. 2018 Mar 22;555(7697):469-474. doi: 10.1038/nature26000. Epub 2018 Mar 14. PubMed PMID: 29539639; PubMed Central PMCID: PMC6093218.

56: Lee JS, Lee SJ, Hong JM, Choi JW, Hong JH, Chang HW, Kim CH, Kim YW, Kang DH, Kim YS, Ovbiagele B, Demchuk AM, Hwang YH, Sohn SI. Temporal Changes in Care Processes and Outcomes for Endovascular Treatment of Acute Ischemic Stroke: Retrospective Registry Data from Three Korean Centers. Neurointervention. 2018 Mar;13(1):2-12. doi: 10.5469/neuroint.2018.13.1.2. Epub 2018 Mar 2. PubMed PMID: 29535893; PubMed Central PMCID: PMC5847886.

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406: Ruppert B, Welsh CT, Hannah J, Giglio P, Rumboldt Z, Johnson I, Fortney J, Jenrette JM, Patel S, Scheithauer BW. Glioneuronal tumor with neuropil-like islands of the spinal cord with diffuse leptomeningeal neuraxis dissemination. J Neurooncol. 2011 Sep;104(2):529-33. doi: 10.1007/s11060-010-0505-1. Epub 2010 Dec 25. PubMed PMID: 21188469.

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413: Goddard JC, Oliver ER, Lambert PR. Prevention of cerebrospinal fluid leak after translabyrinthine resection of vestibular schwannoma. Otol Neurotol. 2010 Apr;31(3):473-7. doi: 10.1097/MAO.0b013e3181cdd8fc. PubMed PMID: 20084041.

414: Willis LM, Freeman L, Bickford PC, Quintero EM, Umphlet CD, Moore AB, Goetzl L, Granholm AC. Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts. Glia. 2010 Apr 15;58(6):679-90. doi: 10.1002/glia.20954. PubMed PMID: 20014277; PubMed Central PMCID: PMC2834232.

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The International League Against Epilepsy (ILAE) Neuropsychiatry commission and United States Institute of Medicine report both identified cognitive and psychological comorbidities as a significant issue for individuals with epilepsy, with rates as high as 60%. However, there is a paucity of evidence-based treatments for many psychological conditions (e.g., learning disorders, cognitive function disorders, Behavioral problems). Because of inherent challenges in the implementation of psychological therapy trials and specific considerations for the population with epilepsy, the focus of a review was to provide guidance and recommendations to conduct psychological trials for individuals with epilepsy. Several key areas will be discussed, including selection of patients, trial design, psychological intervention considerations, outcomes and evaluation of results, publication of trial results, and special issues related to pediatric clinical trials. Rigorously designed psychological therapy trials will set the stage for evidence-based practice in the care of individuals with epilepsy, with the goal of improving seizures, side effects, and HRQOL 1).

The safety and probable benefit of the PulseRider (Pulsar Vascular, Los Gatos, California) for the treatment of broad-necked, bifurcation aneurysms was studied in the context of the prospective, nonrandomized, single arm clinical trial-the Adjunctive Neurovascular Support of Wide-neck aneurysm Embolization and Reconstruction (ANSWER) Trial. : Aneurysms treated with the PulseRider device among sites enrolling in the ANSWER trial were prospectively studied and the results are summarized. Aneurysms arising at either the carotid terminus or basilar apex that were relatively broad necked were considered candidates for inclusion into the ANSWER study. RESULTS: Thirty-four patients were enrolled (29 female and 5 male) with a mean age of 60.9 years (27 basilar apex and 7 carotid terminus). Mean aneurysm height ranged from 2.4 to 15.9 mm with a mean neck size of 5.2 mm (range 2.3-11.6 mm). In all patients, the device was delivered and deployed. Immediate Raymond I or II occlusion was achieved in 82.4% and progressed to 87.9% at 6-month follow-up. A modified Rankin Score of 2 or less was seen in 94% of patients at 6 months. CONCLUSION: The results from the ANSWER trial demonstrate that the PulseRider device is safe and offers probable benefit as for the treatment of bifurcation aneurysms arising at the basilar apex or carotid terminus. As such, it represents a useful addition to the armamentarium of the neuroendovascular specialist 2).


The wellness initiative was implemented in July 2015 and available to all faculty and resident physicians in the Department of Neurological Surgery in collaboration with the Medical University of South Carolina Wellness Center. All participants were provided a Fitbit Surge HR wrist monitor (Fitbit, Boston, Massachusetts) and underwent baseline physical and psychological testing.

Six faculty physicians and 9 residents participated. Overall physical fitness levels varied widely between subjects. Health screening demonstrated abnormalities in 80% of participants (elevated systolic blood pressure in 60%, elevated diastolic in 47%, elevated serum low-density lipoprotein in 53%). Body composition analysis demonstrated body weight higher than ideal in 69% (47% overweight; 13% obese). Recommended average body fat mass reduction was 25.4 pounds. Seventy-nine percent reported below-average quality of life compared with the average healthy adult. All subjects reported wanting more time for personal health.

Baseline health and psychological screenings in the department demonstrated alarmingly prevalent, previously undiagnosed abnormalities on cardiovascular and body weight screenings. Obstacles to leading a healthier lifestyle have been identified and solutions have been incorporated into the program. This quality improvement initiative may serve as a template for other programs seeking to improve physician physical and mental well-being 3).

Modi AC, Wagner J, Smith AW, Kellermann TS, Michaelis R. Implementation of psychological clinical trials in epilepsy: Review and guide. Epilepsy Behav. 2017 Jul 19;74:104-113. doi: 10.1016/j.yebeh.2017.06.016. [Epub ahead of print] Review. PubMed PMID: 28734195.
Spiotta AM, Derdeyn CP, Tateshima S, Mocco J, Crowley RW, Liu KC, Jensen L, Ebersole K, Reeves A, Lopes DK, Hanel RA, Sauvageau E, Duckwiler G, Siddiqui A, Levy E, Puri A, Pride L, Novakovic R, Chaudry MI, Turner RD, Turk AS. Results of the ANSWER Trial Using the PulseRider for the Treatment of Broad-Necked, Bifurcation Aneurysms. Neurosurgery. 2017 Apr 25. doi: 10.1093/neuros/nyx085. [Epub ahead of print] PubMed PMID: 28449126.
Spiotta AM, Fargen KM, Denham SL, Fulton ME, Kellogg R, Young E, Patel S, Turner RD. Incorporation of a Physical Education and Nutrition Program Into Neurosurgery: A Proof of Concept Pilot Program. Neurosurgery. 2016 Oct;79(4):613-9. doi: 10.1227/NEU.0000000000001358. PubMed PMID: 27465847.
charleston.txt · Last modified: 2018/10/29 19:55 by administrador