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chronic_pain_treatment

Chronic pain treatment

Patients with chronic pain and comorbid obesity achieved sustained Health-Related Quality of Life (HRQoL) improvements from Interdisciplinary Multimodal Pain Rehabilitation (IMMPR). This finding suggests that rehabilitation professionals should consider using IMMPR for patients with comorbid obesity even though their improvement may not reach the same level as for non-obese patients 1).


Spinal cord stimulation (SCS) is an established therapy for refractory neuropathic pain. To ascertain the balance between treatment benefits and risks, the French National Authority for Health requested a post-market registry for real-world evaluation of the long-term effectiveness and safety of the therapy.

402 patients undergoing implantation with a Medtronic SCS device as either a primo-implant (n=264) or replacement implant (n=138) were enrolled across 28 representative sites in France. Outcome measures at 2 years included pain intensity, satisfaction with treatment, improvement of pain relief and daily life activity, willingness to undergo the treatment again and use of pain treatments. A patient was considered a responder if, compared to baseline, predominant pain reduction was ≥50%.

At the 2-year follow-up visit, predominant pain intensity for primo-implant patients had decreased from baseline (p<0.001), with responder rates of 55%, 36% and 67% for the lower limbs, back and upper limbs, respectively. Most patients acknowledged an improvement in pain relief (89%) and daily life activity (82%), were satisfied with treatment (91%) and willing to undergo the treatment again (93%). A significant decrease (p<0.01) in the proportion of patients receiving pain treatment was observed for all drug and non-drug treatments. Reported adverse events were in line with literature. Pain intensity at 2 years was comparable for patients in the replacement group, supporting the long-term stability and effectiveness of SCS.

Real world evaluation of the use of spinal cord stimulation under the recommendations of the French Health Authority shows that two years after the first implantation of an SCS device close to 60% of the patients retain a significant pain reduction and 74% show improvement in pain scores [of at least 30%] with significant decreases in drug and non-drug pain treatments 2).


Chronic pain syndromes caused by degenerative and post-infectious changes in the cervical spine continue to pose significant management challenges to neurosurgeons and pain practitioners. The identification of an individualized treatment plan, astute surgical technique, comprehensive and multimodal analgesia and adequate rehabilitation processes do not necessarily result in diminished pain.

Deep brain stimulation (DBS) and motor cortex stimulation (MCS) are established surgical modalities that have been successfully used over the last several decades for treatment of numerous chronic pain disorders.

1)
Dong HJ, Larsson B, Rivano Fischer M, Gerdle B. Maintenance of quality of life improvement for patients with chronic pain and obesity after interdisciplinary multimodal pain rehabilitation - a study using the Swedish Quality Registry for Pain Rehabilitation (SQRP). Eur J Pain. 2019 Jul 25. doi: 10.1002/ejp.1457. [Epub ahead of print] PubMed PMID: 31343806.
2)
Brinzeu A, Cuny E, Fontaine D, Mertens P, Luyet PP, Van den Abeele C, Djian MC; French SCS study group. Spinal cord stimulation for chronic refractory pain: long-term effectiveness and safety data from a multicentre registry. Eur J Pain. 2018 Dec 29. doi: 10.1002/ejp.1355. [Epub ahead of print] PubMed PMID: 30597719.
chronic_pain_treatment.txt · Last modified: 2019/07/27 14:17 by administrador