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Chiari type 1 deformity systematic reviews and meta-analysis

Foramen magnum decompression is widely accepted as the standard treatment for syringomyelia associated with Chiari type 1 malformation (CMI). Despite extensive clinical investigations, relevant surgical details are still matter of debate.

Perrini et al. performed a systematic review and meta-analysis of the literature examining the radiological outcome of syringomyelia in adult patients with CMI after different surgical strategies. PRISMA guidelines were followed. A systematic search of three databases was performed for studies published between 1990 and 2018.

The systematic review included 13 studies with a total of 276 patients with CMI associated with syringomyelia. Overall, the rate of post-operative radiological improvement at last follow-up was 81.1% (95% CI 73.3-88.9%; p < 0.001; I2 = 71.4%). The rate of post-operative syrinx shrinkage did not differ significantly among both groups of decompression with the extra-arachnoidal technique and arachnoid dissection (90%, 95% CI 85.1-94.8%, I2 = 0% vs 79.8%, 95% CI 61.7-98%, I2 = 85.5%). A lower rate of post-operative radiological syrinx shrinkage was observed after decompression with splitting of the outer layer of the dura (55.6% 95% CI 40.5-70.8%, I2 = 0%). CSF-related complications and infections were similar among the different groups. This meta-analysis found that FMD with the extra-arachnoidal technique and arachnoid dissection provides similar results in terms of post-operative shrinkage of syringomyelia. Patients undergoing decompression with splitting of the dura presented the lower rate of syrinx reduction. These data should be considered when choosing the surgical approach in adult patients with CMI associated with syringomyelia 1).

Previous studies have attempted to evaluate the utility of preoperative magnetic resonance imaging (MRI) parameters in predicting outcomes in Chiari I malformation. We performed a systematic review and meta-analysis to determine what preoperative imaging features (if any) predict (1) presence of preoperative symptoms or associated findings, (2) need for surgical decompression, or (3) improvement after surgical decompression.

All publications through June 2018 on PubMed, Embase, and Cochrane Library databases were searched using the keywords “Chiari I malformation” AND “decompression” OR “imaging.” One thousand two hundred ten publications were identified, and 20 were included for our systematic review; nine were included in the meta-analysis.

Tonsil position, clivus gradient, and scoliotic curve of > 20° were all associated with the presence of preoperative syrinx. Degree of scoliotic curve was associated with length of syrinx. Pre-operative findings of central syrinx morphology, shorter syrinx, and scoliotic curve < 20° were associated with post-operative stability/improvement. Post-operative symptomatic improvement was associated with preoperative pB-C2 line ≥ 3 mm, absence of scoliosis, and presence of syrinx. By meta-analysis, there was no significant difference in post-operative improvement between patients with and without syrinx (OR = 0.89; 95% CI 0.58-1.37). Meta-analysis showed no significant difference in post-operative improvement between patients with and without basilar invagination (OR = 1.31; 95% CI 0.72-2.36).

Multiple studies have attempted to identify preoperative imaging parameters to predict post-operative improvement, but no consistently reliable criteria have been defined. This review and meta-analysis highlight the importance of considering each patient's clinical history and physical exam within the context of associated radiographic abnormalities 2).

Perrini P, Anania Y, Cagnazzo F, Benedetto N, Morganti R, Di Carlo DT. Radiological outcome after surgical treatment of syringomyelia-Chiari I complex in adults: a systematic review and meta-analysis. Neurosurg Rev. 2020 Jan 17. doi: 10.1007/s10143-020-01239-w. [Epub ahead of print] Review. PubMed PMID: 31953784.
Atchley TJ, Alford EN, Rocque BG. Systematic review and meta-analysis of imaging characteristics in Chiari I malformation: does anything really matter? Childs Nerv Syst. 2019 Nov 7. doi: 10.1007/s00381-019-04398-4. [Epub ahead of print] PubMed PMID: 31701278.
chiari_type_1_deformity_systematic_reviews_and_meta-analysis.txt · Last modified: 2020/02/05 16:51 by administrador