User Tools

Site Tools


chromosome_19

The molecular hallmark feature of oligodendroglioma is codeletion of the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q) 1).

Complete deletion of both the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q) is pathognomonic for oligodendroglioma 2) 3) It is strongly associated with IDH mutation and is mutually exclusive of ATRX & TP53 mutations.


The following are some of the genes located on chromosome 19:

A1BG: encoding protein Alpha-1-B glycoprotein

ACSBG2: encoding enzyme Long-chain-fatty-acid—CoA ligase

ANKRD24: encoding protein Ankyrin repeat domain-containing protein 24

ARMC6: encoding protein Armadillo repeat-containing protein 6

ATG4D: encoding protein Autophagy related 4D, cysteine peptidase

ATP5SL: encoding protein ATP synthase subunit s-like protein

ATPase ASNA1: encoding enzyme ATPase ASNA1 also known as arsenical pump-driving ATPase and arsenite-stimulated ATPase

  BTBD14B: encoding protein Nucleus accumbens-associated protein 1
  CACTIN: encoding protein Cactin
  CCDC130: encoding protein Coiled-coil domain containing 130
  CCDC151: encoding protein Coiled-coil domain containing 151
  CCDC8: encoding protein Coiled-coil domain containing 8
  CCDC94: encoding protein Coiled-coil domain containing 94 (CCDC94),
  DNASE2: encoding protein Deoxyribonuclease II, lysosomal
  EID2:
  ETV2: encoding protein Ets variant 2
  HCST: encoding protein Hematopoietic cell signal transducer
  HRC: encoding protein Sarcoplasmic reticulum histidine-rich calcium-binding protein
  IFI30: encoding enzyme Gamma-interferon-inducible lysosomal thiol reductase
  IGFL3: encoding protein IGF like family member 3
  KRTDAP: encoding protein Keratinocyte differentiation-associated protein
  LIM2: encoding protein Lens fiber membrane intrinsic protein
  LRG1: encoding protein Leucine-rich alpha-2-glycoprotein 1
  LSM4: encoding protein U6 snRNA-associated Sm-like protein LSm4
  LSR: encoding protein Lipolysis-stimulated lipoprotein receptor
  LYPD5: encoding protein LY6/PLAUR domain containing 5
  MBOAT7: encoding enzyme Lysophospholipid acyltransferase 7
  MOBKL2A: encoding enzyme Mps one binder kinase activator-like 2A
  MZF1-AS1: encoding protein MZF1 antisense RNA 1
  NCLN: encoding protein Nicalin
  NFKBID: encoding protein Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor
  NOSIP: encoding enzyme Nitric oxide synthase-interacting protein
  NWD1: NACHT and WD repeat domain containing 1.
  OLFM2: encoding protein Olfactomedin 2
  OSCAR: encoding protein Osteoclast-associated immunoglobulin-like receptor
  PALM: encoding protein Paralemmin
  PDCD5: encoding protein Programmed cell death protein 5
  PLIN4: encoding protein Perilipin 4
  PEX11G: peroxisomal biogenesis factor 11 gamma
  PLVAP: encoding protein Plasmalemma vesicle-associated protein
  PRR12: encoding protein Proline-rich 12
  KLK3: The Prostate-specific antigen (PSA)
  PRX: Periaxin
  PTOV1: encoding protein Prostate tumor overexpressed gene 1 protein
  SBNO2: encoding protein Strawberry notch homolog 2 (Drosophila)
  SEPW1: encoding protein Selenoprotein W
  SFRS14: encoding protein Putative splicing factor, arginine/serine-rich 14
  SFRS16: encoding protein Splicing factor, arginine/serine-rich 16
  SLC5A5: Solute carrier family 5 (sodium iodide symporter), member 5
  STK11: Serine/threonine kinase 11 (Peutz-Jeghers syndrome)
  TBCB: encoding protein Tubulin-folding cofactor B
  TECR: encoding enzyme Trans-2,3-enoyl-CoA reductase
  THOP1: encoding enzyme Thimet oligopeptidase
  TIMM50: encoding enzyme Mitochondrial import inner membrane translocase subunit TIM50
  TIP39: encoding protein Tuberoinfundibular peptide of 39 residues
  TMED1: encoding protein Transmembrane emp24 domain-containing protein 1
  TMEM160: encoding protein Transmembrane protein 160
  TMEM205: encoding protein Transmembrane Protein 205
  UBXN6: encoding protein UBX domain protein 6
  UCA1: a long non-coding RNA Urothelial cancer associated 1
  UPK1A: encoding protein Uroplakin-1a
  USE1: encoding protein Uncharacterized hematopoietic stem/progenitor cells protein MDS032
  Zfp82 zinc finger protein: encoding protein ZFP82 zinc finger protein
  ZSCAN18: encoding protein Zinc finger and SCAN domain containing 18
  ZNF112: encoding protein Zinc finger protein 112
  ZNF134: encoding protein Zinc finger protein 134
  ZNF160: encoding protein Zinc finger protein 160
  ZNF180: encoding protein Zinc finger protein 180
  ZNF208: encoding protein Zinc finger protein 208
  ZNF224: encoding protein Zinc finger protein 224
  ZNF225: encoding protein Zinc finger protein 225
  ZNF226: encoding protein Zinc finger protein 226
  ZNF229: encoding protein Zinc finger protein 229
  ZNF257: encoding protein Zinc finger protein 257
  ZNF264: encoding protein Zinc finger protein 264
  ZNF266: encoding protein Zinc finger protein 266
  ZNF274: encoding protein Zinc finger protein 274
  ZNF331: encoding protein Zinc finger protein 331
  ZNF347: encoding protein Zinc finger protein 347
  ZNF426: encoding protein Zinc finger protein 426
  ZNF473: encoding protein Zinc finger protein 473
  ZNF506: encoding protein Zinc finger protein 506
  ZNF507: encoding protein Zinc finger protein 507
  ZNF536: encoding protein Zinc finger protein 536
  ZNF541: encoding protein Zinc finger protein 541
  ZNF557: encoding protein Zinc finger protein 557
  ZNF571: encoding protein Zinc finger protein 571
  ZNF576: encoding protein Zinc finger protein 576
  Zinc finger protein 613: encoding protein Zinc finger protein 613
  ZNF649: Transcriptional suppressor
  ZNF71: encoding protein Endothelial zinc finger protein induced by tumor necrosis factor alpha
  ZNF737: encoding protein Zinc finger protein 737
  ZNF749: encoding protein Zinc finger protein 749
  ZNF676: encoding protein Zinc finger protein 676
  ZNF772: encoding protein Zinc finger protein 772
  ZNF784: encoding protein Zinc finger protein 784
  ZNF8: encoding protein Zinc finger protein 8
  ZNF83: encoding protein Zinc finger protein 83
  ZNF878: encoding protein Zinc finger protein 878
  ZNF880: encoding protein Zinc finger protein 880

Short arm

  CACNA1A: Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (Familial hemiplegic migraine Type I). Gene map locus 19p13
  COMP: Cartilage oligomeric matrix protein. Gene map locus 19p13.1
  NOTCH3: Notch homolog 3 (Drosophila): Gene map locus 19p13.1-p13.2
  GCDH: Glutaryl-Coenzyme A dehydrogenase. Gene map locus 19p13.2
  BSG: Basigin (Ok blood group)/Extracellular matrix metalloproteinase inducer/CD147. Gene map locus 19p13.3
  ICAM4: Landsteiner and Weiner glycoprotein. Gene map locus 19p13.3
  NRTN: Neurturin, associated with Hirschsprung's disease: Gene locus map 19p13.3
  HCL1: Hair Colour 1; Brown hair colour; BRHC. Gene map locus 19p13.1-q13.11 OMIM: 113750
  EYCL1: Eye Colour 1; Eye colour, green/blue; GEY. Gene map locus 19p13.1-q13.11 OMIM: 227240
  GTPBP3: GTP binding protein 3 19p13.11
  KLF2: Krüppel-like factor 2, also known as Lung Krüppel-like factor. Gene map locus 19p13.11 OMIM: 602016
  FAM32A: family with sequence similarity 32 member A 19q13.11
  DDX39: DExD-box helicase 39. Gene map locus 19p13.12

Long arm

GAPDHS: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 19q13.12

HAMP: Hepcidin antimicrobial peptide. Gene map locus 19q13.12

BCKDHA: Branched chain keto acid dehydrogenase E1, alpha polypeptide (maple syrup urine disease). Gene map location 19q13.1-q13.2

APOE: Apolipoprotein E, gene associated with Alzheimer's disease. Gene map locus 19q13.2

CIC: Capicua transcriptional repressor. Gene map locus 19q13.2

FCGBP: Fc fragment of IgG binding protein

SARS2: seryl-tRNA synthetase 2, mitochondrial. Gene map locus 19q13.2

ATP1A3: ATPase. Gene map locus 19q13.31

DMWD: DM1 locus, WD repeat containing. Gene map locus 19q13.32

PNMA8A: paraneoplastic Ma antigen family member 8A 19q13.32

DMPK: Dystrophia myotonica-protein kinase. Gene map locus 19q13.32

GLTSCR2: Glioma tumor suppressor candidate region gene 2 protein 19q13.33

A1BG: Plasma glycoprotein, unknown function. Gene map locus 19q13.43

LRC: The Leukocyte Receptor Complex is a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. The LRC also includes the KIR locus. Gene map locus 19q13.4 OMIM: 604812

KPTN: Kaptin (actin binding protein) at the tips of stereocilia. Gene map locus 19q13.4[11]

FUT1: The H locus is located on chromosome 19 at 19q13.3. It contains three exons that span more than 5 kb of genomic DNA, and it encodes a fucosyltransferase that produces the H antigen on RBCs.[12]

FUT2: The Se locus is located on chromosome 19 at 19q13.3. It contains two exons that span about 25 kb of genomic DNA. The Se locus encodes a specific fucosyltransferase that is expressed in the epithelia of secretory tissues, such as salivary glands, the gastrointestinal tract, and the respiratory tract. The enzyme it encodes catalyzes the production of H antigen.[12]

MORT (Mortal Obligate RNA Transcript, lincRNA): Gene map locus 19q13.43

1)
Jenkins RB, Blair H, Ballman KV, Giannini C, Arusell RM, Law M, Flynn H, Passe S, Felten S, Brown PD, Shaw EG, Buckner JC. A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma. Cancer Res. 2006 Oct 15;66(20):9852-61. PubMed PMID: 17047046.
2)
Louis DN, Perry A, Reifenberger G, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a sum- mary. Acta Neuropathol. 2016; 131:803–820
3)
Stupp R, Brada M, van den Bent MJ, et al. High- grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014; 25 Suppl 3:iii93–ii101
chromosome_19.txt · Last modified: 2019/10/16 23:06 by administrador